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Cas Database

4190-14-1

4190-14-1

Identification

  • Product Name:Benzamide,N-(2-oxo-2-phenylethyl)-

  • CAS Number: 4190-14-1

  • EINECS:

  • Molecular Weight:239.274

  • Molecular Formula: C15H13NO2

  • HS Code:2924299090

  • Mol File:4190-14-1.mol

Synonyms:Benzamide,N-phenacyl- (6CI,7CI,8CI);2-(Benzoylamino)acetophenone;2-Benzoylamino-1-phenylethanone;Muricatisine;N-Phenacylbenzamide;NSC 89758;2-Benzamidoacetophenone;N-(2-Keto-2-phenyl-ethyl)benzamide;

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:BenzamidoAcetophenone
  • Packaging:50mg
  • Price:$ 45
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:N-PHENACYLBENZAMIDE Aldrich
  • Packaging:1g
  • Price:$ 33.4
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:N-(2-Oxo-2-phenylethyl)benzamide 95+%
  • Packaging:25g
  • Price:$ 1144
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:N-(2-Oxo-2-phenylethyl)benzamide 95+%
  • Packaging:5g
  • Price:$ 326
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:N-(2-Oxo-2-phenylethyl)benzamide 95+%
  • Packaging:10g
  • Price:$ 587
  • Delivery:In stock
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  • Manufacture/Brand:AstaTech
  • Product Description:BENZAMIDOACETOPHENONE 97%
  • Packaging:5 / G
  • Price:$ 371
  • Delivery:In stock
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  • Manufacture/Brand:AstaTech
  • Product Description:BENZAMIDOACETOPHENONE 97%
  • Packaging:1 / G
  • Price:$ 106
  • Delivery:In stock
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  • Manufacture/Brand:AstaTech
  • Product Description:BENZAMIDOACETOPHENONE 97%
  • Packaging:25 / G
  • Price:$ 1299
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:BENZAMIDO ACETOPHENONE 95.00%
  • Packaging:50MG
  • Price:$ 1732.5
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:BENZAMIDO ACETOPHENONE 95.00%
  • Packaging:5MG
  • Price:$ 756.25
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Relevant articles and documentsAll total 22 Articles be found

Synthesis method of alpha-acylamino ketone compound

-

Paragraph 0020-0026; 0027-0029, (2020/12/08)

The invention discloses a synthesis method of an alpha-acylamino ketone compound, and belongs to the technical field of organic synthesis. The preparation method comprises the following steps: mixingan alkenyl azide compound 1, a carboxylic acid compound 2 and an organic solvent, and heating to react to obtain the alpha-acylamino ketone compound 3. Compared with the prior art, the method has thefollowing advantages: (1) the synthesis process is simple and efficient, no catalyst is needed in the whole process, and the alpha-acylamino ketone compound can be obtained with high yield by dissolving the alkenyl azide compound and the carboxylic acid compound in the solvent and stirring; (2) raw materials are cheap and easy to obtain, reaction conditions are mild, and operation is simple; (3) the substrate is wide in application range and can be used for modifying drug molecules; and (4) the atom economy is high, and the requirements of green chemistry are met.

Synthesis of α-Amidoketones through the Cascade Reaction of Carboxylic Acids with Vinyl Azides under Catalyst-Free Conditions

Gao, Cai,Zhou, Qianting,Yang, Li,Zhang, Xinying,Fan, Xuesen

, p. 13710 - 13720 (2020/11/13)

An efficient synthesis of α-amidoketone derivatives through the cascade reactions of carboxylic acids with vinyl azides is presented. Compared with literature protocols, notable features of this new method include catalyst-free conditions, broad substrate scope, good tolerance of a wide range of functional groups, and high efficiency. In addition, the synthetic potential of this method as a tool for late-stage modification was convincingly manifested by its application in the structural elaborations of a number of carboxylic acid drug molecules.

Site-Selective Conversion of Azido Groups at Carbonyl α-Positions to Diazo Groups in Diazido and Triazido Compounds

Yokoi, Taiki,Tanimoto, Hiroki,Ueda, Tomomi,Morimoto, Tsumoru,Kakiuchi, Kiyomi

, p. 12103 - 12121 (2018/10/09)

This paper reports on the selective conversion of alkyl azido groups at the carbonyl α-position to diazo compounds. Through β-elimination of dinitrogen, followed by hydrazone formation/decomposition, α-azidocarbonyl moieties were transformed into α-diazo carbonyl groups in one step. As these reaction conditions do not involve aryl or general alkyl azides, site-selective conversions of di- and triazides were achieved. Through this method, the successive site-selective conjugation of the triazido molecule with three different components is demonstrated.

Remote C(sp3)-H Oxygenation of Protonated Aliphatic Amines with Potassium Persulfate

Lee, Melissa,Sanford, Melanie S.

, p. 572 - 575 (2017/02/10)

This letter describes the development of a method for selective remote C(sp3)-H oxygenation of protonated aliphatic amines using aqueous potassium persulfate. Protonation serves to deactivate the proximal C(sp3)-H bonds of the amine substrates and also renders the amines soluble in the aqueous medium. These reactions proceed under relatively mild conditions (within 2 h at 80 °C with amine as limiting reagent) and do not require a transition metal catalyst. This method is applicable to a variety of types of C(sp3)-H bonds, including 3°, 2°, and benzylic C-H sites in primary, secondary, and tertiary amine substrates.

