55444-93-4

Basic information

• Product Name: 4-FLUORO METHYLPHENOXYACETATE
• Synonyms: 4-FLUORO METHYLPHENOXYACETATE;Aceticacid,(4-fluoropheno;(4-Fluorophenoxy)acetic acid methyl ester
• CAS NO: 55444-93-4
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.1643632
• Mol File: 55444-93-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-FLUORO METHYLPHENOXYACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO METHYLPHENOXYACETATE(55444-93-4)
• EPA Substance Registry System: 4-FLUORO METHYLPHENOXYACETATE(55444-93-4)

Safety Data

• Hazardous Substances Data: 55444-93-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 405-79-8 2-(4-fluorophenoxy)ethanoic acid 
• 371-41-5 4-Fluorophenol 
• 96-32-2 bromoacetic acid methyl ester 
• 96-34-4 methyl chloroacetate 
• 186581-53-3 diazomethane 

Downstream Products

• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 
• 405-79-8 2-(4-fluorophenoxy)ethanoic acid 
• 35370-93-5 2-(4-Fluoro-phenoxy)-thioacetamide 
• 67693-57-6 4-(p-fluorophenoxy)-3-hydroxy-1-butyne 
• 55444-94-5 dimethyl 2-oxo-3-(p-fluorophenoxy)propanephosphonate 
• 738574-70-4 2-(cyclopentylamino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one 
• 449811-73-8 6-(4-fluorophenoxy)-8-methyl-2-methylsulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one 
• 1267156-79-5 C₁₁H₉FN₂O₂ 
• 1448523-93-0 2-(4-fluorophenoxy)-N-[(4-methoxy-2-methylphenylcarbamoyl)methyl]acetamide 
• 1448523-94-1 2-(4-fluorophenoxy)-N-[(4-iodophenylcarbamoyl)methyl]acetamide 
• 1448523-96-3 2-(4-fluorophenoxy)-N-[(4-fluorophenylcarbamoyl)methyl]acetamide 
• 1448523-97-4 N-[(4-bromophenylcarbamoyl)methyl]-2-(4-fluorophenoxy)acetamide 
• 1448523-99-6 2-(4-fluorophenoxy)-N-[(4-methoxyphenylcarbamoyl)methyl]acetamide 
• 1448524-01-3 N-[(cyclohexylcarbamoyl)methyl]-2-(4-fluorophenoxy)acetamide 

Relevant articles and documents

Design, Synthesis, and Biological Profiles of Novel 1,3,4-Oxadiazole-2-carbohydrazides with Molecular Diversity

To unceasingly expand the molecular diversity of 1,3,4-oxadiazole-2-carbohydrazides, herein, small fragments (including -CH2-, -OCH2-, and -SCH2-) were incorporated into the target compounds to screen out the potential succinate dehydrogenase inhibitors (SDHIs). The bioassay results showed that the antifungal effects (expressed by EC50) against Sclerotinia sclerotiorum, Botryosphaeria dothidea, Fusarium oxysporum, and Colletotrichun higginsianum could reach 1.29 (10a), 0.63 (8h), 1.50 (10i), and 2.09 (10i) μg/mL, respectively, which were slightly lower than those of carbendazim (EC50 were 0.69, 0.13, 0.55, and 0.80 μg/mL, respectively). Especially, compound 10h was extremely bioactive against Gibberella zeae (G. z.) with an EC50 value of 0.45 μg/mL. This outcome was better than that of fluopyram (3.76 μg/mL) and was similar to prochloraz (0.47 μg/mL). In vivo trials against the corn scab (infected by G. z.) showed that compound 10h had control activity of 86.8% at 200 μg/mL, which was better than that of boscalid (79.6%). Further investigations found that compound 10h could inhibit the enzymatic activity of SDH in the G. z. strain with an IC50 value of 3.67 μM, indicating that potential SDHIs might be developed. Additionally, the other biological activities of these molecules were screened simultaneously. The anti-oomycete activity toward Phytophthora infestans afforded a minimal EC50 value of 3.22 μg/mL (10h); compound 4d could strongly suppress the growth of bacterial strains Xanthomonas axonopodis pv. citri and Xanthomonas oryzae pv. oryzae with EC50 values of 3.79 and 11.4 μg/mL, respectively; and compound 10a displayed some insecticidal activity toward Plutella xylostella. Given their multipurpose features, these frameworks could be actively studied as potential pesticide leads.

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

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Synthesis and antibacterial evaluation of new sulfone derivatives containing 2-aroxymethyl-1,3,4-oxadiazole/thiadiazole moiety

Sulfones are one of the most important classes of agricultural fungicides. To discover new lead compounds with high antibacterial activity, a series of new sulfone derivatives were designed and synthesized by introducing the aroxymethyl moiety into the scaffold of 1,3,4-oxadiazole/thiadiazole sulfones. Antibacterial activities against three phytopathogens (Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, Xanthomonas axonopodis pv. citri.) were assayed in vitro. As compared to the control of commercial fungicides and some reported sulfone fungicides, seven compounds 5I-1-5I-7 exerted remarkably higher activities with EC50 values ranging from 0.45-1.86 μg/mL against X. oryzae and 1.97-20.15 μg/mL against R. solanacearum. Exhilaratingly, 5I-1, 5I-2 and 5I-4 displayed significant in vivo activity against X. oryzae with protective effect of 90.4%, 77.7%, and 81.1% at 200 μg/mL, respectively, much higher than that exhibited by Bismerthiazol (25.6%) and Thiadiazole-copper (32.0%). And the differential phytotoxicity of active derivatives was preliminarily checked. The results demonstrated that derivative of 2-aroxymethyl-1,3,4-oxadiazole/thiadiazole sulfone can serve as potential alternative bactericides for the management of plant bacterial diseases.

New Approach to 1,4-Benzoxazin-3-ones by Electrochemical C?H Amination

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In silico and pharmacological screenings identify novel serine racemase inhibitors

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Synthesis of (±) travoprost and its analogs

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Method of treating dry eye disorders using 13(S)-HODE and its analogs

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Applicability of Hammett Equation to the Kinetics of Acid-catalysed Esterification of meta- and para-Substituted Phenoxyacetic Acids by Methanol

Rate constants have been determined for the acid-catalysed esterification of meta- and para-substituted phenoxyacetic acids by methanol, with hydrogen chloride as catalyst.The applicability of the Hammett equation to the rate data has been examined.The para-substituted benzoic acids react slower than the corresponding para-substituted phenoxyacetic acids.The probable cause of this behaviour is discussed.

Influence of meta- and para-Substituents on the Kinetics of Esterification of Phenoxyacetic Acids by Methanol

The influence of meta- and para- substituents on the kinetics of acid-catalysed esterification of phenoxyacetic acids is discussed.In the case of para Cl, Br and I substituents, d-orbital resonance is suggested to explain the observed behaviour.The possibility of protonation of the methoxy oxygen in the acid medium employed is indicated to explain the slower rate of reaction of m- and p-methoxyphenoxyacetic acids.