67693-57-6

Upstream product

• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 
• 693-04-9 butyl magnesium bromide 
• 55444-93-4 (4-fluorophenoxy)acetic acid methyl ester 
• 620973-10-6 1-(4-fluoro-phenoxy)-4-trimethylsilanyl-but-3-yn-2-ol 
• 74-86-2 acetylene 
• 4301-14-8 acetylenemagnesium bromide 
• 405-90-3 3-(4-Fluorophenoxy)-1,2-propanediol 

Downstream Products

• 524714-06-5 (1E,3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene 
• 67693-59-8 trans-4-(p-Fluorophenoxy)-1-tributylstannyl-3-trimethylsiloxybut-1-ene 
• 67693-58-7 4-p-fluorophenoxy-3-trimethylsilyloxy-1-butyne 
• 620973-14-0 4-{(4S,5R)-5-[(1E,3E,7E)-(S)-10-(4-Fluoro-phenoxy)-9-hydroxy-deca-1,3,7-trien-5-ynyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-butyric acid methyl ester 
• 620973-06-0 (7E,9E,13E)-(5S,6R,15S)-16-(4-Fluoro-phenoxy)-5,6,15-trihydroxy-hexadeca-7,9,13-trien-11-ynoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, an analogue of 15R-lipoxin A4

We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11, 13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A4.

PROSTANOIDS. V. THE ω-CHAIN FOR 16-ARYLOXYTETRANORPROSTAGLANDINS

During hydrostannylation of 4-aryloxy-3-hydroxy-1-butynes and subsequent cleavage of the obtained E-vinylstannates with iodine the corresponding E-1-iodo-3-hydroxy-4-aryloxy-1-butenes were synthesized.

1-Substituted-1-oxo-prostane-derivatives of the E, A and F series

The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: STR1 wherein R is C1 to C6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR16, SR16, F, or Cl, and R16 is C1 to C6 alkyl.

11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives

This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

11-(2-Hydroxyethylthio)prostenoic acid E2 series derivatives

This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.