5533-38-0

Usage

Uses

Used in Chemical Synthesis:
1-METHYL-1H-BENZIMIDAZOLE-2-SULFONIC ACID is used as a reagent for the preparation of bis(Benzimidazol-2-yl)amines. These compounds are essential in the development of various organic materials, pharmaceuticals, and other specialty chemicals due to their unique structural and functional properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-METHYL-1H-BENZIMIDAZOLE-2-SULFONIC ACID is used as a building block for the synthesis of novel drug candidates. The bis(Benzimidazol-2-yl)amines derived from MBS can be utilized in the development of new therapeutic agents, targeting various diseases and medical conditions.
Used in Research and Development:
1-METHYL-1H-BENZIMIDAZOLE-2-SULFONIC ACID is also used in research and development laboratories for the synthesis and characterization of new compounds. Its unique chemical properties make it a valuable tool for exploring new chemical reactions and developing innovative materials with potential applications in various fields.
Used in Material Science:
In the field of material science, 1-METHYL-1H-BENZIMIDAZOLE-2-SULFONIC ACID can be used as a precursor for the development of advanced materials with specific properties, such as high thermal stability, chemical resistance, or unique optical characteristics. These materials can find applications in various industries, including electronics, aerospace, and automotive.

InChI:InChI=1/C8H8N2O3S/c1-10-7-5-3-2-4-6(7)9-8(10)14(11,12)13/h2-5H,1H3,(H,11,12,13)

Upstream product

• 40828-54-4 1H-benzimidazole-2-sulfonic acid 
• 77-78-1 dimethyl sulfate 
• 51-17-2 benzoimidazole 
• 1632-83-3 1-Methylbenzimidazole 
• 134469-07-1 Benzimidazol-2-thiol 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 2360-22-7 1-methyl-1H-benzimidazole-2-thiol 

Downstream Products

• 57262-37-0 (1-methyl-1H-benzoimidazol-2-yl)-(4-phenyl-thiazol-2-yl)-amine 
• 1632-83-3 1-Methylbenzimidazole 
• 2360-22-7 1-methyl-1,3-dihydro-2H-benzimidazole-2-thione 
• 1622-57-7 2-Amino-1-methylbenzimidazole 
• 2219-14-9 1-methyl-N-phenyl-1H-benzo[d]imidazol-2-amine 

Relevant academic research and scientific papers

Reductive dehalogenation and dehalogenative sulfonation of phenols and heteroaromatics with sodium sulfite in an aqueous medium

Prototropic tautomerism was used as a tool for the reductive dehalogenation of (hetero)aryl bromides and iodides, or dehalogenative sulfonation of (hetero)aryl chlorides and fluorides, using sodium sulfite as the sole reagent in an aqueous medium. This protocol does not require a metal or phase transfer catalyst and avoids using organic solvent as the reaction medium. This method is especially suitable for substrates that readily tautomerize (such as 2-or 4-halogenated aminophenols and 4-halogenated resorcinols), for which dehalogenation or sulfonation proceeds under mild reaction conditions (≤60 °C). As sodium sulfite is an inexpensive, safe, and environmentally less hazardous reagent, this method has at least three potential applications: (i) in the deprotection of halogens as protecting groups, using sodium sulfite as a reducing agent; (ii) in the sulfonation of aromatic halides under mild reaction conditions avoiding hazardous and corrosive reagents/solvents; and (iii) in the transformation of toxic halogenated aromatics into less harmful compounds.

Synthesis and antitrichinellosis activity of some bis(benzimidazol-2-yl)amines

Novel bis(benzimidazol-2-yl)amines were synthesized using two methods and studied for antitrichinellosis activity. DFT calculations were performed in order to determine the geometry of molecules. All derivatives of 2-aminobenzimidazole exhibited higher activity in vitro against Trichinella spiralis larvae in regard to the activity of albendazole, moreover compounds 4f-i manifested antitrichinellosis effect, which surpassed five times the activity of albendazole. The in vivo screening of intestinal phase of the T. spiralis revealed 100% effectiveness of compounds 4g-i at oral dosages of 50 and 100 mg/kg mw, while albendazole possesses 100% efficacy only at a dose of 100 mg/kg mw.

Synthesis and some conversions of N-substituted benzimidazole-2-sulfonic acids

A series of N-substituted benzimidazole-2-sulfonic acids was synthesized in good yield by the N-alkylation of benzimidazole-2-sulfonic acids by alkylation with simple and functionalized alkylating agents under mild conditions. The corresponding N-substitu

CONDENSED DERIVATIVES OF BENZAZOLES. 1. SYNTHESIS OF 6- AND 5-SUBSTITUTED BENZIMIDAZOQUINAZOLIN-12-ONES

6(5)H-Benzimidazoquinazolin-12-one was obtained in high yield by condensation of benzimidazole-2-sulfonic acid with anthranilic acid.Methods for the introduction of substituents selectively into the 5 and 6 positions of this heterocycle were develo