5434-21-9

Basic information

• Product Name: 4-Aminophthalic acid
• Synonyms: 4-Amino-o-phthalic acid;4-Aminophthalic acid,97%;4- aMinobenzene two forMic acid;4-Aminophthalic Acid(Contains 3-Aminophthalic Acid);4-amino-2-benzenedicarboxylicacid;AKOS 92080;4-AMINOPHTHALIC ACID;RARECHEM AL BO 1135
• CAS NO: 5434-21-9
• Molecular Formula: C₈H₇NO₄
• Molecular Weight: 181.15
• EINECS: 226-596-4
• Product Categories: Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives;Phthalic Acids, Esters and Derivatives;Organic acids
• Mol File: 5434-21-9.mol

Chemical Properties

• Melting Point: 344 °C (dec.)(lit.)
• Boiling Point: 465.1 °C at 760 mmHg
• Flash Point: 235.1 °C
• Appearance: Beige powder
• Density: 1.551 g/cm³
• Vapor Pressure: 1.88E-09mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.41±0.10(Predicted)
• BRN: 2723405
• CAS DataBase Reference: 4-Aminophthalic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminophthalic acid(5434-21-9)
• EPA Substance Registry System: 4-Aminophthalic acid(5434-21-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 5434-21-9(Hazardous Substances Data)

Usage

Chemical Properties

Beige powder

InChI:InChI=1/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)/p-2

Upstream product

• 2307-00-8 4-amino-N-methylphthalimide 
• 610-27-5 4-nitrophthalic acid 
• 7647-01-0 hydrogenchloride 
• 31643-49-9 4-Nitrophthalonitrile 
• 610-22-0 dimethyl 4-nitrophthalate 
• 85-44-9 phthalic anhydride 
• 1609672-16-3 ethyl 5-benzamido-2-(trifluoromethyl)benzoate 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Downstream Products

• 89-20-3 4-chlorophthalic acid 
• 99-05-8 meta-aminobenzoic acid 
• 20871-03-8 4-amino-N-phenylphthalimide 
• 59529-53-2 4-(4-Nitro-benzoylamino)-phthalic acid 

Relevant articles and documents

Metal organic framework material loaded with tetrakis-(N-methylallylamine)phthalocyanine compound, and preparation method and application thereof

The invention relates to the technical field of preparation of phthalocyanine compounds, in particular to a metal organic framework material loaded with a tetrakis-(N-methylallylamine)phthalocyanine compound, and a preparation method and application thereof. The metal organic framework material loaded with the tetrakis-(N-methylallylamine)phthalocyanine compound is composed of the tetrakis-(N-methylallylamine)phthalocyanine compound and a ZIF-series metal organic framework material, wherein the tetrakis-(N-methylallylamine)phthalocyanine compound is encapsulated in the ZIF-series metal organicframework material. The metal organic framework material loaded with a tetrakis-(N-methylallylamine)phthalocyanine compound of the invention effectively overcomes the problem that phthalocyanine molecular aggregate, as an anti-cancer photosensitizer or a photothermal conversion agent, does not dissolve or disperse in an aqueous phase system in the prior art, successfully realizes red shifting ofan absorption peak to a near-infrared region (700 nm), solves the problem that phthalocyanine molecules cannot be used for deep tumor treatment in the prior art, and is beneficial for deep treatment of tumors.

Specific fluorescence labeling of target proteins by using a ligand-4-azidophthalimide conjugate

We herein propose a simple affinity-labeling method using a ligand-4-azidophthalimide (AzPI) conjugate. As a proof of concept, we show that two different ligand-AzPI conjugates enabled highly specific fluorescence labeling of their individual target proteins even in crude cell lysates. This method was also applied to label endogenous target proteins inside living cells.

Diels-Alder reaction of ethyl 3-benzamido-2-oxo-6-(trifluoromethyl)-2H- pyran-5-carboxylate with alkoxyalkenes as an effective approach to trifluoromethyl-containing 3-aminobenzoic acid derivatives

The Diels-Alder reactions of ethyl 3-benzamido-2-oxo-6-(trifluoromethyl)- 2H-pyran-5-carboxylate with ethyl vinyl ether, 2-methoxypropene, and 1-ethoxypropene were investigated. Under different reaction conditions, intermediate oxabicyclo[2.2.2]octenones,

Design, synthesis and in-vitro cytotoxicity of novel platinum (II) complexes with phthalate as the leaving group

Three platinum (II) complexes (6-8) with phthalate as the leaving group were synthesized and characterized by FTIR, 1H NMR, 13C NMR, mass spectrometry and elemental analysis. In-vitro cytotoxicity of all three complexes was evaluated using COLO 205 (human colon cancer cell line) against the parent drug "oxaliplatin". The compound 4-amino-(transcyclohexane-1,2-diamine) platinum(II) (8) showed potent cytotoxicity with IC50 = 0.12 μM as compared to oxaliplatin (IC50 = 0.19 μM) and its aqueous solubility was found to be 16 mg/mL which is higher than oxaliplatin (8 mg/mL). The acute toxicity showed that the platinum complex (8) was less toxic than oxaliplatin. Molecular oxaliplatin-DNA complex structure indicates that the diaminocyclohexane (DACH) and Pt (II) showed interactions with N7 and O6 of GG base pairs of DNA helix. In this present study, it is interesting to note that all three platinum based anticancer agents with phthalate as the leaving group exhibited great cytotoxicity, less toxicity, good lipophilicity as well as better aqueous solubility. 2013 Bentham Science Publishers.

Vitamin D analogues

The invention concerns novel bi-aromatic compounds having the formula: which are analogs of vitamin D, the process of preparing them, as well as their use in pharmaceutical compositions in human or veterinary medicine, particularly in dermatology, cancer treatment, treatment of auto-immune diseases, and in organ or tissue transplants. Cosmetic compositions and methods of use are also included.

Vitamin D analogues

The invention relates to novel bicyclic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in carcinology and in the field of autoimmune diseases and that of organ or tissue transplants in particular), or alternatively in cosmetic compositions.

Disazo dyestuffs

Disazo dyestuffs have been found which, in the form of the free acid, correspond to the formula (I) STR1 represents H or an optionally substituted aliphatic or aromatic radical and R1 to R6 and A have the meaning given in the description, which are outstandingly suitable for inkjet printing.