41104-10-3

Basic information

• Product Name: Ethanone, 1-[4-(acetyloxy)phenyl]-2-bromo-
• CAS NO: 41104-10-3
• Molecular Formula: C10H9BrO3
• Molecular Weight: 257.084
• Mol File: 41104-10-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[4-(acetyloxy)phenyl]-2-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[4-(acetyloxy)phenyl]-2-bromo-(41104-10-3)
• EPA Substance Registry System: Ethanone, 1-[4-(acetyloxy)phenyl]-2-bromo-(41104-10-3)

Safety Data

• Hazardous Substances Data: 41104-10-3(Hazardous Substances Data)

Usage

General Description

"Ethanone, 1-[4-(acetyloxy)phenyl]-2-bromo-" is a chemical compound with the molecular formula C10H9BrO3. It is commonly used in Organic Synthesis as a reagent for the synthesis of various other organic molecules. The 1-[4-(acetyloxy)phenyl]-2-bromo- group plays a crucial role in determining the chemical properties and uses of the compound. It is also known to be a potential precursor in the pharmaceutical industry for the synthesis of various drugs. Additionally, it is important to handle this chemical with caution and follow safety protocols due to its potential hazards and risks associated with its usage.

Upstream product

• 99-93-4 4-Hydroxyacetophenone 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 108-24-7 acetic anhydride 
• 2628-16-2 p-acetoxystyrene 
• 3245-23-6 p-ethylphenyl acetate 
• 13031-43-1 4-acetyloxyacetophenone 

Downstream Products

• 52728-03-7 4-(2-hydroxyacetyl)phenyl acetate 
• 52728-04-8 4-(2-(methylthio)-2-oxoacetyl)phenyl acetate 
• 30686-73-8 4-(4-hydroxyphenyl)-2-methylthiazole 
• 1067425-94-8 acetic acid 4-{2-[4-(4-chloro-phenoxy)-phenylamino]-acetyl}-phenyl ester 
• 1416548-73-6 5-(2,5-dimethylphenoxy)-N-(2-(4-hydroxyphenyl)-2-oxoethyl)-2,2-dimethylpentanoic acid amide 
• 471911-16-7 4-(2-aminothiazol-4-yl)phenyl acetate 
• 52536-80-8 1-(4-acetyloxyphenyl)-2-chloroethanone 

Relevant articles and documents

One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.

One-pot synthesis of α-bromo- and α-azidoketones from olefins by catalytic oxidation with in situ-generated modified IBX as the key reaction

Simple one-pot protocols for the syntheses of α-bromoketones and α-azidoketones starting from olefins have been developed by employing catalytic oxidation of the intermediary bromohydrins with in situ-generated modified IBX as the key reaction. The improved procedure involves initial formation of bromohydrin by the reaction of olefin with NBS in acetonitrile-water mixture (1:1) at rt followed by oxidation with in situ-generated 3,4,5,6-tetramethyl-2-iodoxybenzoic acid (TetMe-IBX), produced in catalytic amounts from 3,4,5,6-tetramethyl-2-iodobenzoic and Oxone. α-Bromoketones are further converted in the same pot to the corresponding α-azidoketones using NaN3/NaHCO3. The one-pot conversions are versatile for a variety of olefins that include cyclic as well as acyclic aliphatic olefins and electron-rich and electron-deficient styrenes. Chemoselective bromohydroxylation of electron-rich double bond and subsequent oxidation to the α-bromoketone is demonstrated for a substrate that contains both electron-rich and deficient double bonds.

Highly Efficient Synthesis of α-Halomethylketones via Ce(SO4)2/Acid Co-Catalyzed Hydration of Alkynes

A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through Ce(SO4)2/acid co-catalyzed hydration of a wide range of haloalkynes. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in good to excellent yields, with broad substrate scope. This protocol is an alternative to conventional α-halogenation of ketones.