5763-44-0Relevant articles and documents
Synthesis process of N-amino-3-azabicyclo [3, 3, 0] octane hydrochloride
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Paragraph 0017; 0027-0028; 0032-0033; 0037-0038; 0042-0043, (2021/05/29)
The invention provides a synthesis process of N-amino-3-azabicyclo [3, 3, 0] octane hydrochloride, and relates to the technical field of gliclazide intermediate synthesis. The synthesis process comprises the following steps: heating, dehydrating and cyclizing 2-carbamoyl amine cyclopentanecarboxylate serving as a raw material under the catalysis of an acid catalyst until no water is generated, adding toluene, refluxing and dissolving, and carrying out post-treatment to obtain 1, 2-cyclopentane dicarboximide; reacting the 1, 2-cyclopentane dicarboximide with chloramine under an alkaline condition, and carrying out post-treatment to obtain N-amino-1, 2-cyclopentane dicarboximide; and reducing the amino-1, 2-cyclopentane dicarboximide in the presence of sodium borohydride/aluminum trichloride and an organic solvent, and performing post-treatment to obtain the product. According to the present invention, the three-step synthesis is performed through the catalytic cyclization reaction, the nucleophilic substitution reaction and the reduction reaction, the raw materials are cheap and easily available, the high toxicity product is not generated, the harsh reaction condition is not required, the yield and the purity of each step are high, and the method is suitable for the large-scale industrial production.
Synthetic method of medical intermediate 1,2-cyclopentane dicarboximide
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Paragraph 0014; 0024-0048, (2021/04/10)
The invention provides a synthetic method of a medical intermediate 1,2-cyclopentane dicarboximide, and relates to the technical field of synthesis of medical intermediates. According to the synthetic method of the 1,2-cyclopentane dicarboximide, 2-carbamyl cyclopentane-1-carboxylic acid is added as a catalyst, a small amount of phenyl ether is added as a heat transfer medium, 2-carbamyl cyclopentane-1-carboxylic acid can have side reaction with a small amount of 1,2-cyclopentane dicarboximide, carboxylic acid groups and amino groups carry out a condensation reaction to generate byproducts, and meanwhile a small amount of water is generated; water reacts with ammonia gas generated in the main reaction to generate ammonia water, thus the conversion rate of the main reaction is improved, and the generation of main products is promoted. Phenylate is used as a high-boiling stable solvent, so that a good heat transfer medium effect is achieved, the dispersion of raw materials, catalysts and products and the release of ammonia gas are promoted, the forward proceeding of the reaction is promoted, the cyclization reaction rate is increased, after post-treatment, a 1,2-cyclopentane dicarboximide pure product with high purity is obtained, and the yield is high.
Synthesis method of cyclopentane-1,2-dicarboximide
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Paragraph 0030-0039, (2018/10/19)
The invention discloses a synthesis method of cyclopentane-1,2-dicarboximide. The synthesis method comprises the following steps: performing dehydration on cyclohexanone and urea as raw materials under the actions of a polymerization inhibitor and a water-carrying agent, heating, dropwise adding an acid liquor for hydrolyzing, adding an alcoholic solvent in the hydrolyzed solution, crystallizing,centrifuging, and drying to obtain cyclohexane-2-carboxamide, dissolving cyclohexane-2-carboxamide in halogenated hydrocarbon, performing halogenation under a halogenation reagent, performing cooling,crystallizing, hydrolyzing, centrifuging and drying to obtain a halide, dispersing the halide in an ammoniating solution for Favorskii rearrangement, sequentially performing cooling, crystallizing, centrifuging, washing and drying to obtain a rearrangement object, namely cyclopentane-1,2-carboxamide, finally adding a proper amount of catalysts, and after high temperature cyclization, performing reduced pressure distillation, performing refined crystallization, centrifuging, and drying, thereby obtaining cyclopentane-1,2-dicarboximide. The synthesis method has the advantages that the reactionstep is shortened, the environmental protection is benefited, the production cost is reduced, and the synthesis method is suitable for large-scale mass production.
Method for synthesizing cyclopentyl imide
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Paragraph 0016; 0017; 0018; 0019; 0020, (2017/07/19)
The invention relates to a method for synthesizing cyclopentyl imide. The method comprises the following steps: reacting a raw material 1,2-cyclopentanediamide with an alkali liquid to generate 1,2-cyclopentanediacid, and reacting the 1,2-cyclopentanediacid with methanamide to generate the cyclopentyl imide. The synthesis method greatly reduces the cyclopentyl imide synthesis temperature to make the reaction mildly proceed, so the high temperature problem in the prior art is solved, the safety in the production process is improved, and energy saving and consumption reduction are realized; and the method has the advantages of liquid and homogenous synthesis system, stable reaction and quality, low temperature reaction conditions, no generation of coking, oxidation or carbonizing waste resides or other impurities, improvement of the quality of the above product, realization of the continuous primary yield reaching 90% or above and being about 10-30% higher than that of present technologies, stable reaction technology conditions, easiness in control, and high reaction conversion rate.
SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
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Page/Page column 4, (2013/02/27)
Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.
