58186-28-0Relevant articles and documents
Synthetic route discovery and introductory optimization of a novel process to idebenone
Tsoukala, Anna,Bjorsvik, Hans-Rene
, p. 673 - 680 (2011/12/01)
An environmentally benign, convenient, high yielding, and cost-effective synthesis leading to idebenone is disclosed. The synthesis includes a bromination process for the preparation of 2-bromo-3,4,5-trimethoxy-1- methylbenzene, a protocol for the Heck cross-coupling reaction using either thermal or microwave heating, olefin reduction by palladium catalyzed hydrogenation, and a green oxidation protocol with hydrogen peroxide as oxidant to achieve the benzoquinone framework. The total synthesis is composed of six steps that provide an overall yield of 20% that corresponds to a step yield of 76%.
Hydroquinone derivatives and intermediates for production thereof
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, (2008/06/13)
There are disclosed novel hydroquinone derivatives of the formulas: STR1 The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments, and the derivatives of the formula (II) are intermediates for the production thereof.
A facile synthesis of 1,4-benzoquinones having a hydroxyalkyl side chain
Goto,Okamoto,Okutani,Imada
, p. 4422 - 4431 (2007/10/02)
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