52559-90-7Relevant articles and documents
Crown-annelated oligothiophenes as model compounds for molecular actuation
Jousselme, Bruno,Blanchard, Philippe,Levillain, Eric,Delaunay, Jacques,Allain, Magali,Richomme, Pascal,Rondeau, David,Gallego-Planas, Nuria,Roncali, Jean
, p. 1363 - 1370 (2007/10/03)
Crown-annelated quater- (4T) and sexithiophenes (6T) with oligooxyethylene chains of various lengths attached at the 3-positions of the terminal thiophene rings have been synthesized. Analysis of the cation-binding properties of the macrocycles by 1H NMR and UV-vis spectroscopy reveals the formation of a 1:1 complex with Ba2+, Sr2+, or Pb2+ and shows that cation complexation results in a conformational transition in the π-conjugated system. Theoretical analysis of this process by density functional methods predicts that this conformational transition results in a narrowing of the highest occupied-lowest unoccupied molecular orbital gap of the conjugated system with a decrease of the redox potentials (E01 and E02) associated with the formation of the 4T cation radical and dication. Cyclic voltammetry shows that, depending on the binding constant, the presence of metal cation produces a negative or a positive shift of E01 while E02 always shifts negatively. This unusual behavior is discussed in terms of interplay between electrostatic interactions and conformational changes associated with cation binding.
Alkylated styrenes as prodrugs to COX-2 inhibitors
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, (2008/06/13)
The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
Ion selective fluorogenic reagents
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, (2008/06/13)
Novel fluorogenic ionophores have been synthesized which selectively bind ions such as potassium and sodium, even in neutral aqueous and alcoholic media and respond to such binding by fluorescence quenching or enhancement. These ionophores are ideal for the selective and direct determination of ions in biological or environmental samples and the like. The ionophores are also suitable for incorporation into fiber optic-based sensors for the continuous in vivo or in vitro monitoring of metal ions in blood or other biological fluids.