59769-38-9

Upstream product

• 59769-37-8 2-(4-Fluorophenoxy)-acetaldehyde Diethyl Acetal 
• 405-90-3 3-(4-Fluorophenoxy)-1,2-propanediol 
• 55444-93-4 (4-fluorophenoxy)acetic acid methyl ester 
• 371-41-5 4-Fluorophenol 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 108-95-2 phenol 

Downstream Products

• 67693-57-6 4-(p-fluorophenoxy)-3-hydroxy-1-butyne 
• 620973-10-6 1-(4-fluoro-phenoxy)-4-trimethylsilanyl-but-3-yn-2-ol 
• 524714-06-5 (1E,3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene 
• 620973-06-0 (7E,9E,13E)-(5S,6R,15S)-16-(4-Fluoro-phenoxy)-5,6,15-trihydroxy-hexadeca-7,9,13-trien-11-ynoic acid methyl ester 
• 620973-14-0 4-{(4S,5R)-5-[(1E,3E,7E)-(S)-10-(4-Fluoro-phenoxy)-9-hydroxy-deca-1,3,7-trien-5-ynyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-butyric acid methyl ester 
• 62020-11-5 5-(4-fluorophenoxy)-1-penten-4-ol 
• 63247-40-5 1-(2-tetrahydropyranyloxy)-4-hydroxy-5-(4-fluorophenoxy)-2-pentyne 
• 62020-20-6 4-benzyloxy-5-(4-fluorophenoxy)-1-pentene 
• 62020-12-6 4-benzyloxy-5-(4-fluorophenoxy)-1-pentanol 
• 67693-59-8 trans-4-(p-Fluorophenoxy)-1-tributylstannyl-3-trimethylsiloxybut-1-ene 
• 67693-58-7 4-p-fluorophenoxy-3-trimethylsilyloxy-1-butyne 

Relevant academic research and scientific papers

HETEROCYCLIC LIPXON ANALOGS AND USES THEROF

The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.

PHENOXYETHYL PIPERIDINE COMPOUNDS

The present invention provides a compound of the Formula II: Formula II wherein X is: R1 is H, -CN, or F; R2 is H or methyl; R3 is H; and R4 is H, methyl, or ethyl; or R3 and R4 joined toge

Identification of metabolites of the tryptase inhibitor CRA-9249: Observation of a metabolite derived from an unexpected hydroxylation pathway

The metabolites of the tryptase inhibitor CRA-9249 were identified after exposure to liver microsomes. CRA-9249 was found to be degraded rapidly in liver microsomes from rabbit, dog, cynomolgus monkey, and human, and less rapidly in microsomes from rat. T

Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, an analogue of 15R-lipoxin A4

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A4.

NOVEL THIAZOLIDONE-2 DERIVATIVES, 4-DIKETONE SUBSTITUTED, METHOD FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITONS CONTAINING SAME

The present invention relates to the field of chemistry and more particularly to that of therapeutic chemistry. The subject of the present invention is more precisely new 5-phenoxyalkyl-2,4-thiazolidinediones of general formula I: in which A represents a

New non-proteogenic aminoacids bearing an enol aryl-ether moiety

Aminoacids bearing an enol aryl-ether moiety have been synthesized by a new method allowing a great versatility in the introduction of N-protective groups and enol ether functions. This method involves a Wittig-Horner condensation affording alpha, beta-dehydrohomoserine ether derivatives, followed by a regio and stereoselective isomerization into the desired E enol ether. Clean deprotection was achieved providing new 2-amino-4-aryloxybut-3(E)-enoic acids 3.

A New and Efficient Heterogeneous System for the Oxidative Cleavage of 1,2-Diols and the Oxidation of Hydroquinones

Sodium periodate/wet silica gel in the presence of dichloromethane is an efficient reagent for the oxidative cleavage of 1,2-diols and the oxidation of hydroquinones.This easily prepared reagent provides a good alternative of classical metaperiodate oxidation, especially for the preparation of aldehydes, which easily form hydrates.

PROSTANOIDS. V. THE ω-CHAIN FOR 16-ARYLOXYTETRANORPROSTAGLANDINS

During hydrostannylation of 4-aryloxy-3-hydroxy-1-butynes and subsequent cleavage of the obtained E-vinylstannates with iodine the corresponding E-1-iodo-3-hydroxy-4-aryloxy-1-butenes were synthesized.

1-Substituted-1-oxo-prostane-derivatives of the E, A and F series

The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: STR1 wherein R is C1 to C6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR16, SR16, F, or Cl, and R16 is C1 to C6 alkyl.