4444-68-2

Basic information

• Product Name: N,N-DIETHYLBUTYLAMINE
• Synonyms: N,N-DIETHYLBUTYLAMINE;1-Butanamine,N,N-diethyl-;Butylamine, N,N-diethyl-;Butylamine,N,N-diethyl-;diethylbutylamine;Ethanamine, N-butyl-N-ethyl-;Ethanamine,N-butyl-N-ethyl-;N,N-Diethyl-1-butanamine
• CAS NO: 4444-68-2
• Molecular Formula: C₈H₁₉N
• Molecular Weight: 129.24
• Product Categories: Amines;C8;Nitrogen Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 4444-68-2.mol

Chemical Properties

• Melting Point: 136-137℃
• Boiling Point: 136.5 °C(lit.)
• Flash Point: 24 °C
• Appearance: /
• Density: 0.748 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.98mmHg at 25°C
• Refractive Index: n20/D 1.414(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N,N-DIETHYLBUTYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIETHYLBUTYLAMINE(4444-68-2)
• EPA Substance Registry System: N,N-DIETHYLBUTYLAMINE(4444-68-2)

Safety Data

• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 16-26-27-36/37/39-45
• RIDADR: 2733
• WGK Germany: 3
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 4444-68-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
N,N-Diethylbutylamine is used as a reagent for the regioselective syntheses of 6-(1,1-dimethylallyl) ortho-flavones. Its specific structural features enable it to participate in targeted chemical reactions, leading to the formation of desired products with high selectivity.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N,N-diethylbutylamine is used as a key intermediate in the synthesis of N,N-diethylbutylammonium bis(trifluoromethylsulfonyl)imide, which is an ionic liquid with potential applications in drug delivery and development.
These applications highlight the versatility of N,N-diethylbutylamine in different fields, particularly in chemical synthesis and pharmaceuticals, where its unique properties contribute to the development of new compounds and products.

Air & Water Reactions

Highly flammable. N,N-DIETHYLBUTYLAMINE may be unstable to prolonged exposure to air. . Insoluble in water.

Reactivity Profile

N,N-DIETHYLBUTYLAMINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: N,N-DIETHYLBUTYLAMINE is flammable and should be kept away from any heat source of heat or ignition.

Fire Hazard

The flash point of N,N-DIETHYLBUTYLAMINE has not been determined, but N,N-DIETHYLBUTYLAMINE is probably flammable.

InChI:InChI=1/C8H19N/c1-4-7-8-9(5-2)6-3/h4-8H2,1-3H3

Upstream product

• 75-04-7 ethylamine 
• 123-73-9 crotonaldehyde 
• 811-49-4 ethyllithium 
• 13028-69-8 butyltriethylammonium hydrogen sulfate 
• 123-91-1 1,4-dioxane 
• 61391-28-4 1-benzoyloxy-4-diethylamino-but-2-yne; hydrochloride 
• 64-17-5 ethanol 
• 109-73-9 N-butylamine 
• 60-29-7 diethyl ether 
• 121-44-8 triethylamine 

Downstream Products

• 1126-78-9 N-(n-butyl)aniline 
• 103-69-5 N-ethyl-N-phenylamine 
• 29397-20-4 (E)-N'-((4-methylphenyl)sulfonyl)-N,N-diethylformimidamide 
• 5467-48-1 4-(diethylamino)-2-butanol 
• 2683-56-9 4-(N,N-diethylamino)-1-butanol 
• 13028-69-8 butyltriethylammonium hydrogen sulfate 

Relevant articles and documents

Alkyl coupling in tertiary amines as analog of Guerbet condensation reaction

We report here that C-C coupling in tertiary amines for the synthesis of long chain and hindered amines might be efficiently performed over Pt and Pd catalysts. The mechanism study confirms similarity with the Guerbet reaction through dehydrogenation of the alkyl group and subsequent attack of the α-carbon atom by an alkyl group of another molecule. Finally, secondary amines and tertiary amines with longer alkyl chains are formed.

The synthesis of N-ethyl-n-butylamine by amines disproportionation

A synthesis of N-ethyl-n-butylamine with simple separation method in a fixed-bed reactor using CuO-NiO-PtO/γ-Al2O3 as the catalyst was proposed and investigated. The present catalytic system gave high activity and good selectivity, and the reaction conditions such as temperature and liquid hourly space velocity were optimized. Since no water was generated, the protocol proved to be easy to separate, and N-ethyl-n-butylamine was collected at 110 °C by distillation. The yield and the purity were 60.7 and 99.5 %, respectively.

A novel method for N-alkylation of aliphatic amines with ethers over ?3-Al2O3

A novel and simple method for the N-alkylation of amines with different ethers as alkylating reagents has been developed, using cheap ?3-Al2O3 as the catalyst at atmospheric pressure in the temperature range of 260-320?°C. For example, the reaction of equ