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Cas Database

56038-13-2

56038-13-2

56038-13-2

Identification

  • Product Name:Sucralose

  • CAS Number: 56038-13-2

  • EINECS:259-952-2

  • Molecular Weight:397.637

  • Molecular Formula: C12H19Cl3O8

  • HS Code:2932 14 00

  • Mol File:56038-13-2.mol

Synonyms:Trichlorosucrose;4,1,6-Trichloro-4,1,6-trideoxy-galacto-sucrose;1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactose;1,6-Dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside;See R-D-Galactopyranoside,1,6-dichloro-1,6- dideoxy-a-D-fructofuranosyl 4-chloro-4-deoxy-;Sucralose (Trichlorosucorose);Sucralose Fccv;Sucralose [BAN];(2R,3R,4R,5S,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxy-oxolan-2-yl]oxy-5-chloro-6-(hydroxymethyl)oxane-3,4-diol;

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Chemical Properties

  • Appearance/Colour:Off-White Amorphous Solid

  • Melting Point: 125.5oC

  • Boiling Point: 669.4 °C at 760 mmHg

  • Flash Point:358.7 °C

  • Density: 1.69 g/cm3

  • Solubility:Do you have solubility information on this product that you woul

  • Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere

  • Vapor Pressure: 8.79E-21mmHg at 25°C

  • Refractive Index: 1.604

  • PKA: 12.52±0.70(Predicted)

  • Merck: 14,8880

  • BRN: 3654410

  • PSA: 128.84000

  • LogP: -1.65610

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:No signal word.

  • Hazard Statement:none

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. /SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

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  • Manufacture/Brand:Usbiological
  • Product Description:Sucralose
  • Packaging:100mg
  • Price:$ 403
  • Delivery:In stock
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  • Manufacture/Brand:Usbiological
  • Product Description:Sucralose
  • Packaging:100g
  • Price:$ 337
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  • Manufacture/Brand:TRC
  • Product Description:Sucralose
  • Packaging:10g
  • Price:$ 255
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Sucralose >98.0%(HPLC)
  • Packaging:100g
  • Price:$ 262
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Sucralose >98.0%(HPLC)
  • Packaging:25g
  • Price:$ 86
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Sucralose >98.0%(HPLC)
  • Packaging:5g
  • Price:$ 31
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Sucralose powder EMPROVE?ESSENTIALPhEur,NF,JPE
  • Packaging:10 g
  • Price:$ 51.5
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Sucralose powder EMPROVE? ESSENTIAL Ph Eur,NF,JPE
  • Packaging:1008940010
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Sucralose Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging:500mg
  • Price:$ 72.8
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Sucralose granular EMPROVE?ESSENTIALPhEur,NF,JPE
  • Packaging:10 g
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Relevant articles and documentsAll total 47 Articles be found

Bioconversion of sucralose-6-acetate to sucralose using immobilized microbial cells

Chaubey, Asha,Raina, Chand,Parshad, Rajinder,Rouf, Abdul,Gupta, Pankaj,Taneja, Subhash C.

, p. 81 - 86 (2013)

Bioconversion of sucralose-6-acetate to sucralose, an artificial sweetener has been carried out using Arthrobacter sp. (ABL) and Bacillus subtilis (RRL-1789) strains isolated at IIIM, Jammu, India. Biotransformation of sucralose-6-acetate to sucralose involves use of microbial whole cells, immobilized whole cells and immobilized whole cell bioreactor. Immobilized whole cells packed bed reactor has shown much superior biotransformation process in aqueous system using green technology, where purification of the final product is not required. The final sucralose bioproduct was directly concentrated under vacuum to get white crystalline powder. The immobilized whole cell bioreactor was used for more than three cycles continuously, thus provided much cheaper, less time consuming and easy down streaming process. Moreover, the method does not require any purification steps, which is otherwise requisite for presently available methods for sucralose production, resulting in even lower cost of overall process.

Recrystallization method of sucrose-6-acetate and applications thereof

-

Paragraph 0052; 0053; 0058, (2017/09/01)

The invention discloses a recrystallization method of sucrose-6-acetate, and applications thereof. The recrystallization method comprise following steps: a solvent is added into a sucrose-6-acetate mixture obtained via sucrose esterification; and stirring, dissolving, filtering, and drying are carried out so as to obtain sucrose-6-acetate, wherein the solvent is a mixture of a nitrile solvent and an ether solvent. The recrystallization method is capable of increasing sucrose-6-acetate purity, and reducing adverse influences on subsequent chlorination.

