40584-57-4

Basic information

• Product Name: 1-(1-benzothiophen-2-yl)piperidine
• CAS NO: 40584-57-4
• Molecular Formula: C₁₃H₁₅NS
• Molecular Weight: 217.3299
• Mol File: 40584-57-4.mol

Chemical Properties

• Boiling Point: 363.3°C at 760 mmHg
• Flash Point: 173.5°C
• Density: 1.172g/cm³
• Vapor Pressure: 1.82E-05mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: 1-(1-benzothiophen-2-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-benzothiophen-2-yl)piperidine(40584-57-4)
• EPA Substance Registry System: 1-(1-benzothiophen-2-yl)piperidine(40584-57-4)

Safety Data

• Hazardous Substances Data: 40584-57-4(Hazardous Substances Data)

Usage

Chemical structure

A piperidine derivative with a benzothiophene ring attached to the piperidine nitrogen

Pharmacological properties

Potential serotonin reuptake inhibitor and antipsychotic agent

Research focus

Treatment of mood disorders and schizophrenia

Status

Relatively new and emerging compound

Further studies needed

To fully understand its properties and potential applications in medicine and pharmaceuticals

Upstream product

• 110-89-4 piperidine 
• 5394-13-8 2-bromo-1-benzothiophene 
• 7342-82-7 3-Bromothianaphthene 
• 2142-69-0 2-bromophenyl methyl ketone 
• 5542-49-4 piperidin-1-yl benzoate 
• 95-15-8 Benzo[b]thiophene 

Downstream Products

• 243845-90-1 (4-bromo-phenyl)-(2-piperidin-1-yl-benzo[b]thiophen-3-yl)-methanone 
• 63676-08-4 2-(4-methoxyphenyl)benzo[b]thiophen-3-yl 4-[2-(1-piperidyl)ethoxy]phenyl ketone 
• 243845-93-4 (4-bromo-phenyl)-[2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-methanone 

Relevant articles and documents

Copper- and Cobalt-Catalyzed Syntheses of Thiophene-Based Tertiary Amines

Thienylzinc halides and related compounds prepared by deprotonation followed by transmetalation were used in copper-catalyzed amination using N-benzoyloxy secondary amines. By extending the reaction to 1,5-naphthyridine, it was showed that the competitive dimer formation observed in the case of thiophenes was linked with the low stability of some thienylamines rather than homocoupling. Interestingly, thienylzinc halides and related compounds prepared by transmetalation of thienylmagnesium halides, either prepared from their bromo-precursors or generated by deprotometalation, were satisfactorily employed in cobalt-catalyzed aminations. Finally, aminothiophenes were involved in copper-catalyzed mono- and di-N-arylations, affording differently substituted di- and triphenylamines.

A Convenient Approach to 2-Aminobenzo[b]chalcogenophenes Based on Copper-Catalyzed Transformation of 4-(2-Bromophenyl)-1,2,3-chalcogenodiazoles in the Presence of a Base and Amines

The reactions of 4-(2-bromophenyl)-1,2,3-thia-and -selenadiazoles with amines in the presence of potassium carbonate and copper(I) iodide afforded 2-aminobenzo[b]chalcogenophenes. The corresponding thiaand selenamides, prepared by interaction of 4-(2-brom

New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: Synthesis, resolution, and inhibitory activity

We synthesized, separated into enantiomers, and tested for the HIV-1 reverse transcriptase inhibitory activity a group of analogs of dimethyl-1-(1-piperidynyl)cyclobuta[b][1]benzothiophene-2,2a(7bH)-dicarboxylate (NSC-380292). Absolute configurations of the enantiomers were determined based on absolute X-ray structures and analysis of CD spectra. Within pairs of enantiomers the (R,R)-enantiomer was always much more potent HIV-1 reverse transcriptase inhibitor.

Synergistic methodologies for the synthesis of 3-aroyl-2- arylbenzo[b]thiophene-based selective estrogen receptor modulators. Two concise syntheses of raloxifene

Difunctionalized benzo[b]thiophene intermediates are prepared which allow fully independent elaboration of the 2-aryl position or the tether position of benzo[b]thiophene-based selective estrogen receptor modulators (SERMs). Two concise syntheses of the SERM raloxifene (Evista) are presented.