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523-64-8

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523-64-8 Usage

Description

Flindersine, a limonoid phytochemical derived from the plant Flindersia acuminata, exhibits a range of biological activities such as cytotoxic, anti-inflammatory, and anti-malarial properties. As a natural product, it holds promise for drug development in cancer treatment and infectious diseases, with its pharmacological activities and mechanisms of action being subjects of ongoing research and development.

Uses

Used in Pharmaceutical Industry:
Flindersine is used as a cytotoxic agent for its potential in cancer treatment, targeting and eliminating cancer cells while causing minimal harm to healthy cells.
Used in Anti-inflammatory Applications:
Flindersine serves as an anti-inflammatory compound, helping to reduce inflammation and associated symptoms in various conditions.
Used in Anti-malarial Treatment:
Flindersine is utilized as an anti-malarial agent, combating malaria-causing parasites and alleviating the disease's effects.
Used in Drug Development:
Flindersine's diverse pharmacological activities make it a valuable candidate for the development of new drugs targeting a range of diseases, including cancer and infectious diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 523-64-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,2 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 523-64:
(5*5)+(4*2)+(3*3)+(2*6)+(1*4)=58
58 % 10 = 8
So 523-64-8 is a valid CAS Registry Number.
InChI:InChI=1/C14H13NO2/c1-14(2)8-7-10-12(17-14)9-5-3-4-6-11(9)15-13(10)16/h3-8H,1-2H3,(H,15,16)

523-64-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-dimethyl-6H-pyrano[3,2-c]quinolin-5-one

1.2 Other means of identification

Product number -
Other names Flindersine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:523-64-8 SDS

523-64-8Relevant articles and documents

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de Groot,A.,Jansen,B.J.M.

, p. 3407 - 3410 (1975)

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Euodenine A: A small-molecule agonist of human TLR4

Neve, Juliette E.,Wijesekera, Hasanthi P.,Duffy, Sandra,Jenkins, Ian D.,Ripper, Justin A.,Teague, Simon J.,Campitelli, Marc,Garavelas, Agatha,Nikolakopoulos, George,Le, Phuc V.,De A. Leone, Priscila,Pham, Ngoc B.,Shelton, Philip,Fraser, Neil,Carroll, Anthony R.,Avery, Vicky M.,McCrae, Christopher,Williams, Nicola,Quinn, Ronald J.

, p. 1252 - 1275 (2014/03/21)

A small-molecule natural product, euodenine A (1), was identified as an agonist of the human TLR4 receptor. Euodenine A was isolated from the leaves of Euodia asteridula (Rutaceae) found in Papua New Guinea and has an unusual U-shaped structure. It was synthesized along with a series of analogues that exhibit potent and selective agonism of the TLR4 receptor. SAR development around the cyclobutane ring resulted in a 10-fold increase in potency. The natural product demonstrated an extracellular site of action, which requires the extracellular domain of TLR4 to stimulate a NF-κB reporter response. 1 is a human-selective agonist that is CD14-independent, and it requires both TLR4 and MD-2 for full efficacy. Testing for immunomodulation in PBMC cells shows the induction of the cytokines IL-8, IL-10, TNF-α, and IL-12p40 as well as suppression of IL-5 from activated PBMCs, indicating that compounds like 1 could modulate the Th2 immune response without causing lung damage.

Simple efficient synthesis of pyranoquinoline alkaloids: Flindersine, khaplofoline, haplamine and their analogues

Thangavel, Dhanabal,Ravindran, Sangeetha,Moonsamy, Gengan Robert,Palathurai, Mohan Subramaniam

, p. 124 - 126 (2008/02/11)

An efficient two step synthesis of pyranoquinoline alkaloids is described. Direct treatment of isoprene with 4-hydroxyquinolin-2(1H)-one in the presence of polyphosphoric acid furnished dihydroflindersine in good yield, and which on dehydrogenation led to a new synthesis of flindersine. Khaplofoline, a linear pyranoquinoline alkaloid, was obtained as a minor product. The syntheses of derivatives are also documented.

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