34404-30-3

Basic information

• Product Name: Boc-D-Glu-OBzl
• Synonyms: BOC-D-GLU(BZL)-OH;BOC-D-GLU-OBZL;BOC-D-GLU(OBZL)-OH;BOC-D-GLUTAMIC ACID-OBZL;BOC-D-GLUTAMIC ACID(OBZL)-OH;BOC-D-GLUTAMIC ACID GAMMA-BENZYL ESTER;BOC-D-GLUTAMIC ACID 1-BENZYL ESTER;BOC-D-GLUTAMIC ACID-ALPHA-BENZYL ESTER
• CAS NO: 34404-30-3
• Molecular Formula: C₁₇H₂₃NO₆
• Molecular Weight: 337.37
• Product Categories: Glutamic acid [Glu, E];Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 34404-30-3.mol

Chemical Properties

• Melting Point: 96.0 to 100.0 °C
• Boiling Point: 522.6 °C at 760 mmHg
• Flash Point: 269.9 °C
• Appearance: /
• Density: 1.197 g/cm³
• Storage Temp.: 0-6°C
• Solubility: soluble in Methanol
• PKA: 4.48±0.10(Predicted)
• BRN: 4154458
• CAS DataBase Reference: Boc-D-Glu-OBzl(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-D-Glu-OBzl(34404-30-3)
• EPA Substance Registry System: Boc-D-Glu-OBzl(34404-30-3)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 34404-30-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Boc-D-Glu-OBzl is used as a key intermediate for the synthesis of glutamic acid analogs, which are known for their potent inhibitory effects on leukotriene A4 hydrolase. This enzyme plays a crucial role in the regulation of inflammatory responses, and its inhibition can lead to the development of novel therapeutic strategies for treating various inflammatory and autoimmune diseases.
Used in Biochemical Research:
In the field of biochemistry, Boc-D-Glu-OBzl serves as an essential component in the study of enzyme mechanisms, particularly those involving glutamic acid. Its unique structure allows researchers to investigate the interactions between enzymes and their substrates, leading to a better understanding of enzymatic processes and the development of targeted therapies for various diseases.
Used in Drug Design and Development:
Boc-D-Glu-OBzl is also utilized in the design and development of new drugs targeting leukotriene A4 hydrolase and other related enzymes. Its incorporation into drug candidates can enhance their potency, selectivity, and pharmacokinetic properties, ultimately contributing to the development of more effective treatments for various medical conditions.

Upstream product

• 100-39-0 benzyl bromide 
• 34404-28-9 N-[(1,1-dimethylethoxy)carbonyl]-D-glutamic acid 
• 6893-26-1 D-Glutamic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79338-14-0 D-glutamic acid 1-benzyl ester 
• 13303-10-1 tert-Butyl 4-nitrophenyl carbonate 

Downstream Products

• 71822-18-9 Boc-D-Glu(Gly-OCH₂Ph)-OCH₂Ph 
• 120059-65-6 Boc-γ-D-Glu(OBzl)-Tyr-Nle-D-Lys(Z)-Trp-Nle-Asp(OBzl)-Phe-NH2 
• 115295-03-9 Boc-γ-D-Glu(α-OBzl)-Tyr-Nle-D-Lys(Z)-Trp-OCH3 
• 184835-02-7 2-tert-butoxycarbonylamino-4-phenethylcarbamoyl-butyric acid benzyl ester 
• 210963-67-0 (R)-N-tert-butoxycarbonyl-δ-hydroxynorvaline benzyl ester 
• 850742-49-3 (R)-N-tert-butoxycarbonyl-δ-bromo-norvaline benzyl ester 
• 850742-61-9 (R)-δ-(9-guaninyl)norvaline benzyl ester 
• 850742-53-9 (R)-N-tert-butoxycarbonyl-δ-(1-thyminyl)norvaline benzyl ester 
• 850742-55-1 (R)-N-tert-butoxycarbonyl-δ-(9-adeninyl)norvaline benzyl ester 
• 850742-77-7 (R)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline 
• 850742-59-5 (R)-N-tert-butoxycarbonyl-δ-(2-amino-6-chloro-9-purinyl)norvaline benzyl ester 
• 850742-57-3 (R)-N-tert-butoxycarbonyl-δ-(N4-benzyloxycarbonyl-1-cytosinyl)norvaline benzyl ester 
• 592530-93-3 (R)-2-Amino-4-phenethylcarbamoyl-butyric acid benzyl ester 
• 592530-94-4 C₂₉H₃₅N₂O₆P 

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