3245-23-6

Usage

Uses

Used in Food Industry:
ACETIC ACID 4-ETHYLPHENYL ESTER is used as a flavoring agent for its fruity odor, enhancing the taste and aroma of various food products.
Used in Fragrance Industry:
ACETIC ACID 4-ETHYLPHENYL ESTER is used as a component in the manufacturing of fragrances, contributing to the creation of unique and appealing scents.
Used in Pharmaceutical Industry:
ACETIC ACID 4-ETHYLPHENYL ESTER is used in the development and production of pharmaceuticals, potentially serving as an active ingredient or a component in drug formulations.
Used in Organic Synthesis:
ACETIC ACID 4-ETHYLPHENYL ESTER is used as a solvent in organic synthesis, facilitating chemical reactions and aiding in the synthesis of various organic compounds.

InChI:InChI=1/C10H12O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h4-7H,3H2,1-2H3

Upstream product

• 123-07-9 4-Ethylphenol 
• 108-24-7 acetic anhydride 
• 937-30-4 4-ethylacetophenone 
• 75-36-5 acetyl chloride 
• 201230-82-2 carbon monoxide 
• 1515-95-3 p-ethylanisole 
• 74-88-4 methyl iodide 
• 773-99-9 2-naphthaleneethanol 
• 2628-16-2 p-acetoxystyrene 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 100-41-4 ethylbenzene 
• 17993-90-7 4-EtC₆H₄OTMS 
• 13031-43-1 4-acetyloxyacetophenone 

Downstream Products

• 24539-92-2 3-ethyl-6-hydroxyacetophenone 
• 13031-43-1 4-acetyloxyacetophenone 
• 107368-92-3 (+/-)-cis-trikentrin A 
• 161988-81-4 4-ethyl-2-(1-methyl-but-3-enyl)-phenol 
• 161988-80-3 4-ethyl-2-(1-hydroxy-1-methyl-but-3-enyl)-phenol 
• 161988-82-5 4-ethyl-2-(1-methyl-but-3-enyl)-6-nitro-phenol 
• 161988-88-1 1-ethyl-3-(1-methyl-but-3-enyl)-4-triethylsilyloxy-benzene 
• 161988-83-6 4-ethyl-2-(1-methyl-but-3-enyl)-6-nitro-phenyl-trifluoromethanesulphonate 
• 136062-55-0 2-(2-Benzenesulfinyl-1-hydroxy-1-methyl-allyl)-4-ethyl-phenol 
• 41104-10-3 acetic acid 4-(2-bromoacetyl)phenyl ester 
• 1391854-03-7 (R)-1-phenyl-2,2,2-trichloroethyl (R)-1-(4-acetoxyphenyl)ethylcarbamate 
• 1391854-04-8 C₁₉H₁₈Cl₃NO₄ 

Relevant academic research and scientific papers

An efficient method to prepare aryl acetates by the carbonylation of aryl methyl ethers or phenols

Synthesis of valuable chemicals from lignin based compounds is critical for the application of biomass. Here, we develop a method of preparing aryl acetates by the carbonylation of aryl methyl ethers or phenols under low CO pressure. Good to excellent yields of aryl acetates were obtained using different substrates, and a possible reaction mechanism was proposed by conducting a series of control experiments. This method may provide a potential way for the utilization of lignin.

Copper-catalyzed oxidative benzylic C(sp3)-H amination: Direct synthesis of benzylic carbamates

A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of a Cu(i)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source directly leads to the C-N bond formation at the benzylic position. The mild reaction conditions and the broad substrate scope make this transformation a useful method for the late-stage incorporation of a ubiquitous carbamate fragment onto hydrocarbons. This journal is

Selective hydrodeoxygenation of hydroxyacetophenones to ethyl-substituted phenol derivatives using a FeRu?SILP catalyst

The selective hydrodeoxygenation of hydroxyacetophenone derivatives is achieved opening a versatile pathway for the production of valuable substituted ethylphenols from readily available substrates. Bimetallic iron ruthenium nanoparticles immobilized on an imidazolium-based supported ionic liquid phase (Fe25Ru75?SILP) show high activity and stability for a broad range of substrates without acidic co-catalysts. This journal is

Environmentally responsible, safe, and chemoselective catalytic hydrogenation of olefins: ppm level Pd catalysis in recyclable water at room temperature

Textbook catalytic hydrogenations are typically presented as reactions done in organic solvents and oftentimes under varying pressures of hydrogen using specialized equipment. Catalysts new and old are all used under similar conditions that no longer reflect the times. By definition, such reactions are both environmentally irresponsible and dangerous, especially at industrial scales. We now report on a general method for chemoselective and safe hydrogenation of olefins in water using ppm loadings of palladium from commercially available, inexpensive, and recyclable Pd/C, together with hydrogen gas utilized at 1 atmosphere. A variety of alkenes is amenable to reduction, including terminal, highly substituted internal, and variously conjugated arrays. In most cases, only 500 ppm of heterogeneous Pd/C is sufficient, enabled by micellar catalysis used in recyclable water at room temperature. Comparison with several newly introduced catalysts featuring base metals illustrates the superiority of chemistry in water.

