30686-73-8

Basic information

• Product Name: 4-(2-METHYL-4-THIAZOLYL)PHENOL*
• Synonyms: 4-[4'-(2'-Methyl)thiazolyl]phenol;4-(4-Hydroxyphenyl)-2-Methylthiazole, 97%;Phenol, 4-(2-Methyl-4-thiazolyl)-;4-(2-Methyl-4-thiazolyl)phenol [for BiocheMical Research];4-(2-Methylthiazol-4-yl)phenol
• CAS NO: 30686-73-8
• Molecular Formula: C₁₀H₉NOS
• Molecular Weight: 191.25
• Mol File: 30686-73-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 151℃ (ethanol )
• Boiling Point: 344.3°C at 760 mmHg
• Flash Point: 162°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 3.34E-05mmHg at 25°C
• Refractive Index: 1.628
• Sensitive: Air Sensitive
• BRN: 1104995
• CAS DataBase Reference: 4-(2-METHYL-4-THIAZOLYL)PHENOL*(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYL-4-THIAZOLYL)PHENOL*(30686-73-8)
• EPA Substance Registry System: 4-(2-METHYL-4-THIAZOLYL)PHENOL*(30686-73-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 30686-73-8(Hazardous Substances Data)

Usage

Uses

Potent peroxidase chemiluminescence enhancer for HRP.

InChI:InChI=1/C10H9NOS/c1-7-11-10(6-13-7)8-2-4-9(12)5-3-8/h2-6,12H,1H3

Upstream product

• 50834-78-1 methyl 4-(2-methyl-1,3-thiazol-4-yl)phenyl ether 
• 41104-10-3 acetic acid 4-(2-bromoacetyl)phenyl ester 
• 62-55-5 thioacetamide 
• 13031-43-1 4-acetyloxyacetophenone 
• 99-93-4 4-Hydroxyacetophenone 
• 2491-38-5 2-bromo-1-(4'-hydroxyphenyl)-1-ethanone 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 

Downstream Products

• 868698-09-3 ethyl (R,S)-2-{[4-(2-methyl-1,3-thiazol-4-yl)phenyl]oxy}-5-phenylpent-4-enoate 

Relevant articles and documents

Synthesis and characterization of novel oxime derivatives

Background: The synthesis of effective drugs are very important for the scientist. The various biological effects of the thiazole, oxime and ether functional groups are well known properties by the drug developers. So we have synthesised new molecules which contains three of them on the same molecules. Methods: The acetophenone derivatives have been used for synthesis new oximes. The synthetic pathway includes mainly four steps. s1. α-Bromination of acetophenone derivatives, s2. Synthesis of thiazole ring using brominated acetophenones, s3. Synthesis of ethers using synthesised thiazole, s4. Synthesis of oximes. Results: The synthesised molecules characterised using IR,1H-NMR, 13C-NMR and elementel analysis methods. Conclusion: The new oximes which include thiazole and ether groups have been synthesised using acetophenone derivatives.

Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H3-receptor antagonists

Histamine H3 receptors are critically involved in the pathophysiology of several disorders of the central nervous system (CNS). Among other families of H3-receptor ligands, the proxifan class has recently been described to contain numerous potent histamine H3-receptor antagonists, e.g. ciproxifan or imoproxifan. In the present study, we report on the design of novel heterocyclic proxifan analogues and their antagonist potencies at histamine H3 receptors. The new compounds were tested for in vitro and in vivo H3-receptor antagonist potencies in different species as well as for H3-receptor selectivity vs. H1 and H2 receptors. In vitro, all compounds investigated proved to be potent H3-receptor antagonists in the rat as well as in the guinea-pig. In addition, they showed good to high oral CNS potency in vivo in mice. Especially, oxadiazole derivatives 24-26 displayed nanomolar antagonist activity in vitro and high potency in vivo (ED50=0.47-0.57 mg/kg). The results show that the additional heteroaromatic moieties might act as bioisosteres of the ketone or oxime moieties of ciproxifan or imoproxifan, respectively, and might cause divergent pharmacokinetic properties. Thus, these novel H3-receptor antagonists are interesting leads for further development. Copyright