4432-63-7

Basic information

• Product Name: Atropaldehyde
• Synonyms: Atropaldehyde;2-Phenyl-2-propene-1-al;2-Phenylacrylaldehyde;2-Phenylpropenal;Benzeneacetaldehyde, .alpha.-Methylene-
• CAS NO: 4432-63-7
• Molecular Formula: C₉H₈O
• Molecular Weight: 132.15922
• Mol File: 4432-63-7.mol
• Article Data: 50

Chemical Properties

• Boiling Point: 260 °C at 760 mmHg
• Flash Point: 86.5 °C
• Appearance: /
• Density: 0.996 g/cm³
• CAS DataBase Reference: Atropaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Atropaldehyde(4432-63-7)
• EPA Substance Registry System: Atropaldehyde(4432-63-7)

Safety Data

• Hazardous Substances Data: 4432-63-7(Hazardous Substances Data)

Usage

Description

Atropaldehyde is a chemical compound that serves as a precursor to atropine, a medication with various therapeutic applications. It is also a breakdown product of acetylcholine, a neurotransmitter that plays a crucial role in the regulation of bodily functions. Atropaldehyde has garnered significant interest in the medical and pharmaceutical fields due to its potential therapeutic uses, particularly in treating disorders related to the nervous system and muscle function. Furthermore, research is being conducted to explore its role in the development of new drugs and treatments for a range of medical conditions.

Uses

Used in Pharmaceutical Industry:
Atropaldehyde is used as a precursor for the synthesis of atropine, which is a medication for treating nerve agent and pesticide poisonings, as well as certain types of slow heart rate. It also helps in decreasing secretions such as saliva and stomach acid.
Atropaldehyde is used as a research compound for exploring its potential therapeutic uses in the treatment of disorders related to the nervous system and muscle function. Its involvement in the regulation of various bodily functions makes it a promising candidate for developing new drugs and treatments for various medical conditions.
Used in Medical Research:
Atropaldehyde is used as a subject of research in the medical field to understand its role in the regulation of bodily functions and its potential applications in the development of new drugs and treatments for various medical conditions. Its connection to acetylcholine, a neurotransmitter, makes it an interesting area of study for scientists working on nervous system-related disorders and muscle function.

Upstream product

• 50-00-0 formaldehyd 
• 122-78-1 phenylacetaldehyde 
• 4393-06-0 1-Phenyl-2-propen-1-ol 
• 75700-24-2 3-phenyloxete 
• 98-83-9 isopropenylbenzene 
• 80234-04-4 2-phenylacrylaldehyde diethyl acetal 
• 100-42-5 styrene 
• 68-12-2 N,N-dimethyl-formamide 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 109141-70-0 1-(1-methoxyprop-1-en-2-yl)benzene 
• 51425-55-9 (E)-dihydrocinnamaldehyde trimethyl silyl enol ether 
• 3600-18-8 ethyl α-bromoacetoacetate 
• 936474-98-5 tert-butyl-dimethyl-(2-phenyl-allyloxy)-silane 

Downstream Products

• 1125-70-8 2-phenylpropanamide 
• 97728-02-4 2-phenyl-1-hexen-5-yn-3-ol 
• 78593-99-4 2-Phenyl-3-phenylsulfanyl-propionaldehyde 
• 677325-07-4 dihydro-3-(1-oxo-2-phenyl-2-propenyl)furan-2-one 
• 677325-09-6 3,5,6,7-tetrahydro-7-phenylfuro[3,2-c]pyridin-4-one 
• 492-38-6 2-phenylacrylic acid 
• 178817-64-6 [1-2H]-2-phenyl-2-propen-1-ol 
• 53847-15-7 5-phenylhexa-1,5-dien-3-ol 
• 162660-53-9 4-(dioxolan-2-yl)-2-methyl-2-nitro-4-phenylbutane 
• 162660-52-8 4-methyl-4-nitro-2-phenylvaleraldehyde 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 149379-74-8 2-methoxy-5-phenylpyridine-3-carbonitrile 
• 149379-78-2 2-amino-5-phenylbenzene-1,3-dicarbonitrile 

Relevant articles and documents

Synthesis of the cis diastereoisomer of 5-diethoxyphosphoryl-5-methyl-3- phenyl-1-pyrroline N-oxide (DEPMPPOc) and ESR study of its superoxide spin adduct

The cis and trans diastereoisomers of 5-diethoxyphosphoryl-5-methyl-3- phenyl-1-pyrroline N-oxide (DEPMPPO), the C(3)-phenyl analogue of DEPMPO, were prepared in three steps from phenylacetaldehyde and used in ESR-spin trapping of various carbon-, oxygen- and sulfur-centred radicals. In the case of the cis-isomer, the presence of the phenyl group cancels the alternating line width phenomenon observed for the DEPMPO-OOR (R = H, But) spin adducts. The ESR spectra of the DEPMPPOc-OOR spin adducts exhibit more straightforward patterns and are more easily assignable.

Two C=C Bond Participation in Annulation to Pyridines Based on DMF as the Nonadjacent N and C Atom Donors

Two C=C bond participation in annulation to pyridines using N,N-dimethylformamide (DMF) as the N1 and C4 synthons has been carried out. In this reaction, DMF contributed one N atom and one C atom to two disconnected positions of pyridine ring, with no need for an additional nitrogen source. Two C=C bonds in two molecules of substituted styrenes offered four carbon atoms in the presence of iodine and persulfate. With the optimized conditions in hand, both symmetric and unsymmetric diaryl-substituted pyridines were obtained in useful yields. On the basis of relevant literature and a series of control experimental results, a possible mechanism was proposed in this work, which may demonstrate how DMF provides both N1 and C4 sources.

Method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and diphosphine ligand used in method

The invention discloses a method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and a diphosphine ligand used in the method. According to the invention, indole-substituted phosphoramidite diphosphine ligand which is stable in air and insensitive to light is synthesized by utilizing a continuous one-pot method, and the indole-substituted phosphoramidite diphosphine ligand and a rhodium catalyst are used for jointly catalyzing to successfully achieve a hydroformylation reaction of aromatic terminal alkyne and terminal conjugated eneyne under the condition of synthesis gas for the first time, so that an olefine aldehyde structure compound can be rapidly and massively prepared, and particularly, a polyolefine aldehyde structure compound which is more difficult to synthesize in the prior art can be easily prepared and synthesized, and a novel method is provided for synthesis and modification of drug molecules, intermediates and chemical products.

Method for preparing olefine aldehyde through catalytic oxidation of enol ether

The invention relates to the technical field of olefine aldehyde preparation, and provides a method for preparing olefine aldehyde through catalytic oxidation of enol ether. According to the invention, a palladium catalyst, a copper salt, a solvent and enol ether are mixed and subjected to a catalytic oxidation reaction to obtain olefine aldehyde. According to the method, the copper salt is used as the oxidizing agent, the mixed solvent of water and acetonitrile is used as the reaction solvent, and the volume ratio of water to acetonitrile in the mixed solvent is controlled to be (3-7): (3-7), so that the catalytic oxidation reaction can be smoothly carried out in the mixed solvent with a specific ratio, and the generation of palladium black precipitate can be avoided. The method provided by the invention has the advantages of simple steps, low reagent cost, no need of dangerous reagents, wide substrate adaptability and small catalyst dosage. Furthermore, octadecane mercaptan is added to promote the catalytic oxidation reaction, and when the dosage of the palladium catalyst is extremely low, the olefine aldehyde yield can be greatly increased by adding octadecane mercaptan.