15622-65-8

Usage

Uses

Used in Pharmaceutical Industry:
MOLINDONE HYDROCHLORIDE (500 MG) is used as an antipsychotic agent for the treatment of schizophrenia and other psychotic disorders. It works by blocking dopamine receptors in the brain, which helps to alleviate the symptoms of these conditions.
MOLINDONE HYDROCHLORIDE (500 MG) is also used as a dopamine receptor antagonist for managing the symptoms of Tourette's syndrome and other hyperkinetic movement disorders. Its ability to modulate dopamine levels in the brain makes it an effective treatment option for these conditions.
Additionally, MOLINDONE HYDROCHLORIDE (500 MG) is used as a monoamine oxidase (MAO) inhibitor, which helps to increase the levels of certain neurotransmitters in the brain, such as serotonin, norepinephrine, and dopamine. This can be beneficial for individuals suffering from depression or other mood disorders.
Brand Name:
The brand name for MOLINDONE HYDROCHLORIDE (500 MG) is Moban, which is manufactured by Endo Pharmaceuticals.

Originator

Moban,Endo,US,1974

Manufacturing Process

Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2- methyl-4-oxoindole.3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol) were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to dryness in vacuo on a steam bath and the residue digested with a mixture of 150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting material was filtered off. To the acid solution, ammonia water was added dropwise with stirring and the amine crystallized out. It was purified by dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl- 4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.

Therapeutic Function

Antipsychotic

InChI:InChI=1/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H

Upstream product

• 107-87-9 2-Pentanone 
• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 6116-76-3 3-ethyl-2-methyl-4-oxo-1H-4,5,6,7-tetrahydroindole 
• 815-48-5 3-bromopentan-2-one 
• 130000-33-8 methyl 2-chloro-2-ethyl-3-oxobutanoate 
• 4432-43-3 N-hydroxymethylmorpholine 
• 10024-89-2 morpholin hydrochloride 
• 504-02-9 1,3-cylohexanedione 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF MOLINDONE

The present invention provides process for preparation of molindone (I) comprising: a) reacting compound with cyclohexane-1,3-dione to form 2-(2-oxopentan-3-yl)cyclohexane-1,3-dione wherein X is Cl, Br or I, b) cyclizing 2-(2-oxopentan-3-yl)cyclohexane-1,

Improved synthesizing method of molindone

The invention relates to the field of medicine synthesizing, and particularly relates to an improved synthesizing method of molindone. The improved synthesizing method of the molindone comprises the following steps of (1) under the condition of existence of an alcohol solvent and an ore acid catalyst, enabling 2-methyl-3-ethyl-4,5,6,7-tetrehydro indole-4-ketone, morpholine hydrochloride and paraformaldehyde to perform aminomethylation reaction at the temperature of 50 to 55 DEG C under the condition of refluxing reaction, so as to generate molindone hydrochloride; (2) separating out the unreacted raw material, namely 2-methyl-3-ethyl-4,5,6,7-tetrehydro indole ketone, and alkalifying a mother liquid, so as to directly obtain the molindone. The improved synthesizing method has the advantages that the usage amount of solvent in the Mannich reaction is reduced by times, the aminomethylation reaction time is greatly shortened, the subsequent impurity removal separation process is simplified, the yield rate is high, the cost is low, the production environment is obviously improved, the treatment cost of three wastes is low, and the comprehensive advantages are obvious.