42772-85-0

Basic information

• Product Name: 2-(4-Methylphenyl)sulfonyloxyethanol
• Synonyms: 2-(4-Methylphenyl)sulfonyloxyethanol;2-HYDROXYETHYL 4-METHYLBENZENESULFONATE
• CAS NO: 42772-85-0
• Molecular Formula: C₉H₁₂O₄S
• Molecular Weight: 216.25418
• Mol File: 42772-85-0.mol
• Article Data: 39

Chemical Properties

• Melting Point: 135-136 °C
• Boiling Point: 376.8°C at 760 mmHg
• Flash Point: 181.7°C
• Appearance: /
• Density: 1.288g/cm³
• Vapor Pressure: 2.39E-06mmHg at 25°C
• Refractive Index: 1.54
• PKA: 13.76±0.10(Predicted)
• CAS DataBase Reference: 2-(4-Methylphenyl)sulfonyloxyethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Methylphenyl)sulfonyloxyethanol(42772-85-0)
• EPA Substance Registry System: 2-(4-Methylphenyl)sulfonyloxyethanol(42772-85-0)

Safety Data

• Hazardous Substances Data: 42772-85-0(Hazardous Substances Data)

Usage

General Description

2-(4-methylphenyl)sulfonyloxyethanol is a chemical compound with the molecular formula C9H12O4S. It is a sulfonyloxyethanol derivative and contains a sulfonyloxy group attached to a phenyl group. This chemical is commonly used as a reagent for the synthesis of other organic compounds, and it may have potential applications in pharmaceutical and industrial processes. Additionally, 2-(4-methylphenyl)sulfonyloxyethanol may have properties that make it useful in the field of organic chemistry, and its molecular structure suggests it has potential as a building block for the preparation of various types of compounds. Further research may reveal additional properties and potential uses of this chemical.

InChI:InChI=1/C9H12O4S/c1-8-2-4-9(5-3-8)14(11,12)13-7-6-10/h2-5,10H,6-7H2,1H3

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 104-15-4 toluene-4-sulfonic acid 
• 107-21-1 ethylene glycol 
• 542-59-6 2-hydroxyethyl acetate 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 6123-63-3 4-acetyl-5-methyl-1-phenylpyrazole 
• 96-49-1 [1,3]-dioxolan-2-one 
• 75-21-8 oxirane 
• 7182-86-7 tetrabutylammonium p-toluenesulfonate 

Downstream Products

• 958233-17-5 2-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)ethyl 4-methylbenzenesulfonate 
• 1517-05-1 2-azidoethanol 
• 1245721-44-1 2-{[(4-methylphenyl)sulfonyl](prop-2-yn-1-yl)amino}ethyl 4-methylbenzenesulfonate 
• 115147-99-4 C₂₈H₄₂O₈S₂ 
• 67521-22-6 4-(2-hydroxyethoxy)-styrene 
• 1711-24-6 4-(2-hydroxyethoxy)benzoic acid 
• 25781-99-1 3-(2-hydroxyethoxy)benzoic acid 
• 55211-84-2 2-(2-hydroxyethoxy)benzoic acid 
• 148400-72-0 2-[tert-butyl(dimethyl)silyl]oxyethyl 4-methylbenzenesulfonate 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 1032900-27-8 2-[4-(4-{5-chloro-4-[2-(propane-2-sulfonyl)-phenylamino]-pyrimidin-2-ylamino}-5-isopropoxy-2-methyl-phenyl)-piperidin-1-yl]-ethanol 
• 383-50-6 2-fluoroethyl tosylate 

Relevant articles and documents

Pd/Cu-Catalyzed Vinylation of Terminal Alkynes with (2-Bromoethyl)diphenylsulfonium Triflate

The potential of (2-bromoethyl)diphenylsulfonium triflate to be a powerful vinylation reagent was determined by the Sonogashira cross-coupling reactions with terminal alkynes. The vinylation proceeded smoothly at 25 °C under Pd/Cu catalysis to afford a variety of 1- and 2-unsubstituted 1,3-enynes in moderate to excellent yields. This protocol represents the first application of (2-haloethyl)diphenylsulfonium triflate as a CH═CH2 transfer source in organic synthesis.

Regioselective Sulfonylation/Acylation of Carbohydrates Catalyzed by FeCl3 Combined with Benzoyltrifluoroacetone and Its Mechanism Study

A catalytic amount of FeCl3 combined with benzoyl trifluoroacetone (Hbtfa) (FeCl3/Hbtfa = 1/2) was used to catalyze sulfonylation/acylation of diols and polyols using diisopropylethylamine (DIPEA) or potassium carbonate (K2CO3) as a base. The catalytic system exhibited high catalytic activity, leading to excellent isolated yields of sulfonylation/acylation products with high regioselectivities. Mechanism studies indicated that FeCl3 initially formed [Fe(btfa)3] (btfa = benzoyl trifluoroacetonate) with twice the amount of Hbtfa under basic conditions in the solvent acetonitrile at room temperature. Then, Fe(btfa)3 and two hydroxyl groups of the substrates formed a five- or six-membered ring intermediate in the presence of the base. The subsequent reaction between the cyclic intermediate and a sulfonylation reagent led to the selective sulfonylation of the substrate. All key intermediates were captured in the high-resolution mass spectrometry assay, therefore demonstrating this mechanism for the first time.

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.