14891-08-8

Basic information

• Product Name: N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER
• Synonyms: N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER;N-(Ethoxycarbonyl)-N-(2-ethoxy-2-oxoethyl)-alanine ethyl ester;N-(Ethoxycarbonyl)-N-(ethoxycarbonylethyl)glycine ethyl ester;N,N-bis[2-(1,3-dioxolan-2-yl)ethyl];ETHYL N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYLMETHYL)-3-AMINOPROPIONATE;ETHYL 3-((2-ETHOXY-2-OXOETHYL)(ETHOXYCARBONYL)AMINO)PROPANOATE
• CAS NO: 14891-08-8
• Molecular Formula: C12H21NO6
• Molecular Weight: 275.3
• Mol File: 14891-08-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER(14891-08-8)
• EPA Substance Registry System: N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER(14891-08-8)

Safety Data

• Hazardous Substances Data: 14891-08-8(Hazardous Substances Data)

Upstream product

• 140-88-5 ethyl acrylate 
• 4143-07-1 ethyl 3-<(ethoxycarbonyl)amino>propionate 
• 541-41-3 chloroformic acid ethyl ester 
• 3783-61-7 diethyl 2-azabutane-1,4-dicarboxylate 

Downstream Products

• 1438-38-6 ethyl 1-ethoxycarbonyl-3-oxo-pyrrolidine-2-carboxylate 
• 3751-82-4 ethyl 1-ethoxycarbonyl-4-oxopyrrolidine-3-carboxylate 
• 83455-93-0 (+/-)-3β-(benzyloxy)-1-(ethoxycarbonyl)-2β-(prop-1-en-3-yl)pyrrolidine 

Relevant articles and documents

Method for preparing 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate

The invention provides a novel method for preparing 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate, aiming at solving the technical problems of a traditional 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate synthesis method in the prior art that a flow is complicated, the environmental hazards are great, the safety is low and the yield is low. The technology takes glycine ethyl ester and ethyl acrylate as starting raw materials, and steps of taking benzylamine as a raw material and carrying out debenzylation in a subsequent process are reduced; a process for preparing the 3-(3-chloropropyl)-4-oxopyrrolidine-1-ethyl carboxylate is greatly simplified; an existing technology needs 6-step reaction, and the technology only needs 5-step reaction, so that the operation is simplified and a production period is shortened; the method is applicable to large-scale industrial production. The technology does not take the benzylamine as the starting raw material, and the generation ofa cancer-causing high-hazard substance, i.e., benzyl chloride, is directly stopped from the source; harms to an ecological environment and body health of people are effectively avoided; a reaction process is safe and accords with environmental protection requirements of China better; the total yield is greatly improved and the yield is greater than or equal to 50 percent.

2-AMIN0-5, 7-DIHYDR0-6H- PYRROLO [3, 4-D] PYRIMIDINE DERIVATIVES AS HSP-90 INHIBITORS FOR TREATING CANCER

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

A NOVEL AND STEREOSELECTIVE SYNTHESIS OF CIS-1-8-H-HYDROXYPYRROLIZIDINE

The title compound was synthesized through a regioselective introduction of allyl group at the C2 position of the 3-oxopyrrolidine derivative (2) by sigmatropic rearrangement and an amino cyclization via the episulfonium intermediate (8)