5509-99-9

Basic information

• Product Name: 2-morpholin-4-yl-1-phenyl-2-thioxoethanone
• CAS NO: 5509-99-9
• Molecular Formula: C₁₂H₁₃NO₂S
• Molecular Weight: 235.3021
• Mol File: 5509-99-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 74-75℃
• Boiling Point: 367.2°C at 760 mmHg
• Flash Point: 175.9°C
• Density: 1.257g/cm³
• Vapor Pressure: 1.39E-05mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 2-morpholin-4-yl-1-phenyl-2-thioxoethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-morpholin-4-yl-1-phenyl-2-thioxoethanone(5509-99-9)
• EPA Substance Registry System: 2-morpholin-4-yl-1-phenyl-2-thioxoethanone(5509-99-9)

Safety Data

• Hazardous Substances Data: 5509-99-9(Hazardous Substances Data)

Upstream product

• 949-01-9 1-(morpholin-4-yl)-2-phenylethanethione 
• 110-91-8 morpholine 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 98-86-2 acetophenone 
• 1816-88-2 2-azido-1-phenylethan-1-one 
• 70-11-1 α-bromoacetophenone 
• 1074-12-0 phenylglyoxal hydrate 
• 614-21-1 2-nitroacetophenone 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 100-52-7 benzaldehyde 
• 14677-24-8 3-Morpholinoacrylophenon 
• 2461-80-5 diphenacyl sulfide 
• 779-53-3 4-morpholinylacetophenone 

Downstream Products

• 611-73-4 Benzoylformic acid 
• 143634-16-6 1-Morpholino-2-phenyl-1,2-ethanedithione 
• 40991-78-4 4-(phenylglyoxylyl)morpholine 

Relevant articles and documents

Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions

We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.

Desulfurizing agent for thioamides

Thioamides treated with thionyl chloride in an ionic liquid were successfully converted into amides.

Metal-Free C-N or C-C Bond Cleavages of α-Azido Ketones: An Oxidative-Amidation Strategy for the Synthesis of α-Ketothioamides and Amides

A novel metal-free oxidative-amidation strategy for the synthesis of α-ketothioamides and amides from α-azido ketones was developed. The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then nucleophilically attacked by amines, causing the cleavage of the C-N bond to afford α-ketothioamides, while amides could be formed with the release of nitrogen gas and cyano anion in the presence of PhI(OAc)2 by selective C-C bond cleavage.