3483-82-7

Basic information

• Product Name: Ethyl N-benzoyl-L-tyrosinate
• Synonyms: benzoyltyrosineethylester;n-benzoyl-l-tyrosinethylester;BZ-TYR-OET;BZ-TYROSINE-OET;BZO-TYR-OET;BTEE;BENZOYL-TYR-OET;BENZOYL-L-TYROSINE ETHYL ESTER
• CAS NO: 3483-82-7
• Molecular Formula: C₁₈H₁₉NO₄
• Molecular Weight: 313.35
• EINECS: 222-469-2
• Product Categories: Amino Acids Derivatives;Amino Acids;Tyrosine [Tyr, Y];Amino Acids and Derivatives;Amino Acid Ethyl Esters;Amino Acids (C-Protected);Biochemistry;Fmoc-Amino acid series
• Mol File: 3483-82-7.mol

Chemical Properties

• Melting Point: 118-121 °C(lit.)
• Boiling Point: 453.15°C (rough estimate)
• Flash Point: 290.8 °C
• Appearance: White to slightly yellow/Powder
• Density: 1.2389 (rough estimate)
• Vapor Pressure: 5.02E-13mmHg at 25°C
• Refractive Index: -29 ° (C=1, EtOH)
• Storage Temp.: −20°C
• Solubility: almost transparency in Methanol
• PKA: 9.75±0.15(Predicted)
• BRN: 2223819
• CAS DataBase Reference: Ethyl N-benzoyl-L-tyrosinate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl N-benzoyl-L-tyrosinate(3483-82-7)
• EPA Substance Registry System: Ethyl N-benzoyl-L-tyrosinate(3483-82-7)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 3483-82-7(Hazardous Substances Data)

Usage

Uses

Used in Research and Development:
Ethyl N-benzoyl-L-tyrosinate is used as a synthetic substrate for studying IMER (Intracellular Membrane-bound Esterase) systems. Its role in this application is to provide a controlled and specific compound for researchers to investigate the activity and function of IMER enzymes, which are crucial for understanding various biological processes.
Used in Pharmaceutical Industry:
Ethyl N-benzoyl-L-tyrosinate is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential applications in treating different diseases and conditions.
Used in Chemical Synthesis:
Ethyl N-benzoyl-L-tyrosinate is used as a building block in the chemical synthesis of various organic compounds. Its versatile structure makes it a valuable component in the creation of new molecules with specific properties and functions.
Used in Analytical Chemistry:
Ethyl N-benzoyl-L-tyrosinate is used as a reference compound in analytical chemistry for the calibration and validation of analytical methods and techniques. Its well-defined structure and properties make it an ideal candidate for ensuring the accuracy and reliability of experimental results.

InChI:InChI=1/C18H19NO4/c1-2-23-18(22)16(12-13-8-10-15(20)11-9-13)19-17(21)14-6-4-3-5-7-14/h3-11,16,20H,2,12H2,1H3,(H,19,21)

Upstream product

• 949-67-7 L-tyrosine ethyl ester 
• 65-85-0 benzoic acid 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 56598-65-3 (rac)-N-Benzoyltyrosin-ethylester 
• 98-88-4 benzoyl chloride 
• 2566-23-6 N-benzoyl-L-tyrosine 
• 644-32-6 dibenzoyl disulfide 

Downstream Products

• 131684-50-9 Bz-Tyr-Lys-NH₂ 
• 127132-47-2 N-benzoyl-O'-(pent-4-enyl)-L-tyrosine ethyl ester 
• 95043-84-8 N-benzoyl-L-tyrosine butylamide 
• 7369-86-0 Bz-Tyr-Gly-NH₂ 
• 127132-22-3 N-benzoyl-O'-(2,3-epoxypropyl)-L-tyrosine ethyl ester 
• 93880-32-1 2-nitro-N-benzoyltyrosine ethyl ester 
• 195067-03-9 SKF 45523 
• 127132-45-0 N-benzoyl-O'-(prop-2-enyl)-L-tyrosine ethyl ester 
• 127132-44-9 N-benzoyl-L-tyrosine diammonium salt 
• 2566-23-6 N-benzoyl-L-tyrosine 
• 64-17-5 ethanol 
• 119153-84-3 Bz-Tyr-Tyr-NH₂ 
• 129678-28-0 Bz-Tyr-Thr-NH₂ 
• 119153-83-2 Bz-L-Tyr-L-Phe-NH₂ 

Relevant articles and documents

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages

The construction of amide bonds and peptide linkages is one of the most fundamental transformations in all life processes and organic synthesis. The synthesis of structurally ubiquitous amide motifs is essential in the assembly of numerous important molecules such as peptides, proteins, alkaloids, pharmaceutical agents, polymers, ligands and agrochemicals. A method of SO2F2-mediated direct clickable coupling of carboxylic acids with amines was developed for the synthesis of a broad scope of amides in a simple, mild, highly efficient, robust and practical manner (>110 examples, >90% yields in most cases). The direct click reactions of acids and amines on a gram scale are also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields.

Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure-activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists.

Chromatographic Resolutions of Racemates, XI. Comparison of Optically Active Polyamides and Cellulose Triacetate

On optically active polyacrylic and polymethacrylic amides (1a-e) as well as on microcrystalline cellulose triacetate (2), numerous racemates including drugs are separated at least partially, the amide 4f completely on cellulose triacetate.By repeated chromatography on the polyamide 1a, (+)- and (-)-mandelic acid (4a) and (+)-hexobarbital (9d) also were obtained optically pure.