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2-chloro-3-nitro-phenol, a chlorinated nitrophenol with the molecular formula C6H4ClNO3, is a pale yellow solid known for its use as an intermediate in the synthesis of pharmaceuticals, dyes, and pesticides. Recognized for its potential toxicity and environmental persistence, it requires careful handling and disposal to mitigate risks to human health and the ecosystem.

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  • 603-84-9 Structure
  • Basic information

    1. Product Name: 2-chloro-3-nitro-phenol
    2. Synonyms: 2-chloro-3-nitro-phenol;Phenol, 2-chloro-3-nitro-;2-Chlor-3-nitro-1-hydroxy-benzol;3-hydroxy-2-chloronitrobenzene;2-Chlor-3-nitrophenol
    3. CAS NO:603-84-9
    4. Molecular Formula: C6H4ClNO3
    5. Molecular Weight: 173.55
    6. EINECS: N/A
    7. Product Categories: API intermediates;Chlorine Compounds;Nitro Compounds
    8. Mol File: 603-84-9.mol
  • Chemical Properties

    1. Melting Point: 120.5 °C
    2. Boiling Point: 279.6 °C at 760 mmHg
    3. Flash Point: 122.9 °C
    4. Appearance: Orange crystalline powder
    5. Density: 1.554 g/cm3
    6. Vapor Pressure: 0.002mmHg at 25°C
    7. Refractive Index: 1.627
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 7.39±0.25(Predicted)
    11. CAS DataBase Reference: 2-chloro-3-nitro-phenol(CAS DataBase Reference)
    12. NIST Chemistry Reference: 2-chloro-3-nitro-phenol(603-84-9)
    13. EPA Substance Registry System: 2-chloro-3-nitro-phenol(603-84-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 603-84-9(Hazardous Substances Data)

603-84-9 Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-3-nitro-phenol is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutic agents.
Used in Dye Industry:
In the dye industry, 2-chloro-3-nitro-phenol serves as a precursor in the production of dyes, enabling the creation of a wide range of colorants for different applications.
Used in Pesticide Industry:
2-chloro-3-nitro-phenol is utilized as an intermediate in the manufacturing process of certain pesticides, playing a role in the development of agricultural chemicals aimed at controlling pests and diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 603-84-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 3 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 603-84:
(5*6)+(4*0)+(3*3)+(2*8)+(1*4)=59
59 % 10 = 9
So 603-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClNO3/c7-6-4(8(10)11)2-1-3-5(6)9/h1-3,9H

603-84-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Chloro-3-Nitro-Phenol

1.2 Other means of identification

Product number -
Other names 2-chloro-3-nitro-phenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:603-84-9 SDS

603-84-9Relevant articles and documents

TRPV4 ANTAGONISTS

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Page/Page column 45-46, (2011/10/13)

The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.

DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS

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Page/Page column 103, (2010/11/17)

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein: A represents an aryl, heteroaryl or heterocyclyl group; and any ring or ring system of said aryl or heteroaryl is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6 alkyl, -CF3, - OCF3, cyano, C1-6 alkoxy, -NR10R11, -X-aryl, -X-heteroaryl and -X-heterocyclyl; R1, R2, R3, R4 and R5 independently represent hydrogen, fluorine, chlorine, -CF3, cyano or C1-6 alkyl, such that at least one of R1, R2, R3, R4 and R5 is other than hydrogen; R6, R7, R8, R9, R10 and R11 independently represent hydrogen or C1-6 alkyl; X represents a linker selected from a bond, -(CH2)n- and -O-(CH2)n-; and n represents an integer from 1 to 3. The compounds or salts modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor ("P2X7 receptor antagonists").

HEPATITIS C INHIBITOR DIPEPTIDE ANALOGS

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Page/Page column 63, (2008/06/13)

The present invention relates to compounds of formula (I): wherein R1, R2, R4, n and m are as defined herein and R3 is selected from: (i) -C(O)OR31 wherein R31 is (C1-6)alkyl or aryl, wherein the (C1-6)alkyl is optionally substituted with one to three halogen substituents; (ii) -C(O)NR32R33, wherein R32 and R33 are each independently selected form H, (C1-6)alkyl, and Het; (iii) -SOvR34, wherein v is 1 or 2 and R34 is selected from: (C1-6)alkyl, aryl, Het, and NR32R33 wherein R32 and R33 are as defined above; and (iv) -CO(O)-R35, wherein R35 is selected from (C1-8)alkyl, (C3-7)cycloalkyl-(C1-4)alkyl, aryl, aryl-(C1-6)alkyl, Het and Het-(C1-6)alkyl, each of which are optionally substituted with one or more substituents each independently selected from halo, (C1-6)alkyl, (C3-7)cycloalkyl, aryl, Het, hydroxyl, -O-(C1-6)alkyl, -S-(C1-6)alkyl, -SO-(C1-6)alkyl, -SO2-(C1-6)alkyl, -O-aryl, -S-aryl, -SO-aryl and -SO2-aryl, wherein the aryl portion of the -O-aryl, -S-aryl, -SO-aryl and -SO2-aryl are each optionally substituted with one to five halo substituents. The present invention further relates to pharmaceutical compositions containing the compounds of formula (I) and methods for using these analogs in the treatment of HCV infection.

HEPATITIS C INHIBITOR PEPTIDE ANALOGS

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Page/Page column 77, (2010/02/15)

The invention relates to compounds of formula (I) wherein R', R2, R3, R4, R5, R6, Y, n and m are as defined herein. The compounds are useful for the treatment and prevention of hepatitis C viral infections in mammals by inhibiting HCV NS3 protease. The invention further relates to azalactone compounds of the formula (III) which can be reacted with an amide anion to produce the compounds of formula (I).

Hepatitis C inhibitor peptide analogs

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Page/Page column 25, (2010/02/15)

Compounds of formula (I): wherein R1, R2, R3, R4, R5, Y, n and m are as defined herein. The compounds are useful as inhibitors of HCV NS3 protease.

NOVEL CANNABINOID CB2 RECEPTOR AGONISTS AND USES THEREOF

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Page/Page column 68-69, (2010/02/11)

Novel selective cannabinoid CB2 receptor ligands, primarily agonists, have a number of biological and pharmacological activities, including bronchial action, immunomodulatory action and analgesia. Hence, they are useful for treating diseases or

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

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Page 86-87, (2010/02/06)

Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, X, Y, and n are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

HEPATITIS C INHIBITOR COMPOUNDS

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Page 42-43, (2008/06/13)

Compounds of formula (I): wherein B, X, R3, L0, L1, L2, R2, R1 and RC are defined herein. The compounds are useful as inhibitors of HCV NS3 protease for the treatment of hepatitis C viral infection.

Method for producing an optically active 1-substituted 2-propanol

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, (2008/06/13)

A method for producing an optically active 1-substituted 2-propanol of the following formula 1, which comprises reacting a hydroxy aromatic compound of the following formula 2 with an optically active propylene oxide in the presence of a catalyst:AOH??Formula 2CH3C*H(OH)CH2OA??Formula 1wherein A is a univalent aromatic group, and C* is an asymmetric carbon atom.

Piperidine derivatives, their preparation and their application in therapeutics

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, (2008/06/13)

The invention provides a compound which is a piperidine derivative of formula (I) STR1 in which R 1 is hydrogen or straight or branched (C 1 -C 6) alkyl, R 2 is hydrogen or straight or branched (C 1 -C 8) alkyl, Z and Z 1 which may be the same or differen

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