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BOC-GLU(OBZL)-OME, also known as tert-butyl (2-(((benzyloxy)carbonyl)amino)-3-(benzyloxy)propanoate, is a chemical compound utilized in the realm of organic chemistry. It is characterized by its molecular formula C22H29NO6, which indicates the presence of 22 carbon atoms, 29 hydrogen atoms, 1 nitrogen atom, and 6 oxygen atoms. BOC-GLU(OBZL)-OME's name is derived from its constituent groups: BOC for the tert-butoxycarbonyl protecting group, GLU for the glutamic acid residue, OBZL for the benzyl ester protecting group, and OME for the methoxy group. These groups are strategically incorporated to facilitate specific reactions while shielding other parts of the molecule from unwanted reactions.

59279-58-2

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59279-58-2 Usage

Uses

Used in Organic Chemistry:
BOC-GLU(OBZL)-OME is used as a reagent in the synthesis of peptides, where its protecting groups play a crucial role in controlling the reactivity of the molecule during the assembly process.
Used in Pharmaceutical Industry:
BOC-GLU(OBZL)-OME is used as a building block for the development of new pharmaceutical compounds, particularly in the synthesis of complex peptide-based drugs. Its protecting groups ensure that the molecule can be selectively modified and assembled into the desired drug structure without interference from other reactive sites.
Used in Research and Development:
BOC-GLU(OBZL)-OME is employed as a research tool in academic and industrial laboratories, where it is used to study the synthesis and properties of peptides and other biomolecules. Its unique structure and protecting groups make it an interesting subject for exploration in the field of organic chemistry and biochemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 59279-58-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,2,7 and 9 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 59279-58:
(7*5)+(6*9)+(5*2)+(4*7)+(3*9)+(2*5)+(1*8)=172
172 % 10 = 2
So 59279-58-2 is a valid CAS Registry Number.

59279-58-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-O-benzyl 1-O-methyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate

1.2 Other means of identification

Product number -
Other names (2S)-2-tert-butoxycarbonylaminopentanedioic acid 5-benzyl ester 1-methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59279-58-2 SDS

59279-58-2Relevant articles and documents

An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity

Ieda, Naoya,Itoh, Kaoru,Inoue, Yasumichi,Izumiya, Yusuke,Kawaguchi, Mitusyasu,Miyata, Naoki,Nakagawa, Hidehiko

, p. 353 - 356 (2019)

Pin1 (protein interacting with never in mitosis A-1) is a member of the peptidyl prolyl isomerase (PPIase) family, and catalyzes cis-trans isomerization of pThr/Ser-Pro amide bonds. Because Pin1 is overexpressed in various cancer cell lines and promotes c

Visible-Light Photoredox Synthesis of Chiral α-Selenoamino Acids

Jiang, Min,Yang, Haijun,Fu, Hua

, p. 1968 - 1971 (2016)

N-Acetoxyphthalimide derivatives of two genetically coded proteinogenic amino acids, l-aspartic acid and glutamic acid, were used as visible light photoredox chiral sources and radical precursors, diorganyl diselenides were used as the radical acceptors,

Synthesis of l -Kynurenine and Homo- l -Kynurenine via an Aza-Fries Rearrangement

Bonilla-Reyes, Edgar,Sánchez-Carrillo, Adrian,Vázquez, Alfredo

, p. 3473 - 3479 (2020/09/15)

l -Kynurenine, a non-proteinogenic amino acid, is the primary metabolite of tryptophan via the kynurenine pathway. Kynurenine is involved in a variety of biological processes occurring in the human body, notably in the central nervous system. Thus, the st

Dearomatization of 3-Nitroindoles with Highly γ-Functionalized Allenoates in Formal (3+2) Cycloadditions

Birbaum, Léo,Gillard, Laurent,Gérard, Hélène,Oulyadi, Hassan,Vincent, Guillaume,Moreau, Xavier,De Paolis, Michael,Chataigner, Isabelle

supporting information, p. 13688 - 13693 (2019/11/03)

3-Nitroindoles are easily reacted with highly substituted γ-allenoates in the presence of a commercially available phosphine catalyst. For instance, allenoates derived from biomolecules such as amino and deoxycholic acids are combined for the first time w

Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease

Damalanka, Vishnu C.,Kim, Yunjeong,Alliston, Kevin R.,Weerawarna, Pathum M.,Galasiti Kankanamalage, Anushka C.,Lushington, Gerald H.,Mehzabeen, Nurjahan,Battaile, Kevin P.,Lovell, Scott,Chang, Kyeong-Ok,Groutas, William C.

, p. 1899 - 1913 (2016/03/22)

Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. Norovirus 3CL protease plays a vital role in viral replication by generating structural and nonstructural proteins via the cleavage of the viral polyprotein. Thus, molecules that inhibit the viral protease may have potential therapeutic value. We describe herein the structure-based design, synthesis, and in vitro and cell-based evaluation of the first class of oxadiazole-based, permeable macrocyclic inhibitors of norovirus 3CL protease.

Synthesis of rhodotorulic acid and its 1,4-dimethylated derivative

Nakao, Michiyasu,Fukayama, Shintaro,Kitaike, Syuji,Sano, Shigeki

, p. 1309 - 1316 (2015/03/04)

Facile syntheses of rhodotorulic acid, isolated from Rhodotorula pilimanae as a siderophore, and its 1,4-dimethylated derivative have been achieved by microwave-assisted cyclization of the corresponding dipeptide precursors.

Synthesis of triazole cages containing C3-symmetric α-cyclic tripeptide scaffold

Chakraborty, Subrata,Tai, Dar-Fu

supporting information, p. 2274 - 2276 (2014/04/17)

Two water-soluble C3-symmetric 1,2,3-triazole cages containing α-cyclic tripeptide were efficiently synthesized. The key steps include a click reaction to incorporate l-glutamic or l-aspartic acids to a tripodal linker and a unique one-pot cyclotrimerization.

BORON CONTAINING POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTICS USES THEREOF

-

Page/Page column 39, (2012/08/28)

Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and theft methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent

PYRIDINE DERIVATIVES SUBSTITUTED WITH HETEROCYCLIC RING AND gamma-GLUTAMYLAMINO GROUP, AND ANTIFUNGAL AGENTS CONTAINING SAME

-

Page/Page column 32, (2010/05/13)

The present invention provides an antifungal agent which has excellent antifungal action, and which is also excellent in terms of its properties, and in particular its solubility in water and safety. The present invention discloses a compound represented

POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF

-

Page/Page column 41-42, (2009/01/24)

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.

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