5031-83-4

Basic information

• Product Name: 2,4-diphenylcrotonaldehyde
• Synonyms: 2,4-diphenylcrotonaldehyde;2,4-Diphenyl-2-butenal;α-(2-Phenylethylidene)benzeneacetaldehyde
• CAS NO: 5031-83-4
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.28176
• EINECS: 225-723-0
• Mol File: 5031-83-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 391.8°C at 760 mmHg
• Flash Point: 154.8°C
• Appearance: /
• Density: 1.067g/cm³
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2,4-diphenylcrotonaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-diphenylcrotonaldehyde(5031-83-4)
• EPA Substance Registry System: 2,4-diphenylcrotonaldehyde(5031-83-4)

Safety Data

• Hazardous Substances Data: 5031-83-4(Hazardous Substances Data)

Usage

General Description

2,4-diphenylcrotonaldehyde is a chemical compound with the molecular formula C17H14O. It is a pale yellow liquid with a honey-like odor, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 2,4-diphenylcrotonaldehyde is also known for its ability to inhibit the growth of cancer cells, making it a potential candidate for anti-cancer drug development. It is considered to be a hazardous chemical and should be handled with care, as it can irritate the skin, eyes, and respiratory system upon contact or inhalation. Additionally, it is flammable and should be stored and used in a well-ventilated area with appropriate safety precautions in place.

InChI:InChI=1/C16H14O/c17-13-16(15-9-5-2-6-10-15)12-11-14-7-3-1-4-8-14/h1-10,12-13H,11H2/b16-12-

Upstream product

• 96-09-3 styrene oxide 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 201230-82-2 carbon monoxide 
• 4980-70-5 1,3-diphenyl-1-propyne 
• 591-50-4 iodobenzene 
• 10147-11-2 propargyl benzene 
• 122-78-1 phenylacetaldehyde 
• 6324-00-1 1-amino-2-phenylethanephosphonic acid 
• 7646-78-8 tin(IV) chloride 
• 2425-28-7 2-Bromo-1-phenylethanol 
• 93-56-1 phenylethane 1,2-diol 
• 100-52-7 benzaldehyde 
• 108471-39-2 2-Morpholin-4-yl-5-phenyl-[1,3]oxazin-6-one 
• 17147-69-2 4-phenylisoxazol-5(2H)-one 

Downstream Products

• 14195-22-3 3-benzyl-4-phenyl-1H-pyrazole 
• 1081-75-0 1,3-diphenylpropane 
• 3412-44-0 1,3-diphenylpropene 

Relevant articles and documents

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H4SiW12O40-catalyzed cyclization of epoxides/aldehydes and sulfonyl hydrazides: An efficient synthesis of 3,4-disubstituted 1H-pyrazoles

A simple and efficient method for the synthesis of pyrazoles through a silicotungstic acid (H4SiW12O40)-catalyzed cyclization of epoxides/aldehydes and sulfonyl hydrazides has been developed. Various epoxides/aldehydes were smoothly reacted with sulfonyl hydrazides to furnish regioselectivity 3,4-disubstituted 1H-pyrazoles. The application of such an earth-abundant, readily accessible, and nontoxic catalyst provides a green approach for the construction of 3,4-disubstituted 1H-pyrazoles. A plausible reaction mechanism has been proposed on the basis of control experiments, GC-MS and DFT calculations.

SELF-CONDENSATION OF ALDEHYDES

An efficient process useful for the self-condensation of aliphatic aldehydes is provided, catalyzed by dialkylammonium carboxylate salts. In particular, the invention provides a facile method for the preparation of 2-ethyl hexenal via the self-condensation of butyraldehyde using various dialkylammonium carboxylates, e.g., diisopropylammonium acetate or dimethylammonium acetate, as catalyst. Additionally, residual nitrogen arising from the catalyst can be reduced to -100 ppm levels in the product via a simple washing procedure. The invention provides a process for preparing alkenals under conditions which limit the formation of undesired impurities and high-boiling oligomeric substances.