34662-36-7Relevant articles and documents
The pyrazole derivative or its salt in a pharmaceutical composition containing them
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Paragraph 0081, (2017/01/26)
PROBLEM TO BE SOLVED: To provide a novel compound and a pharmaceutical composition useful for treatment and/or prevention of HIV virus infections.SOLUTION: Provided is a pyrazole derivative represented by the general formula (I) or a salt thereof (in the
Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents
Mizuhara, Tsukasa,Kato, Takayuki,Hirai, Atsushi,Kurihara, Hideki,Shimada, Yasuhiro,Taniguchi, Masahiko,Maeta, Hideki,Togami, Hiroaki,Shimura, Kazuya,Matsuoka, Masao,Okazaki, Shiho,Takeuchi, Tomoki,Ohno, Hiroaki,Oishi, Shinya,Fujii, Nobutaka
, p. 4557 - 4561 (2013/08/23)
The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.
Copper-catalyzed chlorination of functionalized arylboronic acids
Wu, Hong,Hynes Jr., John
supporting information; experimental part, p. 1192 - 1195 (2010/04/27)
"Chemical Equation Presented" A mild, efficient, Cu(I)-catalyzed method for the conversion of arylboronic acids to aryl chlorides Is reported. This method is particularly useful for the conversion of electron-deficient arylboronic acids to aryl chlorides, a transformation that is inefficient In the absence of Cu catalysis.
Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus
Menzella, Hugo G.,Tran, Thomas-Toan,Carney, John R.,Lau-Wee, Janice,Galazzo, Jorge,Reeves, Christopher D.,Carreras, Christopher,Mukadam, Sophie,Eng, Sara,Zhong, Ziyang,Timmermans, Pieter B. M. W. M.,Murli, Sumati,Ashley, Gary W.
supporting information; experimental part, p. 1518 - 1521 (2010/02/28)
Inhibition of the protein chaperone Hsp90 is a promising new approach to cancer therapy. We describe the preparation of potent non-benzoquinone ansamycins. One of these analogues, generated by feeding 3-amino-5-chlorobenzoic acid to a genetically engineer
Macrolactams by engineered biosynthesis
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, (2008/12/07)
Macrolactams are made by feeding aromatic amino acids as replacement starter units to a mutant strain of the geldanamycin-producing microorganism Streptomyces hygroscopicus var. geldanus NRRL 3602, wherein the gene cluster encoding enzymes for the biosynt
QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS
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Page/Page column 35, (2010/11/26)
The present invention relates to the use of quinazoline derivatives of formula (I) wherein A, B, R1, R2, R3 and R4 are defined herein, and pharmaceutically acceptable salts thereof, for the treatment or preventi