14850-88-5

Basic information

• Product Name: (Z)-N'-benzylidenebenzohydrazide
• Synonyms: (Z)-N'-benzylidenebenzohydrazide
• CAS NO: 14850-88-5
• Molecular Weight: 224.262
• Mol File: 14850-88-5.mol
• Article Data: 75

Chemical Properties

• CAS DataBase Reference: (Z)-N'-benzylidenebenzohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-N'-benzylidenebenzohydrazide(14850-88-5)
• EPA Substance Registry System: (Z)-N'-benzylidenebenzohydrazide(14850-88-5)

Safety Data

• Hazardous Substances Data: 14850-88-5(Hazardous Substances Data)

Upstream product

• 538-51-2 benzylidene phenylamine 
• 613-94-5 benzoic acid hydrazide 
• 622-30-0 N-benzyl hydroxylalmine 
• 6830-78-0 3,6-diphenyl-1,2,4,5-tetrazine 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 7732-18-5 water 
• 98-88-4 benzoyl chloride 
• 7664-41-7 ammonia 
• 74-88-4 methyl iodide 
• 1215-52-7 N-benzoyl-N'-benzylhydrazine 
• 555-96-4 Benzylhydrazine 
• 100-52-7 benzaldehyde 
• 106-95-6 allyl bromide 
• 1125-88-8 benzaldehyde dimethyl acetal 

Downstream Products

• 725-12-2 2,5-bis-(phenyl)-1,3,4-oxadiazole 
• 1456-21-9 diphenyl-[1,3,4]thiadiazole 
• 28867-76-7 benzaldehyde benzylidenehydrazone 
• 1215-52-7 N-benzoyl-N'-benzylhydrazine 
• 88246-18-8 C₂₁H₁₈N₂OS₂ 
• 32252-82-7 1-chloro-1,4-diphenyl-2,3-diazabutadiene 
• 100-52-7 benzaldehyde 
• 100-47-0 benzonitrile 
• 92311-69-8 N-(3-Chloro-2-oxo-4-phenyl-azetidin-1-yl)-benzamide 
• 55595-96-5 diethyl <1-(diethoxyphosphinyl)-1-phenylmethyl>phosphoramidate 
• 55-21-0 benzamide 
• 1924-86-3 benzaldehyde N-methyl-N-benzoylhydrazone 
• 100-46-9 benzylamine 
• 85759-87-1 (C₅H₅)TiCl((C₆H₅)CHNNC(O)C₆H₅)2 

Relevant articles and documents

A facile procedure for the one-pot synthesis of unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles

Unsymmetrically 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclization-oxidation reaction of acyl hydrazones. Also, the synthesis of the title compounds was achieved by the condensation of acyl hydrazides and aromatic aldehydes in the presence of ceric ammonium nitrate in dichloromethane.

Photochemistry of arylhydrazides in solution

The photochemical reactions of arylhydrazides ArCONHN=CHR in solution were studied. The main photochemical process was shown to be trans - cis isomerization with a quantum yield of 0.2-0.8 and an activation energy of 21-24 kcal mol-1.

Synthesis, characterization and computational study of N-acylhydrazone derivatives

The N-Acylhydrazone of benzoic acid and their derivatives are important intermediates in organic synthesis and have widespread applications in the medicinal industry. The N-Acylhydrazone was prepared through the condensing the phenyl hydrazide derivatives which prepared from phenylmethyl ester, with benzaldehyde and then identified by physicochemical properties and spectral analysis; FT-IR and 1HNMR. Computation calculations studies by using Semi-empirical-PM3 method through a molecular structure with optimized geometry showed that there is a high correlation between dipole moment, Electron affinity (EA), ionization potential (IP), electronegativity, ClogP and hardness. To Proof, the stability of N-Acylhydrazone derivatives by using Molecular orbital calculations supported a full description of the orbitals and the contributions of individual atoms. Highest occupied molecular orbital/lowest unoccupied molecular orbital energies and structures are demonstrated, calculation atomic charge and molecular electrostatic potential. Through the data obtained from the computational chemistry program, Hyper Chem 8, we were able to demonstrate that the N-acylhydrazone derivatives have a close values and within the limits of stability.

Synthesis and biological evaluation in vitro and in silico of N-propionyl-N′-benzeneacylhydrazone derivatives as cruzain inhibitors of Trypanosoma cruzi

Abstract: An N-acylhydrazone scaffold has been used to develop new drugs with diverse biological activities, including trypanocidal activity against different strains of Trypanosoma cruzi. However, their mechanism of action is not clear, although in T. cr