185105-98-0

Usage

Uses

Used in Pharmaceutical Industry:
Acotiamide INT is used as an impurity in the development of Acotiamide, an acetylcholinesterase inhibitor, for the treatment of gastric motility dysfunction and functional dyspepsia. Its presence in the compound contributes to the overall effectiveness of Acotiamide in improving meal-related symptoms and promoting gastric motility.
Used in Research and Development:
Acotiamide INT is used as a research compound for studying the effects of Acotiamide on gastric motility and functional dyspepsia. This helps in understanding the mechanisms of action and potential applications of Acotiamide in the treatment of gastrointestinal disorders.
Used in Quality Control:
Acotiamide INT is used in the quality control process of Acotiamide production to ensure the purity and efficacy of the final product. By monitoring the levels of this impurity, manufacturers can maintain the desired therapeutic effects and safety profile of Acotiamide.

Upstream product

• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 
• 70-23-5 ethyl Bromopyruvate 
• 5398-36-7 2-aminothiazole-4-carboxylate 
• 490-64-2 asaronic acid 

Downstream Products

• 1809272-85-2 2-[N-(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid 
• 185106-16-5 Acotiamide 
• 185104-11-4 2-[N-(4,5-dimethoxy-2-hydroxybenzoyl)amino]-4-[(2-diisopropyl-aminoethyl)aminocarbonyl]-1,3-thiazole hydrochloride 

Relevant academic research and scientific papers

Preparation method of acotiamide hydrochloride impurity

The invention discloses a preparation method of an acotiamide hydrochloride impurity, which comprises the following steps: carrying out acylating chlorination on raw material 2, 4, 5-trimethoxybenzoicacid to obtain 2, 4, 5-trimethoxybenzoyl chloride, and

Industrial production method of acotiamide hydrochloride

The invention discloses an industrial production method of acotiamide hydrochloride. The industrial production method comprises the following steps that firstly, 2,4,5-trimethoxy benzoic acid serves as an initial raw material, acylating chlorination is ca

IMPROVED METHOD FOR MANUFACTURING ACOTIAMIDE

PROBLEM TO BE SOLVED: To provide a method for manufacturing acotiamide or acotiamide hydrochloride trihydrate capable of avoiding the use of 2,4,5-trimethoxy benzoyl chloride that is an intermediate manufactured by using thionyl chloride. SOLUTION: There is provided a method for manufacturing acotiamide or acotiamide hydrochloride trihydrate comprising the steps of: manufacturing 2-[(2,4,5-trimethoxy benzoyl) amino]-1,3-thiazole-4-ethyl carboxylate from 2,4,5-trimethoxy benzoic acid S- (benzothiazole-2-yl) and 2-amino-1,3-thiazole-4-ethyl carboxylate; manufacturing 2-[(2-hydroxy-4,5-dimethoxy benzoyl) amino]-1,3-thiazole-4-ethyl carboxylate by demethylation; and reacting the resultant product with N,N-diisopropyl ethylenediamine to manufacture acotiamide. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

A hydrochloric acid arab league tests for the amine intermediate and its synthesis process and application

The invention provides an acotiamide hydrochloride intermediate, and a synthesis technique and application thereof, belonging to the technical field of drug synthesis. The synthesis technique comprises the following steps: (1) mixing 2,4,5-trimethoxy benz

Preparation method of acotiamide intermediate

The invention belongs to the field of medicines, and concretely relates to a preparation method of an acotiamide intermediate. The method comprises the following steps: preparing acyl chloride from 2,4,5-trimethoxybenzoic acid, condensing acyl chloride an

A Three-Step Synthesis of Acotiamide for the Treatment of Patients with Functional Dyspepsia

A three-step synthesis of acotiamide is described. The agent is marketed in Japan for treatment of patients with functional dyspepsia. We designed a one-pot method to prepare the key intermediate 5a from 2 via an acyl chloride and amide and then reacted w

Aminothiazole derivative, medicament containing the same, and intermediate for preparation of said compound

The present invention relates to an aminothiazole derivative represented by the following formula (I): STR1 wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydroxy group, a lower alkyl group, a lower