54930-24-4

Basic information

• Product Name: N-Glycinylmaleamic acid
• Synonyms: N-Glycinylmaleamic acid;Maleamidoacetic acid;N-(Carboxymethyl)maleamic acid
• CAS NO: 54930-24-4
• Molecular Formula: C₆H₇NO₅
• Molecular Weight: 173.12
• Product Categories: Organic Building Blocks
• Mol File: 54930-24-4.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Density: 1.487
• CAS DataBase Reference: N-Glycinylmaleamic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Glycinylmaleamic acid(54930-24-4)
• EPA Substance Registry System: N-Glycinylmaleamic acid(54930-24-4)

Safety Data

• Hazardous Substances Data: 54930-24-4(Hazardous Substances Data)

Usage

General Description

N-Glycinylmaleamic acid is a chemical compound with a molecular formula C6H7NO4. It is a derivative of maleamic acid and contains a glycine group attached to the maleic acid backbone. N-Glycinylmaleamic acid is a white crystalline solid, and it is used in various applications such as in the synthesis of pharmaceuticals, dyes, and polymers. It has been studied for its potential in drug delivery systems and as a building block for the development of new materials. N-Glycinylmaleamic acid is also known for its ability to form complexes with metal ions, and its properties make it a versatile compound with potential uses in various industries.

Upstream product

• 108-31-6 maleic anhydride 
• 56-40-6 glycine 

Downstream Products

• 14109-64-9 (cis-3-methoxycarbonyl-acryloylamino)-acetic acid methyl ester 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 97242-97-2 N-Carboxymethyl-2-phenylsulfanyl-succinamic acid 
• 25021-08-3 N,N-maleoyl-glycine 
• 921223-74-7 2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-N-methyl-N-phenyl acetamide 
• 164025-07-4 (2,5-dioxo-2,5-dihydro-pyrrol-1-yl)acetic acid methyl ester 
• 110-16-7 maleic acid 
• 56-40-6 glycine 
• 97243-00-0 2-Benzylamino-N-carboxymethyl-succinamic acid 
• 55750-61-3 (2,5-dioxo-2,5-dihydropyrrol-1-yl)acetic acid 2,5-dioxopyrrolidin-1-yl ester 
• 25800-55-9 N²,N⁴-dibenzyl-asparagine 

Relevant articles and documents

Conjugation between maleimide-containing Pt(IV) prodrugs and furan or furan-containing drug delivery vectors via Diels-Alder cycloaddition

Pt(IV) complexes are considered to act as antitumor prodrugs and their in vivo activity can be improved exploiting drug targeting and delivery strategies. With a view to such applications, the maleimide-containing ligand 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetic acid was used to produce the cisplatin-based Pt(IV) complexes (OC-6-44)-diamminedichlorido(ethanolato)(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV) and (OC-6-44)-acetatodiamminedichlorido(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetato)platinum(IV). These complexes underwent Diels-Alder reaction with furan, used as a model molecule to set up the experimental conditions, at ambient temperature up to 50 h, with limited decomposition. Finally, the reaction between the maleimide-containing Pt(IV) complexes and silica nanoparticles decorated with furan were successfully used as a proof-of-concept to demonstrate the clickability of functionalized vectors for drug delivery.

Synthesis and in vitro testing of new potent polyacridine-melittin gene delivery peptides

The combination of a polyacridine peptide modified with a melittin fusogenic peptide results in a potent gene transfer agent. Polyacridine peptides of the general formula (Acr-X)n-Cys were prepared by solid-phase peptide synthesis, where Acr is

Probing structural effects on replication efficiency through comparative analyses of families of potential self-replicators

A formidable synthetic apparatus for the creation of nanoscale molecular structures and supramolecular assemblies through molecular structures can potentially be created from systems that are capable of parallel automultiplication (self-replication). In order to achieve this goal, a detailed understanding of the relationship be tween molecular structure and replication efficiency is necessary. Diastereoisomeric templates that are capable of specific and simultaneous autocatalysis have been synthesised. A systematic experimental and theoretical evaluation of their behaviour and that of structurally-related systems reveals the key determinants that dictate the emergence of self-replicative function and defines the structural space within which this behaviour is observed.