500011-88-1

Basic information

• Product Name: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE
• Synonyms: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE;Ethyl 2-(3-Chloro-2-Pyridinyl)-5-Oxo-3-Pyrazolidinecarboxylate;ethyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate
• CAS NO: 500011-88-1
• Molecular Formula: C₁₁H₁₂ClN₃O₃
• Molecular Weight: 269.68
• Mol File: 500011-88-1.mol
• Article Data: 40

Chemical Properties

• Melting Point: 132-134 °C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 0-0Pa at 20-50℃
• Refractive Index: 1.566
• PKA: 10.77±0.40(Predicted)
• CAS DataBase Reference: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE(500011-88-1)
• EPA Substance Registry System: ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE(500011-88-1)

Safety Data

• Hazardous Substances Data: 500011-88-1(Hazardous Substances Data)

Usage

General Description

Ethyl 1-(3-chloro-2-pyridinyl)-3-pyrazolidinone-5-carboxylate is a chemical compound with the molecular formula C12H13ClN2O3. It is a pyridine derivative with a pyrazolidinone core and an ethyl ester functional group. ETHYL 1-(3-CHLORO-2-PYRIDINYL)-3-PYRAZOLIDINONE-5-CARBOXYLATE has the potential to exhibit various biological activities due to its structural characteristics, including antifungal, antibacterial, and anti-inflammatory properties. It may also have applications in the pharmaceutical industry as a potential drug candidate for the treatment of various diseases and conditions. Additionally, its unique structure and functional groups make it an interesting target for further research and development in medicinal chemistry and drug discovery.

InChI:InChI=1/C11H12ClN3O3/c1-2-18-11(17)8-6-9(16)14-15(8)10-7(12)4-3-5-13-10/h3-5,8H,2,6H2,1H3,(H,14,16)

Upstream product

• 22841-92-5 (3-chloro-2-pyridyl)hydrazine 
• 141-05-9 Diethyl maleate 
• 1520-50-9 but-2-enedioic acid diethyl ester 
• 623-91-6 diethyl Fumarate 
• 64-17-5 ethanol 
• 22841-92-5 3-chloro-2(1H)-pyridinone hydrazone 
• 2402-77-9 2,3-dichloro-pyridine 
• 141-52-6 sodium ethanolate 
• 500011-91-6 5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester 

Downstream Products

• 500011-91-6 5-bromo-2-(3-chloro-pyridin-2-yl)-3,4-dihydro-2H-pyrazole-3-carboxylic acid ethyl ester 
• 500011-86-9 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid 
• 500011-92-7 5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazole-3-carboxylic acid ethyl ester 
• 1410073-12-9 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-nitrophenyl)-1H-pyrazole-5-carboxamide 
• 1262305-51-0 3-bromo-1-(3-chloropyridin-2-yl)-N-(4-ethoxyphenyl)-1H-pyrazole-5-carboxamide 
• 1410073-27-6 3-bromo-N-(2-chloro-4-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-30-1 3-bromo-N-(2-bromo-4-nitrophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-32-3 3-bromo-N-(2-nitro-4-chlorophenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-34-5 3-bromo-1-(3-chloropyridin-2-yl)-N-(2,5-dichlorophenyl)-1H-pyrazole-5-carboxamide 
• 1410073-35-6 3-bromo-N-(4-chloro-2,6-dimethylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1410073-38-9 3-bromo-N-(4-bromo-2,6-dimethylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1401724-13-7 3-chloro-N-(4-chloro-2-((5-(diethylamino)pentan-2-yl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1401724-14-8 3-bromo-N-(4-chloro-2-((5-(diethylamino)pentan-2-yl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1079956-75-4 3-bromo-N-(4-chloro-2-((2-(dimethylamino)ethyl)carbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 

Relevant articles and documents

Preparation method of pyridyl pyrazolidinone carboxylic acid compound

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of a pyridyl pyrazolidinone carboxylic ester compound. The reaction formula is shown in the specification, each group in the formula being defined in the specification. The invention provides a method for preparing a key intermediate pyridyl pyrazolidinone carboxylic ester compound of benzamide insecticides, and by adopting the method provided by the invention, the yield of a product is improved, the energy consumption is reduced, and industrial production is facilitated.

Diamides conformationally restricted with central amino acid: Design, synthesis, and biological activities

Diamide insecticides, represented by chlorantraniliprole (CHL), were widely applied in the control of lepidopteran insects. In efforts to develop bioactive diamides with novel scaffolds, we design and synthesized a series of diamides containing central amino acids to conformationally simulate CHL. Bioassay results indicated that most compounds containing 1-aminocyclopropane-1-carboxylic acid exhibited excellent larvacidal potency against Mythimna separate and Plutella xylostella. After a systematic structure–activity relationship study, 1–23 was identified as a potential insecticidal candidate with LC50 values of 34.920 mg·L?1 against M. separate and 61.992 mg·L?1 on P. xylostella. Finally, molecular docking revealed the possible binding mode of 1–23 with the target protein, ryanodine receptors.

N-ALKYL-N-CYANOALKYLBENZAMIDE COMPOUND AND USE THEREOF

The present invention discloses an N-alkyl-N-cyanoalkylbenzamide compound of General Formula I, an intermediate of General Formula II used to prepare the compound, wherein R1 is selected from halo or C1-C3 alkyl; R2