33024-60-1

Basic information

• Product Name: 4-Aminotetrahydropyran hydrochloride
• Synonyms: 4-AMINOTETRAHYDRO-4H-PYRAN HYDROCHLORIDE;4-AMINOTETRAHYDROPYRAN, HCL;4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE;ATHP-HCL;4-AMINOTETRAHYDROPYRAN HYDROCHLORIDE (TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE);Tetrahydro-2H-pyran-4-amine hydrochloride;4-Aminotetrahydro-2H-pyran hydrochloride;TETRAHYDRO-PYRAN-4-YLAMINE HCL
• CAS NO: 33024-60-1
• Molecular Formula: C₅H₁₁NO*ClH
• Molecular Weight: 137.61
• Product Categories: Amines;blocks;Heterocycles;pharmacetical;Heterocycle-other series
• Mol File: 33024-60-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 230-250°C
• Boiling Point: 151.4 °C at 760 mmHg
• Flash Point: 49.3 °C
• Appearance: /
• Vapor Pressure: 3.68mmHg at 25°C
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 4-Aminotetrahydropyran hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminotetrahydropyran hydrochloride(33024-60-1)
• EPA Substance Registry System: 4-Aminotetrahydropyran hydrochloride(33024-60-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 33024-60-1(Hazardous Substances Data)

Usage

General Description

4-Aminotetrahydropyran hydrochloride is a chemical compound that belongs to the class of amines. It is an organic compound with the molecular formula C5H12ClNO and a molecular weight of 137.60 g/mol. 4-Aminotetrahydropyran hydrochloride is commonly used as a precursor in the synthesis of various pharmaceuticals and organic compounds. It is a white to off-white crystalline powder that is soluble in water and ethanol. 4-Aminotetrahydropyran hydrochloride has a wide range of applications in the pharmaceutical industry, including as a building block for the synthesis of drugs and as a reagent in organic chemistry reactions. Its versatility and broad range of applications make it a valuable compound in various industries.

InChI:InChI=1/C5H11NO.ClH/c6-5-1-3-7-4-2-5;/h5H,1-4,6H2;1H

Upstream product

• 61128-73-2 tetrahydropyran-4-one oxime 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 38041-19-9 4-aminotetrahydropyran 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 675112-44-4 N,N-dibenzyltetrahydro-2H-pyran-4-amine 

Downstream Products

• 1183116-13-3 3-amino-4-[(tetrahydro-2H-pyran-4-yl)amino]benzoic acid 
• 2230820-11-6 7-methyl-2-((7-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino)-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one 

Relevant articles and documents

Cross-Coupling of Alkyl Redox-Active Esters with Benzophenone Imines: Tandem Photoredox and Copper Catalysis

Alkyl amines are an important class of organic compounds in medicinal and materials chemistry. Until now very have been very few methods for the synthesis of alkyl amines by metal-catalyzed cross-coupling of alkyl electrophiles with nitrogen nucleophiles. Described here is an approach to employ tandem photoredox and copper catalysis to enable the cross-coupling of alkyl N-hydroxyphthalimide esters, readily derived from alkyl carboxylic acids, with benzophenone-derived imines. Hydrolysis of the coupling products furnish alkylated primary amines. Primary, secondary, and tertiary alkyl groups can be transferred, and the coupling tolerates a diverse set of functional groups. The method allows rapid functionalization of natural products and drugs, and can be used to expedite syntheses of pharmaceuticals from readily available chemical feedstocks.

PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PDE4 INHIBITORS

The invention provides a compound of formula (I) or a salt thereof: wherein R2 is H, C1-3alkyl, n butyl, C1-2fluoroalkyl, cyclopropyl, cyclobutyl, (cyclopropyl)methyl , CN, or CH2OH; R3 is inter alia optionally substituted C4-7cycloalkyl or an optionally substituted heterocyclic group (aa), (bb) or (cc); Ra is H, methyl or ethyl; Rb is H or methyl; R4 is H, methyl, ethyl, n propyl, C(O) Me, or C(O) C1fluoroalkyl; and R5 is: C(O) (CH2)n Ar, C(O) Het, C(O) C1 6alkyl, C(O) C1fluoroalkyl, C(O) (CH2)2 C(O) NR15bNR15b, C(O) CH2 C(O) NR15bNR15b, C(O) NR15b (CH2)m1 Ar, C(O) NR15b Het, C(O) NR15b C1-6 alkyl, C(O) NR5aR5b, S(O)2 (CH2)m2-Ar, S(O)2 Het, S(O)2-C1-6alkyl, or CH2 Ar; or R4 and R5 taken together are-(CH2)p1-, (CH2)2 X5 (CH2)2 , C(O) (CH2)p2 ,-C(O)-N(R15) (CH2)p3 ; or NR4R5 is of sub-formula (y), (y1), (y2) or (y3). The invention also provides the use of the compounds as inhibitors of phosphodiesterase type IV (PDE4) and/or for the treatment and/or prophylaxis of inflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rheumatoid arthritis, allergic rhinitis, psoriasis or atopic dermatitis.

PROCESS FOR PRODUCTION OF 4-AMINOTETRAHYDROPYRANS AND SALTS THEREOF WITH ACIDS, INTERMEDIATES FOR THE PROCESS, AND PROCESS FOR PRODUCTION THEREOF

The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1) : wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.