42753-71-9

Basic information

• Product Name: 2-Amino-5-bromo-6-methylpyridine
• Synonyms: 6-Amino-3-bromo-2-methylpyridine ,98%;2-Methyl-3-bromo-6-aminopyridine;5-Bromo-6-methyl-2-pyridinamine;5-Bromo-6-methylpyridine-2-amine;6-Amino-3-bromo-2-picoline,98%;2-amine-5-bromo-6-methylpyridine;2 - aMino - 5 - broMine - 6 - Methyl pyridine;6-Amino-3-bromo-2-methylpyridine,97%
• CAS NO: 42753-71-9
• Molecular Formula: C₆H₇BrN₂
• Molecular Weight: 187.04
• EINECS: 255-927-5
• Product Categories: Halopyridines;C6Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Amino-pyridine series;Heterocycle-Pyridine series;compounds of pyridine;blocks;Bromides;Pyridines;Pyridine;Amines and Anilines;Heterocycles;Pyridines, Pyrimidines, Purines and Pteredines;Amines;Bromopyridines
• Mol File: 42753-71-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 79-84 °C(lit.)
• Boiling Point: 234.3 °C at 760 mmHg
• Flash Point: 95.5 °C
• Appearance: White to off-white/Fluffy Powder
• Density: 1.5672 (rough estimate)
• Vapor Pressure: 0.0534mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.80±0.37(Predicted)
• Sensitive: Hygroscopic
• BRN: 114140
• CAS DataBase Reference: 2-Amino-5-bromo-6-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-bromo-6-methylpyridine(42753-71-9)
• EPA Substance Registry System: 2-Amino-5-bromo-6-methylpyridine(42753-71-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-26/37/39
• WGK Germany: 3
• TSCA: Yes
• HazardClass: IRRITANT
• Hazardous Substances Data: 42753-71-9(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow Cryst

InChI:InChI=1/C6H7BrN2/c1-4-5(7)2-3-6(8)9-4/h2-3H,1H3,(H2,8,9)/p+1

Upstream product

• 3430-17-9 2-bromo-3-picoline 
• 1824-81-3 2-Amino-6-methylpyridine 

Downstream Products

• 116355-19-2 6-bromo-5-methylimidazo<1,2-a>pyridine 
• 183428-90-2 2-amino-5-cyano-6-methylpyridine 
• 1104066-46-7 3-(5-bromo-6-methylpyridin-2-yl)-2-(2,6-dibromophenyl)thiazolidin-4-one 
• 1029127-96-5 N-(5-bromo-6-methylpyridin-2-yl)-2,2-dimethylbutanamide 
• 1545501-03-8 6-bromo-3,5-dimethyl-2-phenylimidazo[1,2-a]pyridine 
• 137778-18-8 5-bromo-6-methyl-pyridine-2-carbaldehyde 
• 1211589-43-3 3-bromo-6-fluoro-2-picolinic acid 
• 910054-74-9 (5-boronic acid-6-methyl-pyridin-2-yl)-dimethyl-amine 
• 910054-73-8 (5-bromo-6-methyl-pyridin-2-yl)-dimethyl-amine 
• 1220219-97-5 6-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-amine 
• 1171975-58-8 2-amino-5-(4-chloro-3-trifluoromethylphenoxy)-6-methylpyridine 
• 943917-51-9 5-(4-methoxyphenyl)-6-methylpyridin-2-amine 
• 57963-08-3 2-amino-5,6-dimethylpyridine 
• 286369-97-9 N-(5-Bromo-6-methyl-2-pyridyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}urea 

Relevant articles and documents

Directing Group Enables Electrochemical Selectively Meta-Bromination of Pyridines under Mild Conditions

Without the use of catalysts and oxidants, a facile and sustainable electrochemical bromination protocol was developed. By introducing the directing groups, the regioselectivity of pyridine derivatives could be controlled at themeta-position utilizing the inexpensive and safe bromine salts at room temperature. A variety of brominated pyridine derivatives were obtained in 28-95% yields, and the reaction could be readily performed at a gram scale. By combining the installation and removing the directing group, the concept ofmeta-bromination of pyridines could be verified.

multi-links class PI3K inhibitors (by machine translation)

The invention belongs to the field of medical technology, in particular of formula (I) shown in multi-links class of PI3K inhibitors, its stereoisomers or its pharmaceutically acceptable salt thereof, wherein the R 1, R 2, R 3, R 4 or R 5 as defined in the specification; the invention also relates to methods of preparing such compounds, pharmaceutical compositions of these compounds in the preparation and treatment and/or prevention of proliferative diseases of the use of the medicament. (by machine translation)

Preparation method of 2-amino-5-methyl-6-bromopyridine

For overcoming defects in the prior art, the invention provides a preparation method of 2-amino-5-methyl-6-bromopyridine, which belongs to the technical field of synthesis of pharmaceutical intermediates. The method comprises the following steps: adding an organic solvent subjected to water removal into sodamide under the protection of nitrogen, then heating a solution, and after 2-bromo-3-methylpyridine is added, carrying out reflux reaction on the obtained mixture under the condition that the temperature is kept; and after the reaction is completed, cooling the solution, adding ice water, separating out an upper organic solvent, and sequentially carrying out concentration and crystallization on the organic solvent, so that a product is obtained. According to the invention, a product is directly obtained through one-step amination, therefore, the method is safe and simple in process, and suitable for industrial production.