5892-54-6

Basic information

• Product Name: Dimethylcrocetin
• Synonyms: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid dimethyl ester;Dimethylcrocetin
• CAS NO: 5892-54-6
• Molecular Formula: C₂₂H₂₈O₄
• Molecular Weight: 356.45532
• Mol File: 5892-54-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Dimethylcrocetin(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethylcrocetin(5892-54-6)
• EPA Substance Registry System: Dimethylcrocetin(5892-54-6)

Safety Data

• Hazardous Substances Data: 5892-54-6(Hazardous Substances Data)

Usage

General Description

Dimethylcrocetin is a chemical compound that is found in the spice saffron. It is a derivative of the carotenoid crocin and is responsible for the characteristic color and aroma of saffron. Dimethylcrocetin has been studied for its potential health benefits, including its antioxidant and anti-inflammatory properties. It has also shown potential in promoting cognitive function and mental health. Additionally, it has been studied for its potential role in cancer prevention and treatment. Overall, dimethylcrocetin is a compound with diverse potential health benefits and is of interest for further research and development.

Upstream product

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Downstream Products

• 64603-92-5 sodium (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate 
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Relevant articles and documents

Neocrocin A: A novel crocetin glycoside with a unique system for binding sugars isolated from gardenia yellow

A novel crocetin glycosyl ester, neocrocin A (2), was isolated from gardenia yellow. The structure of 2 was elucidated as that of an all-trans-crocetin β-D-gentiobiosyl β-D-glucopyranosyl-(1→6)-D-2- deoxy-glucopyranos-2-yl diester based on chemical and spectral data. The findings provide evidence that the binding system of crocetin glycosides is not limited to the anomeric position.

Crocetin diester compound as well as preparation method and application thereof

The invention belongs to the technical field of pesticides, and provides a crocetin diester compound as well as preparation and application thereof in plant protection. It is found for the first timethat natural products crocin-1 and crocin-2 show higher anti-plant virus activity level than commercial variety virazole, can be used as a novel botanical pesticide or used as a lead compound for development, and used as the lead to design and synthesize the crocetin diester compound. An anti-plant virus activity test shows that all the compounds show activity on tobacco mosaic viruses, and particularly, the activity level of the crocetin di (4-fluorophenyl ethyl) ester is higher than that of a lead compound.

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 μM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114.0 ± 8.0 and 113.0 ± 11.1 μM, respectively). The results described in this article suggest that saffron may be a helpful alimentary component in the prevention of cancer that potentially contributes to the efficacy of approved cancer therapies.