3684-83-1

Basic information

• Product Name: 16α,17-Epoxy-11β-hydroxypregn-4-ene-3,20-dione
• Synonyms: XPOFTPYDSZJRKX-DOKHZPOLSA-N
• CAS NO: 3684-83-1
• Molecular Formula: C₂₁H₂₈O₄
• Molecular Weight: 344.45
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 3684-83-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 16α,17-Epoxy-11β-hydroxypregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 16α,17-Epoxy-11β-hydroxypregn-4-ene-3,20-dione(3684-83-1)
• EPA Substance Registry System: 16α,17-Epoxy-11β-hydroxypregn-4-ene-3,20-dione(3684-83-1)

Safety Data

• Hazardous Substances Data: 3684-83-1(Hazardous Substances Data)

Usage

Uses

16α,17-Epoxy-11β-hydroxypregn-4-ene-3,20-dione is an intermediate in the synthesis of 16-Hydroxycorticosterone 20-Hydroxy-21-Acid (H918430), an oxidized derivative of corticosterone (C695700).

Upstream product

• 21803-97-4 (25R)-3β-acetoxy-spirost-5-en-11-one 
• 530088-78-9 3β-hydroxy-pregna-5,16-diene-11,20-dione 
• 53052-93-0 3β,11α-dihydroxy-5,16-dien-pregnane-20-one 
• 1097-51-4 16α,17α-epoxyprogesterone 
• 19427-37-3 16α,17-epoxy-3β,11α-dihydroxy-pregn-5-en-20-one 
• 69065-06-1 (8S,10R,11S,13S,14S,17R)-17-Ethynyl-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 382-44-5 11β-hydroxyandrostenedione 
• 79884-52-9 9-bromo-11β-hydroxy-androst-4-ene-3,17-dione 
• 142409-93-6 (8S,10R,11S,13S,14S)-17-Ethynyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15-dodecahydro-cyclopenta[a]phenanthren-3-one 
• 38521-84-5 3-acetyloxypregna-5,16-diene-20-one 
• 974-23-2 3β-hydroxy-16α,17α-epoxypregn-5-en-20-one 
• 979-02-2 16-dehydropregnenolone acetate 

Downstream Products

• 641-78-1 3α,17-dihydroxy-5β-pregnane-11,20-dione 
• 10455-93-3 17-hydroxy-5β-pregnane-3,11,20-trione 
• 50-04-4 Cortisone acetate 
• 1250-97-1 11α,17α-dihydroxyprogesterone-21-acetate 
• 2503-07-3 9-bromo-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione 
• 25394-47-2 9α-Chlor-11β-hydroxy-16α,17α-isopropylidendioxy-3,20-dioxo-pregnadien-(1,4) 
• 2135-14-0 9-fluoro-11β-hydroxy-16α,17-isopropylidenedioxy-pregna-1,4-diene-3,20-dione 
• 124113-78-6 11α-hydroxy-16α,17-isopropylidenedioxy-pregn-4-ene-3,20-dione 
• 94088-90-1 16α,17α-epoxypregna-4,9(11)-dien-3,20-dione 
• 3834-28-4 9-fluoro-11β,16α,17α-trihydroxy-17β-methyl-D-homo-androsta-1,4-diene-3,17a-dione 
• 595-52-8 9-fluoro-11β,16α,17-trihydroxy-pregna-1,4-diene-3,20-dione 
• 3684-84-2 16α,17-epoxypregn-4-ene-3,11,20-trione 
• 114327-30-9 16α,17-epoxy-11α-methanesulfonyloxy-pregn-4-ene-3,20-dione 

Relevant articles and documents

Preparation method of betamethasone intermediate

The invention relates to a preparation method of a steroid drug intermediate, and concretely relates to a preparation method of a betamethasone intermediate which is 16beta-methyl-17alpha-hydroxypregna-4,9-diene-3,20-dione. The method comprises the following steps: carrying out a cyanidation reaction on 9alpha-hydroxy-4-ene-pregna-3,17-dione, carrying out a ketal protection reaction, carrying out a double elimination reaction, carrying out an epoxy reaction, and carrying out a Grignard addition hydrolysis reaction to prepare the target product. The method is a brand preparation technology for producing the betamethasone intermediate, and has the characteristics of cheap and easily available initial raw material, simple operations of all above reactions, high yield, suitableness for industrial massive production, and realization of the yield and the quality reaching satisfactory levels.