5619-05-6

Basic information

• Product Name: DL-VALINE METHYL ESTER HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003876;METHYL DL-VALINATE HYDROCHLORIDE;METHYL-2-AMINO-3-METHYL-BUTANOATE HCL;METHYL 2-AMINO-3-METHYLBUTANOATE HYDROCHLORIDE;H-DL-VAL-OME HCL;DL-VALINE METHYL ESTER HYDROCHLORIDE;DL-A-AMINOISOVALERIC ACID METHYL ESTER HYDROCHLORIDE;DL-2-AMINO-3-METHYLBUTANOIC ACID METHYL ESTER HYDROCHLORIDE
• CAS NO: 5619-05-6
• Molecular Formula: C₆H₁₄NO₂*Cl
• Molecular Weight: 167.63
• EINECS: 228-620-9
• Product Categories: Amino Acids Derivatives;Valine [Val, V];Amino Acids and Derivatives;Amino hydrochloride
• Mol File: 5619-05-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 171 °C
• Boiling Point: 145.7 °C at 760 mmHg
• Flash Point: 20.7 °C
• Appearance: /
• Vapor Pressure: 4.8mmHg at 25°C
• Storage Temp.: −20°C
• Water Solubility: Soluble in water
• BRN: 3912090
• CAS DataBase Reference: DL-VALINE METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-VALINE METHYL ESTER HYDROCHLORIDE(5619-05-6)
• EPA Substance Registry System: DL-VALINE METHYL ESTER HYDROCHLORIDE(5619-05-6)

Safety Data

• Safety Statements: 22-24/25
• Hazardous Substances Data: 5619-05-6(Hazardous Substances Data)

Usage

Uses

DL-Valine Methyl Ester is an intermediate used to prepare tetrahydrobenzodiazepinones with anti-HIV activities. It is also used to synthesize [(acylamino)methyl]lambertianic acid derivatives with antitumor activities.

InChI:InChI=1/C6H13NO2.ClH/c1-4(2)5(7)6(8)9-3;/h4-5H,7H2,1-3H3;1H

Upstream product

• 67-56-1 methanol 
• 516-06-3 D,L-valine 
• 112792-74-2 trans-dichlorobis(2-imino-3-methylbutane acid-methylester)palladium 
• 95419-46-8 [PtCl₂(S(CH₃)2)(NH₂CH(COOCH₃)CH(CH₃)2)] 
• 618-36-0 rac-methylbenzylamine 
• 40216-62-4 N-benzyl-L-valine methyl ester 
• 4070-48-8 L-Valine methyl ester 

Downstream Products

• 20613-35-8 DL-2-(2-Benzylthioethylamino)-3-methyl-butanol-⁽¹⁾ 
• 127750-57-6 (R,S)-methyl 3-methyl-2-{[(2E)-3-phenylprop-2-enoyl]amino}butanoate 
• 140151-66-2 methyl N-<<3-<(diethoxyphosphinyl)methyl>phenyl>methyl>-DL-valinate 
• 13803-83-3 methyl 2-(benzylideneamino)-3-methylbutanoate 
• 4840-30-6 Z-Leu-Val-OMe 
• 258850-15-6 (+/-)-methyl 2-[[(5-chloro-2-nitrophenyl)methyl]amino]-3-methylbutanoate 
• 323196-10-7 N-(N-benzyl-N-phenylfluorenyl-(S)-2-amino-4-pentenoyl)-(S)-valine methyl ester 
• 4070-48-8 D-Valine methyl ester 
• 4070-48-8 L-Valine methyl ester 
• 1492-13-3 (2R)-2-(benzoylamino)-3-methylbutyric acid methyl ester 
• 1492-13-3 N-benzoyl-L-valine methyl ester 
• 191274-53-0 (4S)-isopropyl-5,5-diphenyl-oxazolidine-2-thione 
• 14599-03-2 methyl 2-benzamido-3-methylbutanoate 
• 445040-77-7 1-[(4S)-isopropyl-5,5-diphenyl-2-thioxo-oxazolidin-3-yl]-ethanone 

Relevant articles and documents

Ferrocene-modified amino acids: synthesis and in vivo bioeffects on hippocampus

A method for the ferrocene modification of amino acids of natural and synthetic origin has been developed. In the in vivo studies, the hippocampal electrical activity under the action of ferrocenyl(phenylpyrazolyl)glycine (1) was assessed. A meaningful rise (up to 25% compared to the control) in the response amplitudes of the focal potentials of the hippocampal region СА1 after intraperitoneal administration of compound 1 at the dose of 2.0 mg kg–1 was established.

Selective oxidation of amines to aldehydes or imines using laccase-mediated bio-oxidation

An efficient and practical chemo-enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6-tetramethylpiperidine 1-oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio-oxidation of a series of primary, secondary and cyclic amines has been achieved.

Highly tunable arylated cinchona alkaloids as bifunctional catalysts

We report the design and evaluation of a library of chiral bifunctional organocatalysts in which the distance between the catalytically active units can be systematically varied.