508177-67-1

Basic information

• Product Name: Benzenemethanamine, 4-fluoro-3-methoxy- (9CI)
• Synonyms: Benzenemethanamine, 4-fluoro-3-methoxy- (9CI);(4-Fluoro-3-methoxyphenyl)methanamine;5-Aminomethyl-2-fluoroanisole;4-Fluoro-3-MethoxybenzylaMine HCl;Benzenemethanamine, 4-fluoro-3-methoxy-;4-Fluoro-3-methoxybenzenemethanamine
• CAS NO: 508177-67-1
• Molecular Formula: C₈H₁₀FNO
• Molecular Weight: 155.1695032
• Product Categories: METHOXY;HALIDE
• Mol File: 508177-67-1.mol

Chemical Properties

• Boiling Point: 242.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.127±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: 8.98±0.10(Predicted)
• CAS DataBase Reference: Benzenemethanamine, 4-fluoro-3-methoxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-fluoro-3-methoxy- (9CI)(508177-67-1)
• EPA Substance Registry System: Benzenemethanamine, 4-fluoro-3-methoxy- (9CI)(508177-67-1)

Safety Data

• Hazardous Substances Data: 508177-67-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Benzenemethanamine, 4-fluoro-3-methoxy(9CI) is used as a research chemical for the development of new pharmaceuticals. Its unique structure and properties make it a valuable compound for studying the effects of various modifications on its activity and potential therapeutic applications.
Used in Neuropharmacological Research:
Benzenemethanamine, 4-fluoro-3-methoxy(9CI) is used in neuropharmacological research to investigate its effects on the central nervous system. Its stimulant and psychoactive properties provide insights into the mechanisms of action of similar compounds and their potential applications in the treatment of neurological disorders.
Used in the Study of Stimulant Effects:
Benzenemethanamine, 4-fluoro-3-methoxy(9CI) is used to study the effects of stimulants on physiological and psychological functions. Its ability to increase energy, alertness, and cognitive function can help researchers understand the underlying mechanisms of these effects and develop safer and more effective stimulant medications.
Used in the Development of Cognitive Enhancers:
Due to its cognitive-enhancing properties, this compound is used in the development of new cognitive enhancers. It can provide valuable information on the molecular targets and pathways involved in cognitive function, leading to the discovery of novel therapeutic agents for the treatment of cognitive disorders.
Used in Toxicological Studies:
Benzenemethanamine, 4-fluoro-3-methoxy(9CI) is also used in toxicological studies to evaluate the safety and potential side effects of similar compounds. Understanding its toxicological profile can help in the design of safer and more effective drugs with reduced side effects.

Upstream product

• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 243128-37-2 4-fluoro-3-methoxybenzonitrile 

Relevant articles and documents

Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists?

A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n = 1-3). β-Dimethyl and α-methyl

Targeted Polypharmacology: Discovery of a Highly Potent Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-10/-13 Inhibitor

Matrix metalloproteinases (MMPs) play a key role in many diseases like cancer, atherosclerosis or arthritis. Interest in MMP inhibition has been revitalized very recently as the knowledge on the underlying network of biological pathways is steadily growing. On the basis of this new insight into the relevance of MMP-10 and MMP-13 within the MMP network and the ban of hydroxamate inhibitors from clinical development, the discovery of non-hydroxamate multitarget drugs against specific MMPs is of foremost interest. Here, we disclose the discovery of a very potent and selective non-hydroxamate MMP-10/-13 inhibitor. The high potency (IC50 of 31 nM [MMP-10] and 5 nM [MMP-13]) and selectivity over MMP-1, -2, -3, -7, -8, -9, -12, and -14 enable this compound to decipher disease causing MMP networks and to generate new treatment options through targeted polypharmacology.

TROPANE COMPOUNDS

A compound according to Formula I or II: (I) or (II) wherein R1, R1b, R2, L1, and L2 and L2b are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

LIGANDS FOR IMAGING CARDIAC INNERVATION

Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.