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Cas Database

4432-43-3

4432-43-3

Identification

  • Product Name:4-Morpholinemethanol

  • CAS Number: 4432-43-3

  • EINECS:

  • Molecular Weight:117.148

  • Molecular Formula: C5H11 N O2

  • HS Code:2934999090

  • Mol File:4432-43-3.mol

Synonyms:4-(Hydroxymethyl)morpholine;Morpholinomethanol; N-(Hydroxymethyl)morpholine; NSC 28861

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 7 Articles be found

Process for Productions of Formamides and Acrylamides

-

Paragraph 0022; 0023, (2020/02/27)

This invention relates to performance chemicals field, it discloses a novel and green process for simultaneous productions of formamides as well as mono- and multi-functional acrylamides under very mild conditions and with high efficiency. These substances are widely useful as industrial solvents or raw materials, in particular acrylamides are important olefinically-unsaturated polymerizable monomers in photo-curing materials.

In situ generated amine as a Lewis base catalyst in the reaction of 3,7-dinitro-1,3,5,7-tetraazabicyclo[3.3.1]nonane in nitric acid: Experimental and DFT study

Zhang, Yu,Chi, Guoli,He, Ying,Xu, Zishuai,Zhang, Luyao,Luo, Jun,Zhou, Baojing

supporting information, (2019/04/08)

The problem how ammonium nitrate affects the nitrolysis of 3,7-dinitro-1,3,5,7-tetraazabicyclo[3.3.1]nonane (DPT) in nitric acid to prepare 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) has puzzled chemists for decades. In this paper, experimental work and theoretical calculation are described to investigate the long-standing challenge. The experiment results showed that ammonium nitrate or alkylammonium chlorides were in favor of the formation of 1-nitroso-3,5,7-trinitro-1,3,5,7-tetraazacyclooctane (MNX) but hindered the conversion of MNX to HMX. A plausible catalytic mechanism was proposed. In which ammonia or amines, in situ generated from the unfavorable balance with their salts, act as Lewis base catalysts. At the same time, the DFT computation results reveal that rigid bicyclic transition states established with 1-hydroxymethyl-3,5,7-trinitro-1,3,5,7-tetraazacyclooctane, ammonia (or amines) and three water molecules lead to very low activation energies. Then, a novel process for the preparation of MNX with excellent yield up to 78.5% was developed, which is free of the use of NaNO2 or N2O4 as nitroso resources.

Preparation of (S')-3,3,-bis-morpholinomethyl- 5,5',6,6',7,7',8,8'- octahydro-1,1,-BI-2-naphthol

Turlington, Mark,Pu, Lin,Kimmel, Kyle L.,Ellman, Jonathan A.

experimental part, p. 59 - 67 (2011/05/11)

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A simple method for the preparation of propargylamines using molecular sieve modified with copper(II)

Fodor, Anna,Kiss, Arpad,Debreczeni, Nora,Hell, Zoltan,Gresits, Ivan

scheme or table, p. 4575 - 4581 (2010/11/19)

A new, heterogeneous, 4 A molecular sieve-supported copper(ii) catalyst was developed and was used successfully in the A3 coupling of alkynes, aldehydes and amines under simple reaction conditions.

Tocopherols by hydride reduction of dialkylamino derivatives

Netscher, Thomas,Mazzini, Francesco,Jestin, Roselyne

, p. 1176 - 1183 (2008/02/08)

Aminomethylation with Mannich reagents derived from secondary amines and paraformaldehyde under improved conditions has been used to convert non-α-tocopherol homologues into α-tocopherol, the biologically most important vitamin E compound. Mono- and bis(aminomethylated) β-, γ-and δ-tocopherol were then subsequently transformed into the corresponding tocopherols (α- and β-tocopherol) by reductive deamination. As an alternative to classical catalytic hydrogenation in the last step, efficient laboratory protocols using complex hydrides have been derived and applied to the preparation of labelled vitamin E compounds. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Process route upstream and downstream products

Process route

β-morpholinyl-N,N-morpholinylpropionic acid amide
3773-84-0

β-morpholinyl-N,N-morpholinylpropionic acid amide

N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

N-Acryloylmorpholine
5117-12-4,28902-82-1

N-Acryloylmorpholine

Conditions
Conditions Yield
With 10H-phenothiazine; In 5,5-dimethyl-1,3-cyclohexadiene; at 110 ℃; for 12h; Inert atmosphere;
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

4-(morpholinomethyl)morpholine
5625-90-1

4-(morpholinomethyl)morpholine

Conditions
Conditions Yield
at 70 - 80 ℃; for 2.33333h; Title compound not separated from byproducts.;
at 60 ℃; for 13h; Cooling with ice;
at 20 - 65 ℃; for 13h;
paraformaldehyde

paraformaldehyde

N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

4-(morpholinomethyl)morpholine
5625-90-1

4-(morpholinomethyl)morpholine

Conditions
Conditions Yield
at 70 - 80 ℃; for 2h;
4-(morpholinomethyl)morpholine
5625-90-1

4-(morpholinomethyl)morpholine

N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

Conditions
Conditions Yield
With water; at 25 ℃; Equilibrium constant;
phenylacetylene
536-74-3

phenylacetylene

N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

4-(3-phenyl-prop-2-ynyl)-morpholine
1017-73-8

4-(3-phenyl-prop-2-ynyl)-morpholine

Conditions
Conditions Yield
With Mg:La (3:1) mixed oxide supported Cu(II); neat (no solvent);
42%
14%
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

4-(morpholinomethyl)morpholine
5625-90-1

4-(morpholinomethyl)morpholine

Conditions
Conditions Yield
at 25 ℃; Equilibrium constant;
With water; potassium carbonate;
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

methanediol
463-57-0

methanediol

Conditions
Conditions Yield
With water; at 25 ℃; Equilibrium constant;
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

water
7732-18-5

water

Conditions
Conditions Yield
at 20 ℃; Equilibrium constant;
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

1-Nitropropane
108-03-2

1-Nitropropane

4-(2-nitrobutyl)morpholine
2224-44-4

4-(2-nitrobutyl)morpholine

Conditions
Conditions Yield
With water;
N-hydroxymethylmorpholine
4432-43-3

N-hydroxymethylmorpholine

benzenesulfonamide
98-10-2

benzenesulfonamide

<i>N</i>-morpholin-4-ylmethyl-benzenesulfonamide
4392-61-4

N-morpholin-4-ylmethyl-benzenesulfonamide

Conditions
Conditions Yield
With water;

Global suppliers and manufacturers

Global( 4) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Debye Scientific
  • Business Type:Trading Company
  • Contact Tel:00852-21376140
  • Emails:sales@debyesci.com
  • Main Products:13
  • Country:China (Mainland)
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