59623-12-0

Basic information

• Product Name: 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE
• Synonyms: 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE;3-(4-METHOXYPHENYL)PROPYL CHLORIDE;3(P-METHOXYPHENYL)PROPYL CHLORIDE;3-(p-Methoxyphenyl)-1-chloropropane
• CAS NO: 59623-12-0
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.66
• Mol File: 59623-12-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 100°C/ .3mm
• Flash Point: 119.6 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.0126mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE(59623-12-0)
• EPA Substance Registry System: 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE(59623-12-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 59623-12-0(Hazardous Substances Data)

Usage

General Description

3-(4'-Methoxyphenyl)propyl chloride, also known as p-methoxyphenylpropyl chloride, is a chemical compound that is commonly used in organic synthesis. It is formed by the reaction of 4’-methoxyacetophenone with propionic acid and thionyl chloride. 3-(4'-METHOXYPHENYL)PROPYL CHLORIDE is used as an intermediate in the production of pharmaceuticals and agricultural chemicals. It is also used in the synthesis of other organic compounds, such as potential drug candidates and materials for industrial use. 3-(4'-Methoxyphenyl)propyl chloride is a versatile chemical with various applications in the field of organic chemistry.

InChI:InChI=1/C10H13ClO/c1-12-10-6-4-9(5-7-10)3-2-8-11/h4-7H,2-3,8H2,1H3

Upstream product

• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 84648-36-2 C₁₈H₁₇ClO₅ 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 24393-56-4 ethyl p-methoxycinnamate 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 501-36-0 (E)-5-[2-4-(hydroxyphenyl)ethenyl]-1,3-benzenediol 
• 115878-50-7 1-chloro-3-(4-methoxyphenyl)propyl phenyl sulfoxide 

Downstream Products

• 134266-13-0 10-[3-(4-Methoxy-phenyl)-propyl]-2-trifluoromethyl-10H-phenothiazine 
• 10415-00-6 [2-(2-Methoxy-phenoxy)-ethyl]-[3-(4-methoxy-phenyl)-propyl]-amine 
• 83986-67-8 1-(methylamino)-3-(p-methoxyphenyl)propane 
• 855909-14-7 2-[3-(4-methoxy-phenyl)-propyl]-adipic acid 
• 1026405-82-2 furan-2-carboxylic acid {4-imino-1-[3-(4-methoxy-phenyl)-propyl]-1,4-dihydro-pyrazolo[3,4-d]pyrimidin-5-yl}-amide 
• 316173-63-4 5-amino-1-[3-(4-methoxy)phenylpropyl]-4-[3-(2-furyl)-1,2,4-triazol-5-yl]pyrazole 
• 316173-62-3 7-[3-(3,4-dimethoxy)-phenylpropyl]-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine 
• 316173-58-7 3-(4-methoxyphenyl)propyl hydrazine hydrochloride 
• 134266-16-3 5-[3-(4-Methoxy-phenyl)-propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine 
• 134266-07-2 10-[3-(4-Methoxy-phenyl)-propyl]-10H-phenothiazine 
• 859316-30-6 1-[3-(4-methoxy-phenyl)-propyl]-2-oxo-cyclopentanecarboxylic acid ethyl ester 

Relevant articles and documents

Site-Selective Alkoxylation of Benzylic C?H Bonds by Photoredox Catalysis

Methods that enable the direct C?H alkoxylation of complex organic molecules are significantly underdeveloped, particularly in comparison to analogous strategies for C?N and C?C bond formation. In particular, almost all methods for the incorporation of alcohols by C?H oxidation require the use of the alcohol component as a solvent or co-solvent. This condition limits the practical scope of these reactions to simple, inexpensive alcohols. Reported here is a photocatalytic protocol for the functionalization of benzylic C?H bonds with a wide range of oxygen nucleophiles. This strategy merges the photoredox activation of arenes with copper(II)-mediated oxidation of the resulting benzylic radicals, which enables the introduction of benzylic C?O bonds with high site selectivity, chemoselectivity, and functional-group tolerance using only two equivalents of the alcohol coupling partner. This method enables the late-stage introduction of complex alkoxy groups into bioactive molecules, providing a practical new tool with potential applications in synthesis and medicinal chemistry.

Trichloroisocynuric acid/DMF as efficient reagent for chlorodehydration of alcohols under conventional and ultrasonic conditions

A new and efficient method for the chlorodehydration of alcohols utilizing TCCA/DMF is described. Various alcohols can be converted smoothly into their corresponding alkyl chlorides in high yields under mild conditions with short reaction times. Taylor & Francis Group, LLC.

Generation of magnesium carbenoids from 1-chloroalkyl phenyl sulfoxides with a Grignard reagent and applications to alkylation and olefin synthesis

Treatment of 1-chloroalkyl phenyl sulfoxides with a Grignard reagent at low temperature gave magnesium carbenoids in quantitative yields. The generated magnesium carbenoids were found to be stable at lower than -60°C for long periods of time and are reactive with Grignard reagents to give alkylated products. The reaction of the generated magnesium carbenoids with various kinds of lithium α-sulfonyl carbanions gave olefins with carbon-carbon bond-formation in good to high yields. This method offers a good way for the preparation of olefins. The scope and limitations of the above-mentioned reactions are described.