38584-58-6

Basic information

• Product Name: 3-[(2-NITROPHENYL)AMINO]PROPANOIC ACID
• Synonyms: 3-[(2-NITROPHENYL)AMINO]PROPANOIC ACID
• CAS NO: 38584-58-6
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 0
• Mol File: 38584-58-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[(2-NITROPHENYL)AMINO]PROPANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(2-NITROPHENYL)AMINO]PROPANOIC ACID(38584-58-6)
• EPA Substance Registry System: 3-[(2-NITROPHENYL)AMINO]PROPANOIC ACID(38584-58-6)

Safety Data

• Hazardous Substances Data: 38584-58-6(Hazardous Substances Data)

Upstream product

• 57-57-8 β-Propiolactone 
• 88-74-4 2-nitro-aniline 
• 924-73-2 3-amino-propionic acid ethyl ester 
• 88-73-3 2-Chloronitrobenzene 
• 590-92-1 3-Bromopropionic acid 
• 623-33-6 glycine ethyl ester hydrochloride 
• 1493-27-2 ortho-nitrofluorobenzene 
• 33141-24-1 o-nitrobenzene 

Downstream Products

• 155279-23-5 2-(4-hydroxycarbonyl-phenyl)-4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-one 
• 155279-26-8 2-(4-methoxycarbonyl-phenyl)-4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-one 
• 634198-82-6 2-(4-cyclopropylaminocarbonyl-phenyl)-4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-one 
• 945026-32-4 N-benzyl-N-methyl-3-(2-nitro-phenylamino)-propionamide 
• 75655-44-6 3-(1-benzimidazolonyl)propanoic acid 

Relevant articles and documents

A novel 8-nitro quinoline-thiosemicarbazone analogues induces G1/S & G2/M phase cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway

A series of novel 8-nitro quinoline-based thiosemicarbazone analogues were synthesized and characterized by various spectroscopic and single crystal X-ray analyses. The potent antitumor effects of synthesized compounds towards the cancer cells were evaluated by MTT assay. Amongst, the compound 3a exhibited the highest inhibitory activity and the compounds 3f and 3b were also showed significant activity. The molecular mechanistic studies of cell death have demonstrated that the treated potent compound 3a induced G1/S & G2/M phase cell cycle arrest and induced apoptosis via mitochondrial dysfunction and increased the production of cytotoxic ROS levels. The RT-PCR gene expression analysis revealed that the cell death induced by activation of caspase-3 dependent intrinsic apoptotic signaling pathway. Further, the molecular binding affinity of compounds with estrogen receptor alpha was calculated by molecular docking studies. Thus, novel 8-nitro quinoline-thiosemicarbazone analogues provide a unique tool for breast cancer therapeutic tactics.

4,5-DIHYDRO-IMIDAZO[4,5,1-II]QUINOLIN-6-ONES AS PARP INHIBITORS

Compounds of the formula 1, in which R1 and R2 have the meanings indicated in the description, are novel active PARP inhibitors.

NOVEL 4,5-DIHYDRO-IMIDAZO[4,5,1-IJ]QUINOLIN-6-ONES

Compounds of a certain formula 1, in which A, R1 and R2 have the meanings indicated in the description, are novel active PARP inhibitors.