New photocatalytic fixed-point deuteration method for carbon-carbon unsaturated bonds

The invention relates to a new photocatalytic fixed-point deuteration method for carbon-carbon unsaturated bonds. The method is characterized in that an olefin or alkyne compound and a deuterium source undergoes a deuteration reaction under the catalysis of a light source and a photocatalyst to obtain a deuterated product, wherein the deuterium source is deuterated water, deuterated alcohol or deuterated acid, and the reaction temperature is between room temperature and 80 DEG C. The fixed-point deuteration reaction of the olefin or alkyne compound is realized under the photocatalysis action of the photocatalyst with environmentally-friendly and cheap deuterated water or a deuteration reagent as a deuterium source to substitute deuterium gas. Compared with traditional deuteration reactions, the method has a higher selectivity, milder reaction conditions and higher economical suitability, and is suitable for large-scale deuterated chemical substance production.

Monodisperse CuPt alloy nanoparticles assembled on reduced graphene oxide as catalysts in the transfer hydrogenation of various functional organic groups

We present herein a new nanocatalyst, namely binary CuPt alloy nanoparticles (NPs) supported on reduced graphene oxide (CuPt-rGO), as a highly active heterogeneous catalyst for the transfer hydrogenation (TH) protocol that is demonstrated to be applicable over the reduction of various unsaturated organic compounds (olefins, aldehydes/ketones and nitroarenes) in aqueous solutions at room temperature. CuPt alloy NPs were synthesized by the co-reduction of metal (II) acetylacetonates by borane-tert-butylamine (BTB) complex in hot oleylamine (OAm) solution and then assembled on reduced graphene oxide (rGO) via ultrasonic-assisted liquid phase self-assembly method. The structure of yielded CuPt NPs and CuPt-rGO nanocatalyst were characterized by TEM, XRD and ICP-MS. The activity of Cu7Pt3-rGO nanocatalysts were then tested for the THs that were conducted in a commercially available high-pressure tube using water as sole solvent and ammonia borane as a hydrogen donor at room temperature. The presented catalytic TH protocol was successfully applied over nitroarenes, olefines and aldehydes/ketones, and all the tested compounds were converted to corresponding reduction products with the yields reaching up to 99% under ambient conditions. Moreover, the Cu7Pt3-rGO nanocatalyst was also reusable in the TH by providing 99% yield after five consecutive runs in TH of nitrobenzene as an example.

Transition-Metal- and Halogen-Free Oxidation of Benzylic sp 3 C-H Bonds to Carbonyl Groups Using Potassium Persulfate

Aryl carbonyl compounds including acetophenones, benzophenones, imides, and benzoic acids are prepared from benzyl substrates using potassium persulfate as oxidant with catalytic pyridine in acetonitrile under mild conditions. Neither transition metals nor halogens are involved in the reactions.

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters

There is a constant need for new therapies against multidrug-resistant (MDR) cancer. Natural compounds are a promising source of novel anticancer agents. We recently showed that protoflavones display activity in MDR cancer cell lines that overexpress the P-glycoprotein (P-gp) drug efflux pump. In this study, 52 protoflavones, including 22 new derivatives, were synthesized and tested against a panel of drug-sensitive parental cells and their MDR derivatives obtained by transfection with the human ABCB1 or ABCG2 genes, or by adaptation to chemotherapeutics. With the exception of protoapigenone, identified as a weak ABCG2 substrate, all protoflavones bypass resistance conferred by these two transporters. The majority of the compounds were found to exhibit mild to strong (up to 13-fold) selectivity against the MCF-7Dox and KB-V1 cell lines, but not to transfected MDR cells engineered to overexpress the MDR transporters. Our results suggest that protoflavones can overcome MDR cancer by evading P-gp-mediated efflux.

Efficient Water Reduction with sp3-sp3 Diboron(4) Compounds: Application to Hydrogenations, H–D Exchange Reactions, and Carbonyl Reductions

A series of crystalline sp3-sp3 diboron(4) compounds were synthesized and shown to promote the facile reduction of water with dihydrogen formation. The application of these diborons as simple and effective dihydrogen and dideuterium sources was demonstrated by conducting a series of selective reductions of alkynes and alkenes, and hydrogen–deuterium exchange reactions using two-chamber reactors. Finally, as the water reduction reaction generates an intermediate borohydride species, a range of aldehydes and ketones were reduced by using water as the hydride source.

PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS

The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.