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Cas Database

351-03-1

351-03-1

351-03-1

Identification

Synonyms:Benzeneethanamine,4-fluoro-N,α-dimethyl-;1-(4-Fluorophenyl)-2-(methylamino)propane;p-Fluoro-N,α-dimethylbenzeneethanamine;DL-4-Fluoromethamphetamine;

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Chemical Properties

  • Boiling Point: 221.26 °C at 760 mmHg

  • Flash Point:87.615 °C

  • Density: 0.991 g/cm3

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Relevant articles and documentsAll total 4 Articles be found

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Matzel, Philipp,Krautschick, Lukas,H?hne, Matthias

, p. 2022 - 2027 (2017/10/07)

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

Synthesis and structure-activity relationships of trisubstituted phenyl urea derivatives as neuropeptide Y5 receptor antagonists

Fotsch,Sonnenberg,Chen,Hale,Karbon,Norman

, p. 2344 - 2356 (2007/10/03)

1-((1R,2R)-2-Hydroxy-1-methyl-2-phenylethyl)-1-methyl-3-(4-phenoxyphenyl)urea (1) was identified as a hit from the screening of the neuropeptide Y5 (NPY5) receptor. This lead was optimized for in vitro potency by changing the stereochemistry, the phenylethyl segment, the urea portion, and the 4-phenoxyphenyl group on the molecule. Over 40 analogues of 1 were prepared to study the structure-activity relationship for this series. The most potent compounds in this class have IC50S less than 0.1 nM at the NPY5 receptor (e.g., 40f, 44a, and 47). To determine the functional activity for this series of compounds, selected analogues were tested in a cellular assay measuring forskolin-induced cyclic AMP accumulation in 293 cells transfected with the human NPY5 receptor. All urea analogues tested in the functional assay acted as antagonists (e.g., 1, 32, 40a, and 44e).

Process route upstream and downstream products

Process route

1-(2-chloropropyl)-4-fluorobenzene
7387-75-9

1-(2-chloropropyl)-4-fluorobenzene

methylamine
74-89-5

methylamine

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
With ethanol; at 160 ℃;
4-fluorophenyl acetone
459-03-0

4-fluorophenyl acetone

methylamine hydrochloride
593-51-1

methylamine hydrochloride

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
4-fluorophenyl acetone; methylamine hydrochloride; With titanium(IV) isopropylate; triethylamine; In ethanol; for 3h;
With sodium tetrahydroborate; In ethanol; for 3h; Further stages.;
fluorobenzene
462-06-6

fluorobenzene

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: FeCl3 / -21 - -16 °C
2: ethanol / 160 °C
With ethanol; iron(III) chloride;
4-fluorophenyl acetone
459-03-0

4-fluorophenyl acetone

methylamine
74-89-5

methylamine

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
With glucose dehydrogenase; D-Glucose; imine reductase from Streptomyces ipomoeae; NADPH; In water; for 20h; pH=9.5; Reagent/catalyst; Catalytic behavior; Enzymatic reaction;
With glucose dehydrogenase; D-glucose; nicotinamide adenine dinucleotide phosphate; In aq. buffer; at 30 ℃; for 24h; pH=9; Reagent/catalyst; enantioselective reaction; Enzymatic reaction;
90 % ee
N-[2-(4-fluoro-phenyl)-1-methyl]-ethyl-N-methyl-N-propynyl-amine

N-[2-(4-fluoro-phenyl)-1-methyl]-ethyl-N-methyl-N-propynyl-amine

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

Conditions
Conditions Yield
aus p-Fluorbenzylmethylketon, N-Methylformamid;
(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

sodium carbonate
497-19-8

sodium carbonate

allyl bromide
106-95-6

allyl bromide

(+/-)-N-methyl-N-(2-propenyl)-[2-(4-fluoro-phenyl)-1-methyl]-ethylamine
103596-42-5,186536-99-2,186537-07-5

(+/-)-N-methyl-N-(2-propenyl)-[2-(4-fluoro-phenyl)-1-methyl]-ethylamine

Conditions
Conditions Yield
In acetone;
(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

(S)-4-fluoro methamphetamine

(S)-4-fluoro methamphetamine

(R)-4-fluoro methamphetamine

(R)-4-fluoro methamphetamine

Conditions
Conditions Yield
With column LiChrospher 100 RP-18e; sulfated β-cyclodextrin; In methanol; water; at 20 ℃; Reagent/catalyst;
With Lux i-Amylose-1 column; In hexane; diethylamine; isopropyl alcohol; at 20 ℃; Resolution of racemate;
(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

p-phenoxyphenylisocyanate
59377-19-4

p-phenoxyphenylisocyanate

1-[2-(4-fluoro-phenyl)-1-methyl-ethyl]-1-methyl-3-(4-phenoxy-phenyl)-urea

1-[2-(4-fluoro-phenyl)-1-methyl-ethyl]-1-methyl-3-(4-phenoxy-phenyl)-urea

Conditions
Conditions Yield
In dichloromethane; at 20 ℃; for 18h;
(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine
351-03-1

(±)-1-(4-fluorophenyl)-N-methylpropan-2-amine

C<sub>10</sub>H<sub>14</sub>FN

C10H14FN

C<sub>10</sub>H<sub>14</sub>FN

C10H14FN

Conditions
Conditions Yield
With β‐cyclodextrin; In aq. phosphate buffer; at 25 ℃; pH=2.5; Reagent/catalyst; Resolution of racemate;

351-03-1 Upstream products

351-03-1 Downstream products

Global suppliers and manufacturers

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
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