5473-12-1

Basic information

• Product Name: sarcosine methyl ester
• Synonyms: sarcosine methyl ester;Glycine, N-Methyl-, Methyl ester
• CAS NO: 5473-12-1
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.12
• Mol File: 5473-12-1.mol

Chemical Properties

• Boiling Point: 118.9 °C at 760 mmHg
• Flash Point: 25.7 °C
• Appearance: /
• Density: 0.964 g/cm³
• Vapor Pressure: 16.3mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 7.44±0.10(Predicted)
• CAS DataBase Reference: sarcosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: sarcosine methyl ester(5473-12-1)
• EPA Substance Registry System: sarcosine methyl ester(5473-12-1)

Safety Data

• Hazardous Substances Data: 5473-12-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Sarcosine methyl ester is used as an Acetyl-CoA Carboxylase (ACC) inhibitor for the treatment of diseases associated with ACC activity. ACC is a key enzyme involved in fatty acid synthesis, and its inhibition can have therapeutic effects on certain conditions.
Used in Chemical Synthesis:
Sarcosine methyl ester is used in the preparation of Spiro compounds, which are complex organic molecules with a spiro structure. These compounds have diverse applications in the pharmaceutical, agrochemical, and materials science industries.
Used in Antimicrobial and Anticancer Applications:
Sarcosine methyl ester is also used in the preparation of Nitroxoline derivatives, which have potential applications in the treatment of infections and cancer. Nitroxoline is a broad-spectrum antimicrobial agent, and its derivatives can be further developed to target specific pathogens or cancer cells.

InChI:InChI=1/C4H9NO2/c1-5-3-4(6)7-2/h5H,3H2,1-2H3/p+1

Upstream product

• 616-34-2 methoxycarbonylmethylamine 
• 56-40-6 glycine 

Downstream Products

• 101721-46-4 (+/-)-3-methyl-2t,5c-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester 
• 101721-46-4 (+/-)-3-methyl-2c,5t-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester 
• 101721-46-4 (+/-)-3-methyl-2t,5t-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester 
• 68259-72-3 [Methyl-(2-oxo-3-phenyl-propionyl)-amino]-acetic acid methyl ester 
• 18030-29-0 [(2-Amino-3,5-dibromo-benzyl)-methyl-amino]-acetic acid 
• 18054-95-0 [(2-Acetylamino-3,5-dibromo-benzyl)-methyl-amino]-acetic acid 
• 18178-37-5 [(2-Acetylamino-6-chloro-benzyl)-methyl-amino]-acetic acid 
• 18053-28-6 [(2-Amino-6-chloro-benzyl)-methyl-amino]-acetic acid 
• 18053-30-0 [(2-Benzoylamino-6-chloro-benzyl)-methyl-amino]-acetic acid 
• 42313-17-7 [(2-Amino-5-chloro-benzyl)-methyl-amino]-acetic acid 
• 42312-65-2 [(2-Acetylamino-5-chloro-benzyl)-methyl-amino]-acetic acid 
• 24600-63-3 [(2-Acetylamino-6-bromo-benzyl)-methyl-amino]-acetic acid 
• 18043-02-2 [(2-Acetylamino-4-bromo-benzyl)-methyl-amino]-acetic acid 
• 18043-05-5 [(2-Acetylamino-5-bromo-benzyl)-methyl-amino]-acetic acid 

Relevant articles and documents

Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester

Abstract: Heating glycine (Gly) and methyl glycinate (GlyOCH3) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180°C for 10 min. The deuterium atom inclusion under these conditions averaged up to 1.8 atoms per molecule for Gly and up to 1.0 atom per molecule for GlyOCH3. The reaction with tritium gas gave labeled products with a specific radioactivity of 27–31 Ci/mmol for Gly and 18 Ci/mmol for GlyOCH3.