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331242-61-6

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331242-61-6 Usage

Description

N-Boc-PEG6-alcohol is a PEG linker containing a Boc protected amine group and a terminal hydroxyl group. The Boc protecting group can be removed under acidic conditions, and the hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound.

Uses

Used in Chemical Synthesis:
N-Boc-PEG6-alcohol is used as a PROTAC bridge for the synthesis of a series of PROTAC molecules, which are important in the development of targeted protein degradation therapies.
Used in Pharmaceutical Industry:
N-Boc-PEG6-alcohol is used as a cleavable ADC bridge for the synthesis of antibody drug conjugates (ADCs), enhancing the targeted delivery of therapeutic agents to cancer cells and improving treatment outcomes.
Used in Drug Delivery Systems:
N-Boc-PEG6-alcohol is used as a hydrophilic PEG linker to increase the water solubility of compounds, which can improve the bioavailability and pharmacokinetics of drugs in the pharmaceutical industry.

in vitro

PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellookchemlularubiquitin-proteasomesystemtoselectivelydegradetargetproteins.ADCsarecomprisedofanantibodytowhichisattachedanADCcytotoxinthroughanADClinker.

Check Digit Verification of cas no

The CAS Registry Mumber 331242-61-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,1,2,4 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 331242-61:
(8*3)+(7*3)+(6*1)+(5*2)+(4*4)+(3*2)+(2*6)+(1*1)=96
96 % 10 = 6
So 331242-61-6 is a valid CAS Registry Number.

331242-61-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl tert-butylcarbamate

1.2 Other means of identification

Product number -
Other names N-(tert-butoxycarbonyl)-17-amino-3,6,9,12,15-pentaoxaheptadecane-1-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:331242-61-6 SDS

331242-61-6Downstream Products

331242-61-6Relevant articles and documents

Photoactivable nonsymmetrical bifunctional linkers for protein immobilization on attenuated total reflectance FTIR optical devices

Hammaecher, Catherine,Joris, Bernard,Goormaghtigh, Erik,Marchand-Brynaert, Jacqueline

, p. 7952 - 7959 (2014/01/06)

The photosensitive 4-azido-2,3,5,6-tetrafluoro-1-benzoyl core has been connected to maleimide-, chloroacetyloxy-, or succinimidyl carbonate motifs through various spacers to furnish a series of bifunctional linkers. One linker (7a) has been used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR (ATR-FTIR) spectroscopy. Linkers featuring a photosensitive aryl azide motif at one end and a function reactive toward nucleophiles at the other end are described. One linker is used for the construction of a biosensor for β-lactam antibiotic detection by attenuated total reflectance FTIR spectroscopy. Copyright

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