36263-51-1

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-1-CYCLOHEXANECARBONITRILE
• Synonyms: 1-(4-METHOXYPHENYL)-1-CYCLOHEXANECARBONITRILE;LABOTEST-BB LT00440901;1-(4-methoxyphenyl)cyclohexanecarbonitrile;1-(4-Methoxyphenyl)cyclohexane-1-carbonitrile;1-(4-Methoxyphenyl)-1-cyclohexanecarbonitrile,95%;Cyclohexanecarbonitrile, 1-(4-methoxyphenyl)-
• CAS NO: 36263-51-1
• Molecular Formula: C₁₄H₁₇NO
• Molecular Weight: 215.29
• EINECS: 252-938-7
• Mol File: 36263-51-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 40-45 °C
• Boiling Point: 176-179 °C (2 mmHg)
• Flash Point: 152.6 °C
• Appearance: colorless to yellow-brown low melting solid
• Density: 1.0778
• Vapor Pressure: 2E-05mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• BRN: 2941304
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-1-CYCLOHEXANECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-1-CYCLOHEXANECARBONITRILE(36263-51-1)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-1-CYCLOHEXANECARBONITRILE(36263-51-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 24/25
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 36263-51-1(Hazardous Substances Data)

Usage

Chemical Properties

colorless to yellow-brown low melting solid

InChI:InChI=1/C14H17NO/c1-16-13-7-5-12(6-8-13)14(11-15)9-3-2-4-10-14/h5-8H,2-4,9-10H2,1H3

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 15057-00-8 1-trimethylsilylcyclohexanecarbonitrile 
• 766-05-2 cyclohexane carbonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 104-47-2 p-methoxybenzylnitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 17138-79-3 1-(4-methoxyphenyl)cyclohexanol 
• 20758-60-5 1-(4-methoxyphenyl)cyclohexene 
• 459-60-9 1-fluoro-4-methoxybenzene 

Downstream Products

• 868849-59-6 1-(4-hydroxy-phenyl)-cyclohexanecarbonitrile 
• 613-36-5 4-cyclohexylanisole 
• 56140-77-3 1-(4-methoxyphenyl)cyclohexane-1-carbaldehyde 
• 36970-20-4 1-aminomethyl-1-(4-methoxyphenyl)cyclohexane 
• 1429442-65-8 (1-(4-methoxyphenyl)cyclohexyl)(phenyl)methanone 
• 1429442-40-9 (S)-2-((S)-1,1-dimethylethylsulfinamido)-N,N-diethyl-2-(1-(4-methoxyphenyl)cyclohexyl)-2-phenylacetamide 
• 1429442-39-6 (S)-N-((1-(4-methoxyphenyl)cyclohexyl)(phenyl)methylene)-2-methylpropane-2-sulfinamide 
• 7469-83-2 1-(4-methoxyphenyl)cyclohexane-1-carboxylic acid 

Relevant articles and documents

N2-(2-METHOXYPHENYL)PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to a N2-(2-methoxyphenyl)pyrimidine derivative, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of cancer comprising the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative, the optical isomer thereof, or the pharmaceutically acceptable salt thereof of the present invention is very effective in suppressing anaplastic lymphoma kinase (ALK) activity and as a result it can improve the effectiveness of treatment on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins such as EML4-ALK and NPM-ALK, so that it can be effectively used as a pharmaceutical composition for preventing or treating cancer.

Pd-catalyzed α-arylation of nitriles and esters and γ-arylation of unsaturated nitriles with TMPZnCl?LiCl

Using TMPZnCl?LiCl as a kinetically highly active base, nitriles and esters undergo a Pd-catalyzed α-arylation under mild conditions. Remarkably, in the case of α,β- or β,γ-unsaturated nitriles, a regioselective γ-arylation or a γ-alkenylation is observed.

Facile preparation of α-aryl nitriles by direct cyanation of alcohols with TMSCN under the catalysis of InX3

(Chemical Equation Presented) A convenient and efficient synthesis of α-aryl nitrites was developed by direct cyanation of alcohols with TMSCN under the catalysis of Lewis acid. Using 5-10 mol % of InBr3 as the catalyst, a variety of benzylic alcohols can be converted to the corresponding nitriles in 5-30 min with yields of 46-99%.