Deacylating method of sucralose-6-acetate

-

Paragraph 0013; 0014, (2016/12/01)

The invention discloses a deacylating method of sucralose-6-acetate, comprising the following steps: adding sucralose-6-acetate into methanol solution of sodium methylate, reacting at 58-62 DEG C for 3-5 hours, vacuum distilling and recycling methanol, and washing obtained solid with ethyl acetate to obtain sucralose. Compared with existing deacylating methods of sucralose-6-acetate, the method of the invention can be used to provide significant deacylating effect, and the yield of sucralose after deacylating is up to higher than 85%.

Process route upstream and downstream products

Process route

sucralose-6-acetate
105066-21-5

sucralose-6-acetate

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With methanol; sodium methylate; at 40 - 50 ℃; for 2h;
95%
With methanol; sodium methylate; at 15 - 20 ℃; for 5h;
86%
4-methyl-morpholine; In ethanol; for 3h; pH=9.5; Product distribution / selectivity; Heating / reflux;
72.4%
triethylamine; In methanol; for 7h; pH=13; Product distribution / selectivity; Heating / reflux;
70.8%
tert-butylamine; In methanol; at 20 ℃; for 5h; pH=12; Product distribution / selectivity;
68%
With methanol; acetyl chloride; at 35 - 40 ℃; for 12 - 16h; pH=3.5 - 4; Product distribution / selectivity; Acetate buffer in methanol;
28%
With sodium hydroxide; water; N,N-dimethylammonium chloride; pH=~ 10.5;
sucralose-6-acetate; With sodium benzoate; sodium hydroxide; In water; N,N-dimethyl-formamide; at 5 - 25 ℃; pH=11.5 - 13.5;
With acetic acid; In water; N,N-dimethyl-formamide; at 0 - 5 ℃; Product distribution / selectivity;
With calcium hydroxide; In water; N,N-dimethyl-formamide; for 8h; pH=9.5; Product distribution / selectivity;
sucralose-6-acetate; With methanol; calcium hydroxide; water; pH=9.5;
With sulfuric acid; water; In methanol;
With calcium hydroxide; water; pH=9.0 - 9.5; Product distribution / selectivity;
sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 33 - 40 ℃; for 4 - 8h; pH=10.5 - 11.2;
With hydrogenchloride; water; In N,N-dimethyl-formamide; for 0.25h; pH=5.53 - 7; Product distribution / selectivity;
sucralose-6-acetate; With magnesium hydroxide; sodium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 3h; pH=8.95 - 10.5;
With carbon dioxide; water; In N,N-dimethyl-formamide; for 1.5h; pH=7.6; Product distribution / selectivity;
sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 4h; pH=10.5;
With carbon dioxide; water; In N,N-dimethyl-formamide; for 0.5h; pH=7.2 - 7.5; Product distribution / selectivity;
sucralose-6-acetate; With sodium hydroxide; water; In N,N-dimethyl-formamide; at 33.0456 ℃; for 8h; pH=11.1; large scale;
With hydrogenchloride; water; In N,N-dimethyl-formamide; for 0.25h; Product distribution / selectivity;
sucralose-6-acetate; With calcium hydroxide; water; In N,N-dimethyl-formamide; at 40 ℃; for 2.5h; pH=10.2;
With carbon dioxide; water; In N,N-dimethyl-formamide; pH=5.8 - 6; Product distribution / selectivity;
In methanol; Product distribution / selectivity;
With sodium methylate; In methanol; at 30 ℃; for 4h;
With sodium hydroxide; In N,N-dimethyl-formamide; at 22 ℃; pH=11.7; Product distribution / selectivity;
sucralose-6-acetate; With water; sodium hydroxide; In N,N-dimethyl-formamide; at 40 ℃; for 4h; pH=10.5;
With hydrogenchloride; water; In N,N-dimethyl-formamide; pH=7; Product distribution / selectivity;
With sodium hydroxide; In water; pH=9.0 - 9.5;
With methanol; ammonia; Industry scale;
With sodium hydroxide; In water; N,N-dimethyl-formamide; at 53 ℃; for 6h; under 40 Torr; pH=12.4;
With methanol; potassium hydroxide; at 45 ℃; for 4h; pH=11;
With sodium hypochlorite; water; In methanol; at 0 - 5 ℃; for 4h; pH=12; Solvent; pH-value;
48 g
With Arthrobacter sp. lipase; In aq. buffer; for 96h; Reagent/catalyst; Enzymatic reaction;
With sodium methylate; In methanol; at 20 ℃; for 4h;
7.9 g
With sodium methylate; In methanol; at 58 - 62 ℃; for 5h; Time;
141 g
With sodium hydroxide; In methanol; at 40 ℃; Temperature; Flow reactor;
pH=9.0 - 9.5; Product distribution / selectivity;
With sodium hydroxide; water; pH=9.0 - 9.5; Product distribution / selectivity;
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside
55832-20-7

