42833-66-9

Basic information

• Product Name: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE
• Synonyms: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE;UKRORGSYN-BB BBV-229965
• CAS NO: 42833-66-9
• Molecular Formula: C₁₀H₁₁ClO₄
• Molecular Weight: 230.64
• Mol File: 42833-66-9.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 346.9°C at 760 mmHg
• Flash Point: 148.2°C
• Appearance: /
• Density: 1.227g/cm³
• Vapor Pressure: 5.57E-05mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE(42833-66-9)
• EPA Substance Registry System: 2,4,5-TRIMETHOXY-BENZOYL CHLORIDE(42833-66-9)

Safety Data

• Hazardous Substances Data: 42833-66-9(Hazardous Substances Data)

Usage

Uses

Asaronic Chloride is an intermediate in the synthesis of 2-[(2-Hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxylic Acid (H972788) which is an impurity of Acotiamide (A190260), an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats. Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

InChI:InChI=1/C10H11ClO4/c1-13-7-5-9(15-3)8(14-2)4-6(7)10(11)12/h4-5H,1-3H3

Upstream product

• 490-64-2 asaronic acid 
• 20029-76-9 methyl 2,4,5-trimethoxybenzoate 

Downstream Products

• 50879-52-2 2,4,5-trimethoxy-N-phenylbenzamide 
• 42833-68-1 2,4,6-trimethoxy-2'-hydroxy-4',5'-dimethoxybenzophenone 
• 76013-33-7 4,6-dimethoxy-2-hydroxy-2',4',5'-trimethoxybenzophenone 
• 76006-83-2 2,2',4,4',5',6-hexamethoxybenzophenone 
• 145354-03-6 3,4-dimethoxy-2-hydroxy-2',4',5'-trimethoxybenzophenone 
• 145354-04-7 2,3,4-trimethoxy-2'-hydroxy-4',5'-dimethoxybenzophenone 
• 131168-59-7 2-(2',4',5'-trimethoxybenzoyloxy)-3,4,5,6-tetramethoxyacetophenone 
• 137709-56-9 4,4-tetramethylene-1-(2,4,5-trimethoxyphenyl)-7-trimethylsilyl-6-heptyn-1,3,5-trione 
• 105518-12-5 N,N-diethyl-2,4,5-trimethoxybenzamide 
• 73405-22-8 2,4,5-Trimethoxybenzoyl-ethylacetat 
• 750649-59-3 3-(diphenyl-phosphinoyl)-5,6-dimethoxy-2-methyl-2,3-dihydro-isoindol-1-one 
• 185105-98-0 ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate 
• 52751-82-3 N-(4-bromophenyl)-2,4,5-trimethoxybenzamide 

Relevant articles and documents

Synthesis and in silico and in vitro evaluation of trimethoxy-benzamides designed as anti-prion derivatives

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are neurodegenerative disorders which affect mammals, including the human species, and arise after the conversion of the monomeric cellular prion protein (PrPC) int

Preparation method of acotiamide hydrochloride impurity

The invention discloses a preparation method of an acotiamide hydrochloride impurity, which comprises the following steps: carrying out acylating chlorination on raw material 2, 4, 5-trimethoxybenzoicacid to obtain 2, 4, 5-trimethoxybenzoyl chloride, and

Method for synthesizing acotiamide hydrochloride

The invention discloses a method for synthesizing acotiamide hydrochloride. According to the method, 2,4,5-trimethoxybenzoic acid, thionyl chloride, methylbenzene, dichloromethane, 2-aminothiazole-4-ethyl formate, N-N-dimethyl formamide, pyridine Hydrochl