2,5-diphenyl-oxazole preparation method

-

Paragraph 0026; 0027; 0036; 0038, (2019/02/04)

The invention relates to a method for preparing scintillation pure grade 2,5-diphenyl oxazole (DPO or PPO for short). The method comprises the following steps: by taking benzoyl glycine as a raw material, performing multiple steps of reaction such as acylating chlorination, Frieldel-Crafts and ring formation, purifying middle products of each step without being separated, and preparing 2,5-diphenyl oxazole by using a one-pot method. An obtained product can be rectified and purified, the requirements of a scintillator cannot be met but metal oxide heating treatment is needed, and thus a 2,5-diphenyl oxazole product for scintillation fluor can be obtained. As the one-pot method is adopted to prepare 2,5-diphenyl oxazole, the reaction steps are reduced, the operation process is simplified, the production efficiency is improved, a purification method is simple, convenient and effective, and on-scale industrialization production is achieved.

Process route upstream and downstream products

Process route

2-azido-1-phenylethan-1-one
1816-88-2

2-azido-1-phenylethan-1-one

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

benzaldehyde
100-52-7

benzaldehyde

acetophenone
98-86-2

acetophenone

benzil
134-81-6

benzil

Conditions
Conditions Yield
In toluene; for 2h; Further Variations:; title compound concentration; light intensity; Product distribution; UV-irradiation;
2-azido-4'-chloroacetophenone
26086-60-2

2-azido-4'-chloroacetophenone

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

acetophenone
98-86-2

acetophenone

benzoic acid
65-85-0,8013-63-6

benzoic acid

2-nitroacetophenone
614-21-1

2-nitroacetophenone

Conditions
Conditions Yield
With oxygen; In toluene; at -63 ℃; Photolysis;
2-azido-1-phenylethan-1-one
1816-88-2

2-azido-1-phenylethan-1-one

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

N-benzyl-N-(2-oxo-2-phenylethyl)benzamide
35363-31-6

N-benzyl-N-(2-oxo-2-phenylethyl)benzamide

α-(N-Benzylamino)acetophenone
50606-93-4

α-(N-Benzylamino)acetophenone

acetophenone
98-86-2

acetophenone

Conditions
Conditions Yield
In toluene; at 20 ℃; Further byproducts given; UV-irradiation;
73%
15%
2-aminoacetophenone hydrochloride
5468-37-1

2-aminoacetophenone hydrochloride

benzoyl chloride
98-88-4

benzoyl chloride

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; Cooling with ice;
100%
With sodium hydrogencarbonate; In ethyl acetate; Ambient temperature;
90%
With sodium carbonate; for 4h;
84%
With sodium hydrogencarbonate; In dichloromethane; water; at 0 - 20 ℃; for 3h;
73%
With pyridine; sodium hydrogencarbonate; In tetrahydrofuran;
70%
With pyridine;
With sodium acetate; acetic acid;
With potassium hydroxide;
With sodium hydroxide;
With pyridine; for 10h; Ambient temperature;
2-(benzoylamino)-1-phenylethanol
34119-82-9

2-(benzoylamino)-1-phenylethanol

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
With -Bu4N+ (MoO5PICO); In dichloromethane; at 50 ℃; for 7h;
94%
With dipyridinium dichromate; molecular sieve; acetic anhydride; In dichloromethane; at 20 ℃; for 4h;
60%
With sodium hydrogencarbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; at 0 - 25 ℃;
0.22 g
1-azidostyrene
16717-64-9

1-azidostyrene

benzoic acid
65-85-0,8013-63-6

benzoic acid

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
In 1,2-dichloro-ethane; at 110 ℃; for 10h; Sealed tube;
76%
hippuryl chloride
53587-10-3

hippuryl chloride

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
With aluminium trichloride;
With aluminum (III) chloride; at 50 ℃; for 3h; Large scale;
2-Amino-1-phenylethanol
7568-93-6,1936-63-6

2-Amino-1-phenylethanol

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide; 1-hydroxy-1H-benzotriazole hydrate / CH2Cl2 / 25 °C
2: 0.22 g / NaHCO3; 1-hydroxy-1,2-benziodoxol-3(1H)-one-1-oxide / CH2Cl2 / 0 - 25 °C
With sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-hydroxybenzotriazol-hydrate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane;
Multi-step reaction with 2 steps
1: 71 percent / sodium hydroxide / 3 h / 20 °C
2: 60 percent / pyridinium dichromate; molecular sieves; acetic anhydride / CH2Cl2 / 4 h / 20 °C
With sodium hydroxide; dipyridinium dichromate; molecular sieve; acetic anhydride; In dichloromethane;
Multi-step reaction with 2 steps
2: 94 percent / 2)2(C5H4N(O)COO)>-Bu4N+ (MoO5PICO) / CH2Cl2 / 7 h / 50 °C
With -Bu4N+ (MoO5PICO); In dichloromethane;
C<sub>22</sub>H<sub>18</sub>N<sub>2</sub>O<sub>2</sub>
774559-32-9

C22H18N2O2

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
With caesium carbonate; In acetonitrile; at 80 ℃; for 0.25h;
47%
phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

N-(2-oxo-2-phenylethyl)benzamide
4190-14-1

N-(2-oxo-2-phenylethyl)benzamide

Conditions
Conditions Yield
With n-butyllithium; In tetrahydrofuran; formic acid; hexane; at -78 - 20 ℃;
23%

Global suppliers and manufacturers

Global( 13) Suppliers
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  • Amadis Chemical Co., Ltd.
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  • SAGECHEM LIMITED
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  • Country:China (Mainland)
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
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  • Antimex Chemical Limied
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  • Chemlyte Solutions
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  • NovaChemistry
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