55299-57-5Relevant articles and documents
Unexpectedly rigid short peptide foldamers in which NH-π and CH-π interactions are preserved in solution
Nara, Masayuki,Ohwada, Tomohiko,Otani, Yuko,Zhai, Luhan
supporting information, p. 8344 - 8347 (2021/08/25)
NH-π and CH-π interactions, due to their weak character, are not easily identified in solution. We report a group of isolable short peptides with stable folds, in which NH-π and CH-π main chain-side chain interactions can be detected in solution by means
Synthesizing method using serine to prepare Ramipril key intermediate
-
Paragraph 0065; 0066, (2016/10/10)
The invention relates to a synthesizing method using serine to prepare a Ramipril key intermediate. The Ramipril key intermediate is 2-azabicyclo[3.3.0] octane-3-carboxylic acid hydrochloride or benzyl ester hydrochloride. The synthesizing method includes: using the serine as the initial raw material, and sequentially performing esterification, acyl chloride acylation, deacidification, Michael addition, hydrolysis and hydrogenation reduction to obtain the Ramipril key intermediate. The synthesizing method has the advantages that the key intermediate is synthesized by a five-step method, and the synthesizing method is cheap in raw material, environmentally friendly, simple in preparation process, simple to operate, mild in reaction condition, short in reaction cycle, convenient in post-treatment, low in equipment requirement, capable of avoiding heavy metal pollution and the use of expensive catalysts, few in three wastes, high in product yield and purity and suitable for industrial production.
Acetylation under ultrasonic conditions: Convenient preparation of N-acetylamino acids
Veera Reddy,Ravindranath
, p. 257 - 264 (2007/10/02)
An efficient and simple method of preparation of acetylamino acids from amino acids under ultrasonic conditions is described. The reactions proceed without racemization and the yields are almost quantitative.