55165-09-8

Basic information

• Product Name: 1,3-Propanediamine, 2-phenyl-
• Synonyms: 1,3-Propanediamine, 2-phenyl-;2-phenyl-1,3-Propanediamine
• CAS NO: 55165-09-8
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• Mol File: 55165-09-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Propanediamine, 2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Propanediamine, 2-phenyl-(55165-09-8)
• EPA Substance Registry System: 1,3-Propanediamine, 2-phenyl-(55165-09-8)

Safety Data

• Hazardous Substances Data: 55165-09-8(Hazardous Substances Data)

Usage

Physical State

Colorless to light yellow liquid

Primary Use

Curing agent for epoxy resins

Secondary Uses

a. Production of coatings, adhesives, and plastics
b. Corrosion inhibitor
c. Component in lubricants
d. Raw material for pharmaceuticals and agrochemicals

Industrial Applications

Wide range, including coatings, adhesives, plastics, corrosion inhibition, lubricants, pharmaceuticals, and agrochemicals

Safety Precautions

Handle with caution due to potential harm if ingested, inhaled, or absorbed through the skin

Hazardous Effects

Can cause irritation to the eyes and skin upon contact

Upstream product

• 216586-10-6 3-phenyl-glutaroyl chloride 
• 78533-83-2 3-Phenylpentandiamid 
• 7647-01-0 hydrogenchloride 
• 72976-16-0 3-phenyl-glutaric acid dihydrazide 
• 110-46-3 isopentyl nitrite 
• 957131-04-3 2-phenylpropane-1,3-diazide 
• 1570-95-2 2-phenylpropane-1, 3-diol 
• 64923-68-8 2-phenylpropane-1,3-diyl dimethanesulfonate 
• 1215225-14-1 2-(4-chlorophenyl)propane-1,3-diazide 

Downstream Products

• 78533-62-7 2-ethoxycarbonylamino-5-phenyl-1,4,5,6-tetrahydropyrimidine 
• 78533-56-9 2-<(methoxycarbonyl)amino>-5-phenyl-1,4,5,6-tetrahydropyrimidine 
• 78534-19-7 2-amino-5-phenyl-1,4,5,6-tetrahydropyrimidine hemisulfate 
• 78533-65-0 2-isopropoxycarbonylamino-5-phenyl-1,4,5,6-tetrahydropyrimidine 
• 181304-72-3 N-(2-phenyl-3-aminopropyl)phthalamic acid 
• 957131-05-4 N-(3-amino-2-phenylpropyl)acetamide 
• 873977-00-5 N,N'-(2-phenylpropane-1,3-diyl)diacetamide 
• 957131-07-6 (R)-allyl (3-amino-2-phenylpropyl)carbamate 
• 181304-76-7 [3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-propyl]-carbamic acid ethyl ester 
• 181304-74-5 N-(3-Ethoxycarbonylamino-2-phenyl-propyl)-phthalamic acid 
• 181304-77-8 (4-Chloro-butyl)-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-propyl]-carbamic acid ethyl ester 
• 95724-75-7 2-(methylamino)-5-phenyl-1,4,5,6-tetrahydropyrimidine 
• 437708-57-1 tert-butyl (3-amino-2-phenylpropyl)carbamate 

Relevant articles and documents

Synthesis of optically active heterocyclic compounds by preparation of 1,3-dinitro derivatives and enzymatic enantioselective desymmetrization of prochiral diamines

A general approach for the highly efficient chemical preparation of novel optically active 2-substituted propane-1,3-diamines is described. Diamines have been obtained from the corresponding commercially available aldehydes in a straightforward, two-step synthesis via the corresponding 1,3-dinitro compounds, which were hydrogenated under mild reaction conditions by using platinum dioxide as the catalyst. Subsequent enzymatic enantioselective desymmetrization mediated by Pseudomonas cepacia lipase allowed the recovery of a family of monocarbamates in good to high, enantiomeric excesses (70-90% ee).

Enzymatic desymmetrization of prochiral 2-substituted-1,3-diamines: Preparation of valuable nitrogenated compounds

A wide range of prochiral 1, 3-diamines were first efficiently synthesized and subsequently desymmetrized by using lipase from Pseudomonas cepacia as catalyst and diallyl carbonate as alkoxycarbonylating agent. In all cases, the amino carbamates of R-configuration were recovered. Final selective cleavage of the N-allyloxycarbonyl moiety was carried out under mild reaction conditions, which demonstrates the high versatility and potential of this chemoenzymatic route as a source of intermediates in the synthesis of related optically active nitrogenated derivatives.

First desymmetrization of 1,3-propanediamine derivatives in organic solvent. Development of a new route for the preparation of optically active amines

The chemical synthesis and enzymatic desymmetrization of a panel of prochiral diamines have been successfully described for the first time using lipases in organic solvents. A family of 2-aryl-1,3-propanediamines has been obtained with high enantiopurity and good yields in the PSL-catalyzed reaction using diallyl carbonate in 1,4-dioxane.

Synthesis and Antidepressant Profiles of Phenyl-Substituted 2-Amino- and 2--1,4,5,6-tetrahydropyrimidines

A series of 4(6)- and 5-phenyl-substituted 2-amino- and 2-(alkoxycarbonyl)amino-1,4,5,6-tetrahydropyrimidines 2 were prepared and evaluated for central nervous system (CNS) effects in animal models.Several 5-phenyl-substituted compounds possessed potent

4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives

Certain 1,4,5,6-tetrahydropyrimidine compounds which are substituted with an amino, amido or carbamate at the 2-position, with an optionally substituted phenyl at the 5-position or at the 4-position when there is no alkyl at the 1-position and optionally