3751-82-4

Basic information

• Product Name: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER
• Synonyms: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER;4-ketopyrrolidine-1,3-dicarboxylic acid diethyl ester;diethyl 4-oxopyrrolidine-1,3-dicarboxylate;4-Oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-eth
• CAS NO: 3751-82-4
• Molecular Formula: C₁₀H₁₅NO₅
• Molecular Weight: 229.2298
• Mol File: 3751-82-4.mol

Chemical Properties

• Melting Point: 59-62 °C
• Boiling Point: 333°Cat760mmHg
• Flash Point: 155.2°C
• Appearance: /
• Density: 1.242g/cm³
• Vapor Pressure: 0.00014mmHg at 25°C
• Refractive Index: 1.489
• PKA: 11.19±0.20(Predicted)
• CAS DataBase Reference: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(3751-82-4)
• EPA Substance Registry System: 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER(3751-82-4)

Safety Data

• Hazardous Substances Data: 3751-82-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER is used as a building block for the synthesis of drugs, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER is utilized as a precursor in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Organic Synthesis:
4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER is employed as a reagent in organic synthesis, facilitating the creation of a diverse range of organic compounds for various applications.
Used as a Catalyst in Chemical Reactions:
4-OXO-PYRROLIDINE-1,3-DICARBOXYLIC ACID DIETHYL ESTER also serves as a catalyst in various chemical reactions, enhancing the efficiency and selectivity of these processes in the field of organic chemistry.

InChI:InChI=1/C10H15NO5/c1-3-15-9(13)7-5-11(6-8(7)12)10(14)16-4-2/h7H,3-6H2,1-2H3

Upstream product

• 13756-47-3 N-(ethoxycarbonyl)-α-amino methyl carboxylic ester 
• 140-88-5 ethyl acrylate 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 
• 999-30-4 ethyl ethoxycarbonylglycinate 
• 14891-08-8 N-ethoxycarbonyl-N-ethoxycarbonylmethyl-β-alanine ethyl ester 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 26862-71-5 ethyl 2,3-dihydro-1H-pyrrolo[3,4-b]quinolin-2-carboxylate 
• 73193-55-2 N-carbethoxy-2-methyl-3-pyrrolidinone 
• 130482-78-9 2-Benzyl-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 130482-83-6 2-(Hydroxy-phenyl-methyl)-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 130482-80-3 2-(3-Benzyloxy-propyl)-3-oxo-pyrrolidine-1-carboxylic acid ethyl ester 
• 1046860-33-6 2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid isopropylamide 
• 1046860-32-5 2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid cyanomethylamide 
• 1046861-00-0 2-amino-4-[2,4-dichloro-6-(2-pyrazol-1-ylethoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid ethylamide 
• 1303415-64-6 2-amino-4-[2,4-dichloro-6-(4,4,4-trifluorobutoxy)phenyl]-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid ethylamide 
• 1207961-60-1 4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine 
• 1207961-51-0 4-{2,4-dichloro-6-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-phenyl}-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine 
• 1047405-14-0 4-[2,4-dichloro-6-(2-(pyrazol-1-yl)ethoxy)phenyl]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamine 
• 1207961-61-2 2-amino-4-{4-chloro-2-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-6-methyl-phenyl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester 
• 1207961-52-1 2-amino-4-{2,4-dichloro-6-[2-(4-fluoro-pyrazol-1-yl)-ethoxy]-phenyl}-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester 

Relevant articles and documents

Method for preparing 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate

The invention provides a method for preparing 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate (I). The method comprises the steps: subjecting glycinate or an acceptable salt thereof (VIII), which serves as a raw material, to a reaction with chloroformate (VII), so as to produce an intermediate ethoxycarbonyl glycinate (VI); subjecting the intermediate (VI) to cyclization with acrylate (V) under alkaline conditions, so as to obtain a pyrrolidone intermediate (IV); and subjecting the intermediate (IV) to a reaction with 1,3-halochloropropane (III) so as to obtain an intermediate (II), and then,carrying out decarboxylation under acidic conditions, thereby obtaining the 3-(3-chloropropyl)-4-oxopyrrolidin-1-carboxylate (I). Compared with old processes, the method has the advantages that processing steps are shortened, processing operations are simplified, and the emission of waste gases, waste water and waste residues and the cost are greatly reduced, thereby being beneficial to industrialized enlarged production.

Method for preparing 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate

The invention provides a novel method for preparing 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate, aiming at solving the technical problems of a traditional 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate synthesis method in the prior art that a flow is complicated, the environmental hazards are great, the safety is low and the yield is low. The technology takes glycine ethyl ester and ethyl acrylate as starting raw materials, and steps of taking benzylamine as a raw material and carrying out debenzylation in a subsequent process are reduced; a process for preparing the 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate is greatly simplified; an existing technology needs 6-step reaction, and the technology only needs 5-step reaction, so that the operation is simplified and a production period is shortened; the method is applicable to large-scale industrial production. The technology does not take the benzylamine as the starting raw material, and the generation ofa cancer-causing high-hazard substance, i.e., benzyl chloride, is directly stopped from the source; harms to an ecological environment and body health of people are effectively avoided; a reaction process is safe and accords with environmental protection requirements of China better; the total yield is greatly improved and the yield is greater than or equal to 50 percent.

2-AMINO PYRIMIDINE COMPOUNDS AS POTENT HSP-90 INHIBITORS

The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

A convergent total synthesis of mappicine ketone: A leading antiviral compound

An efficient total synthesis of the naturally occuring mappicine ketone 1 and mappicine 2 are described. The approach is based on the assembly of tricyclic amine 5 with pseudo acid chloride 20. A Friedlander condensation is utilized for the construction o