56578-36-0

Basic information

• Product Name: 3-Methoxycinnamaldehyde
• Synonyms: 3-Methoxycinnamaldehyde;3-Methoxycinnamic aldehyde;(E)-3-(3-Methoxyphenyl)-2-propenal;(E)-3'-Methoxycinnamaldehyde;(E)-3-(3-Methoxyphenyl)acrylaldehyde
• CAS NO: 56578-36-0
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• Mol File: 56578-36-0.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 296℃
• Flash Point: 138℃
• Appearance: /
• Density: 1.068
• Vapor Pressure: 0.00145mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: 3-Methoxycinnamaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxycinnamaldehyde(56578-36-0)
• EPA Substance Registry System: 3-Methoxycinnamaldehyde(56578-36-0)

Safety Data

• Hazardous Substances Data: 56578-36-0(Hazardous Substances Data)

Usage

General Description

3-Methoxycinnamaldehyde is a natural chemical compound found in certain plant species, including cinnamon and basil, and is commonly used as a flavor and fragrance ingredient. It is also known for its antibacterial and antifungal properties, making it a popular ingredient in cosmetic and personal care products. Additionally, 3-Methoxycinnamaldehyde has potential therapeutic benefits, including anti-inflammatory and anti-cancer properties. The compound has been studied for its potential to be used in developing new drugs for various medical conditions. Overall, 3-Methoxycinnamaldehyde is a versatile compound with various applications in the food, fragrance, and pharmaceutical industries.

InChI:InChI=1/C10H10O2/c1-12-10-6-2-4-9(8-10)5-3-7-11/h2-8H,1H3/b5-3+

Upstream product

• 3054-95-3 acrylaldehyde diethyl acetal 
• 766-85-8 3-methoxy-1-iodobenzene 
• 298-12-4 Glyoxilic acid 
• 863479-52-1 trans-2-(3-methoxyphenyl)vinylboronic acid 
• 52956-26-0 (E)-1-methoxy-3-(prop-1-en-1-yl)benzene 
• 97231-82-8 3,3-Diethoxy-1-(3-methoxy-phenyl)-propan-1-one 
• 15851-92-0 (E)-3-methoxycinnamoyl chloride 
• 33877-04-2 3-methoxycinnamic acid ethyl ester 
• 591-31-1 3-methoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 768-70-7 1-ethynyl-3-methoxybenzene 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 626-20-0 3-methoxystyrene 
• 75-27-4 bromodichloromethane 

Downstream Products

• 1159012-15-3 5-methoxy-3-(3-methoxybenzyl)-7-methyl-2H-chromen-2-one 
• 1181810-18-3 (4S)-4-(3-methoxyphenyl)-3,4-dihydro-2H-benzo[h]chromen-2-ol 
• 1275614-13-5 [Ni(CO₂CHCHC₆H₅CH₂CH₂OHNCC₆H₄OCH₃C₆H₄NCOCH₂C₅H₁₀N)] 
• 1292323-46-6 (E)-tert-butyl 2-(3-(3-methoxyphenyl)allylamino)ethylcarbamate 
• 1292323-88-6 tert-butyl 2-(7-acetyl-9-(3-methoxyphenyl)-3-oxo-1H-pyrrolo[3,4-β]indolizin-2(3H)-yl)ethylcarbamate 
• 1310087-03-6 C₂₁H₁₉NO₃ 
• 1310087-15-0 C₃₄H₃₁N₃O₂ 
• 1612860-88-4 1-(3-hydroxyphenyl)-7-(3-methoxyphenyl)-1,4,6-heptatrien-3-one 

Relevant articles and documents

Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents

Ferroptosis is a regulated and iron-dependent cell death. Ferroptosis inhibitors are promising for treating many neurological diseases. Herein, with phenotypic assays, we discovered a new diphenylbutene derivative ferroptosis inhibitor, DPT. Based on this hit, we synthesized fourteen new diphenylbutene derivatives, evaluated their ferroptosis inhibitory activities in HT22 mouse hippocampal neuronal cells, and found that three compounds exhibited improved inhibitory activities compared with DPT. Among these active compounds, compound 3f displayed the most potent anti-ferroptosis activity (EC50 = 1.7 μM). Further studies demonstrated that 3f is a specific ferroptosis inhibitor. And we revealed that different from the classic ferroptosis inhibitors, 3f blocked ferroptosis by increasing FSP1 protein level. Moreover, 3f can penetrate blood-brain barrier (BBB). In a rat model of ischemic stroke, 3f effectively mitigated cerebral ischemic injury. Therefore, we are confirmed that 3f, as a novel ferroptosis inhibitor with a new scaffold, is promising for further development as an agent against neurological diseases.

Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction

Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is an intramolecular aldol reaction. The enantiomerically pure catalyst is involved in both reactions.

Regioselective Silylations of Propargyl and Allyl Pivalates through Ca-Promoted Reductive C(sp3)-O Bond Cleavage

A practical protocol for the regioselective preparation of 3-phenylpropargylsilanes and 3-phenylallylsilanes in yields of 36-77 and 48-86%, respectively, from readily accessible 3-phenylpropargyl and 1-phenylallyl pivalates was developed through reductive C(sp3)-O bond cleavage. This method represents the first example of the direct application of vastly abundant calcium granules to a reductive coupling reaction. A broad range of propargylsilanes and allylsilanes are simply prepared using easy-to-handle pivalates and chlorotrimethylsilane under mild catalyst-free and additive-free conditions.