55165-09-8Relevant articles and documents
Synthesis of optically active heterocyclic compounds by preparation of 1,3-dinitro derivatives and enzymatic enantioselective desymmetrization of prochiral diamines
Rios-Lombardia, Nicolas,Busto, Eduardo,Gotor-Fernandez, Vicente,Gotor, Vicente
scheme or table, p. 484 - 493 (2010/04/28)
A general approach for the highly efficient chemical preparation of novel optically active 2-substituted propane-1,3-diamines is described. Diamines have been obtained from the corresponding commercially available aldehydes in a straightforward, two-step synthesis via the corresponding 1,3-dinitro compounds, which were hydrogenated under mild reaction conditions by using platinum dioxide as the catalyst. Subsequent enzymatic enantioselective desymmetrization mediated by Pseudomonas cepacia lipase allowed the recovery of a family of monocarbamates in good to high, enantiomeric excesses (70-90% ee).
First desymmetrization of 1,3-propanediamine derivatives in organic solvent. Development of a new route for the preparation of optically active amines
Bustos, Eduardo,Gotor-Fernandez, Vicente,Montejo-Bernardo, Jose,Garcia-Granda, Santiago,Gotor, Vicente
, p. 4203 - 4206 (2008/02/14)
The chemical synthesis and enzymatic desymmetrization of a panel of prochiral diamines have been successfully described for the first time using lipases in organic solvents. A family of 2-aryl-1,3-propanediamines has been obtained with high enantiopurity and good yields in the PSL-catalyzed reaction using diallyl carbonate in 1,4-dioxane.
4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives
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, (2008/06/13)
Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally