331242-61-6

Basic information

• Product Name: N-Boc-PEG6-alcohol
• Synonyms: N-Boc-PEG6-alcohol;Boc-NH-PEG6-OH;t-boc-N-amido-PEG6-alcohol
• CAS NO: 331242-61-6
• Molecular Formula: C₁₇H₃₅NO₈
• Molecular Weight: 381.4617
• Mol File: 331242-61-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 487.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.087±0.06 g/cm3(Predicted)
• Solubility: Soluble in DMSO, DCM, DMF
• PKA: 12.23±0.46(Predicted)
• CAS DataBase Reference: N-Boc-PEG6-alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: N-Boc-PEG6-alcohol(331242-61-6)
• EPA Substance Registry System: N-Boc-PEG6-alcohol(331242-61-6)

Safety Data

• Hazardous Substances Data: 331242-61-6(Hazardous Substances Data)

Usage

Description

N-Boc-PEG6-alcohol is a PEG linker containing a Boc protected amine group and a terminal hydroxyl group. The Boc protecting group can be removed under acidic conditions, and the hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

Used in Chemical Synthesis:
N-Boc-PEG6-alcohol is used as a PROTAC bridge for the synthesis of a series of PROTAC molecules, which are important in the development of targeted protein degradation therapies.
Used in Pharmaceutical Industry:
N-Boc-PEG6-alcohol is used as a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs), enhancing the targeted delivery of therapeutic agents to cancer cells and improving treatment outcomes.
Used in Drug Delivery Systems:
N-Boc-PEG6-alcohol is used as a hydrophilic PEG linker to increase the water solubility of compounds, which can improve the bioavailability and pharmacokinetics of drugs in the pharmaceutical industry.

in vitro

PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellookchemlularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.

Upstream product

• 6338-55-2 2-(2-(2-aminoethoxy)ethoxy)ethan-1-ol 

Downstream Products

• 1426687-08-2 tert-butyl (17-(((4S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)oxy)-3,6,9,12,15-pentaoxaheptadecyl)carbamate 
• 1233234-77-9 37-amino-5, 8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontanoic acid tert-butyl ester 
• 331242-04-7 3-[1-(1-amino-3,6,9,12,15,18-hexaoxanonadecyl)-4-(2,5,8,11,14,17,20-heptaoxaheneicosyl)-phenyl]-5-[3-[2,6-dimethyl-4-phenylphenoxy]-propyl]-isoxazole 
• 391684-36-9 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid 
• 1355027-66-5 [2-(21-amino-3-oxo-7,10,13,16,19-pentaoxa-4-azahenicos-1-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetic acid trifluoroacetate 
• 1355027-79-0 tert-butyl [2-(2,2-dimethyl-4,24-dioxo-3,8,11,14,17,20-hexaoxa-5,23-diazahexacosan-26-yl)-4-{[(4-{[(2,6-dimethylphenyl)carbamoyl]amino}phenyl)acetyl]amino}phenoxy]acetate 
• 911209-07-9 tert-butyl N-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate 
• 189209-27-6 tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy] ethoxy]ethoxy]ethyl]carbamate 
• 1264015-83-9 C₄₆H₈₂ClNO₂₁ 
• 1264015-81-7 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoic acid 
• 1264015-79-3 methyl 4-{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoate 
• 1264015-76-0 2-{2-[2-(2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy)ethoxy]ethoxy}ethyl p-tosylate 
• 1264015-86-2 3'-(4{2-[2-(2-{2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl}-3,5-bis[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]benzoylamino)-2,2'-bipyridine-3-amine 
• 1186579-88-3 C₄₀H₅₆N₄O₁₀ 

Relevant articles and documents

Photoactivable nonsymmetrical bifunctional linkers for protein immobilization on attenuated total reflectance FTIR optical devices

The photosensitive 4-azido-2,3,5,6-tetrafluoro-1-benzoyl core has been connected to maleimide-, chloroacetyloxy-, or succinimidyl carbonate motifs through various spacers to furnish a series of bifunctional linkers. One linker (7a) has been used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR (ATR-FTIR) spectroscopy. Linkers featuring a photosensitive aryl azide motif at one end and a function reactive toward nucleophiles at the other end are described. One linker is used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR spectroscopy. Copyright