2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium hydroxide; water; for 0.25h;
In methanol; water; Product distribution / selectivity;
85%
With methanol; sodium methylate; at 15 - 20 ℃; for 5h;
83%
With methanol; sodium carbonate; at 20 ℃; for 2h;
70%
With tetra(n-butyl)ammonium hydroxide; In methanol; at 20 ℃; pH=9;
68.8%
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 20 - 45 ℃; for 1.5h;
With water; acetic acid; at 20 ℃; pH=7.0;
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; pH=10.5;
In methanol;
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 25 - 30 ℃;
Product distribution / selectivity;
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium methylate; at 10 - 22 ℃; for 0.5 - 4h; pH=8 - 11;
With acetic acid; In methanol; at 22 ℃; Product distribution / selectivity;
2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-galactopyranosyl 3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranoside; With methanol; sodium hydroxide; water; at 22 ℃; for 0.583333 - 0.833333h; pH=8 - 9;
With acetic acid; In methanol; water; at 22 ℃; pH=6.5 - 7; Product distribution / selectivity;
6-O-acetyl sucrose
63648-81-7,936001-72-8

6-O-acetyl sucrose

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With N-chloromethylene-N-phenylethylamine hydrochloride; at 80 - 115 ℃; for 9.5h; Reagent/catalyst; Temperature; Inert atmosphere;
77%
6-O-acetyl sucrose; With (chloromethylene)dimethyliminium chloride; In ISOPROPYLAMIDE; N,N-dimethyl-formamide; at 3 - 105 ℃;
With water; sodium hydroxide; In ISOPROPYLAMIDE; N,N-dimethyl-formamide; at 20 ℃; pH=9.75; Product distribution / selectivity;
70%
With bis(trichloromethyl) carbonate; In N,N-dimethyl-formamide; at -15 - 20 ℃; for 0.5h;
65.6%
6-O-acetyl sucrose; With phosphorus pentachloride; N,N-dimethyl-formamide; at 0 - 115 ℃;
With calcium hydroxide; In water; N,N-dimethyl-formamide; pH=9.5;
With phosphorus pentachloride; N,N-dimethyl-formamide; at 0 - 115 ℃; Industry scale;
40 %Chromat.
3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-glucopyranoside

3,4-di-O-acetyl-1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl 2,3,6-tri-O-acetyl-4-chloro-4-deoxy-α-D-glucopyranoside

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With methanol; sodium methylate; at 20 ℃; for 2h;
93%
6-O-acetyl sucrose
63648-81-7,936001-72-8

6-O-acetyl sucrose

sucralose-6-acetate
105066-21-5

sucralose-6-acetate

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With phosphorus pentachloride; N,N-dimethyl-formamide; at 0 - 115 ℃;
With Vilsmeier reagent; acetic acid; In N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; at 0 - 100 ℃; Overall yield = 68.61 %Chromat.; Inert atmosphere;
6-O-acetyl sucrose
63648-81-7,936001-72-8

6-O-acetyl sucrose

sucralose-6-acetate
105066-21-5

sucralose-6-acetate

3',6'-anhydro-4,1'-dichloro-4,1'-dideoxysucralose

3',6'-anhydro-4,1'-dichloro-4,1'-dideoxysucralose

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With Vilsmeier reagent; acetic acid; In N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; at 15 - 96 ℃; Solvent; Overall yield = 66.85 %Chromat.; Inert atmosphere;
sucrose-6-acetate
63648-78-2

sucrose-6-acetate

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
sucrose-6-acetate; With Vilsmeier reagent; at 85 - 115 ℃; for 6.5h;
With sodium hydroxide; In water; for 4 - 5h; pH=9.0; Product distribution / selectivity;
50%
sucrose 6-acetate persulphite

sucrose 6-acetate persulphite

N-benzyl-N,N,N-triethylammonium chloride
56-37-1

N-benzyl-N,N,N-triethylammonium chloride

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With hydrogenchloride; ammonium hydroxide; thionyl chloride; sodium methylate; acetic anhydride; In pyridine; methanol; 1,1,2-trichloroethane; water;
sucrose-6-acetate
936001-72-8

sucrose-6-acetate

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
With thionyl chloride; ammonia; In pyridine; methanol; 1,2-dichloro-ethane;
6-acetyl sucrose
63648-85-1

6-acetyl sucrose

Sucralose
56038-13-2

Sucralose

Conditions
Conditions Yield
6-acetyl sucrose; With phosphorus pentachloride; N,N-dimethyl-formamide; at 5 - 115 ℃;
With calcium hydroxide; at 22 ℃; for 3h; pH=9.5;
With hydrogenchloride; pH=7.0;

56038-13-2 Upstream products

56038-13-2 Downstream products

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