606-00-8

Basic information

• Product Name: Methyl 2-amino-3,5-dibromobenzoate
• Synonyms: METHYL 3,5-DIBROMOANTHRANILATE;METHYL 2-AMINO-3,5-DIBROMOBENZOATE;3,5-DIBROMOANTHRANILIC ACID METHYL ESTER;2-AMINO-3,5-DIBROMOBENZOIC ACID METHYL ESTER;2-Amino-3,5-dibromobenzoic acid methyl ester~Methyl 3,5-dibromoanthranilate;Mehtyl 3,5-Dibromoanthranilate;2-amino-3,5-dibromo benzate ester;METHYL 3,5-DIBROMOANTHRANULATE
• CAS NO: 606-00-8
• Molecular Formula: C₈H₇Br₂NO₂
• Molecular Weight: 308.95
• EINECS: 400-990-8
• Product Categories: Organic acids;Acids & Esters;Anilines, Amides & Amines;Bromine Compounds
• Mol File: 606-00-8.mol

Chemical Properties

• Melting Point: 89-91 °C(lit.)
• Boiling Point: 317.9 °C at 760 mmHg
• Flash Point: 146.1 °C
• Appearance: /
• Density: 1.907 g/cm³
• Vapor Pressure: 0.000373mmHg at 25°C
• Refractive Index: 1.63
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.30±0.10(Predicted)
• BRN: 3257505
• CAS DataBase Reference: Methyl 2-amino-3,5-dibromobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-3,5-dibromobenzoate(606-00-8)
• EPA Substance Registry System: Methyl 2-amino-3,5-dibromobenzoate(606-00-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 606-00-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
Methyl 2-amino-3,5-dibromobenzoate is utilized as a key intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the development of new drugs with enhanced properties and therapeutic effects.
Used in Organic Material Production:
Methyl 2-amino-3,5-dibromobenzoate also serves as a building block in the creation of various organic materials, contributing to the advancement of different industries that rely on organic chemistry for their products.
Used in Medicinal Chemistry Research:
Methyl 2-amino-3,5-dibromobenzoate is employed as a research tool in medicinal chemistry, aiding scientists in understanding the interactions between chemical compounds and biological targets, which is crucial for drug discovery and development.
Used in Drug Discovery:
Due to its ability to modify enzyme and receptor activities, Methyl 2-amino-3,5-dibromobenzoate is used in drug discovery processes to identify potential therapeutic agents that can treat various diseases and conditions.

InChI:InChI=1/C8H7Br2NO2/c1-13-8(12)5-2-4(9)3-6(10)7(5)11/h2-3H,11H2,1H3

Upstream product

• 134-20-3 2-carbomethoxyaniline 
• 186581-53-3 diazomethane 
• 609-85-8 2-amino-3,5-dibromobenzoic acid 
• 77-78-1 dimethyl sulfate 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 

Downstream Products

• 16524-04-2 2‐amino‐3,5‐dibromobenzamide 
• 50739-76-9 (2-amino-3,5-dibromophenyl)methanol 
• 76928-37-5 6,8-dibromo-1H-benzo[d][1,3]oxazin-2(4H)-one 
• 439940-35-9 3,5-bis-[2-(4-tert-butyl-phenyl)-vinyl]-benzoic acid methyl ester 
• 439940-38-2 1,3-Bis-[(E)-2-(4-tert-butyl-phenyl)-vinyl]-5-vinyl-benzene 
• 439940-36-0 {3,5-bis-[2-(4-tert-butyl-phenyl)-vinyl]-phenyl}-methanol 
• 439940-37-1 3,5-bis-[2-(4-tert-butyl-phenyl)-vinyl]-benzaldehyde 
• 51329-15-8 methyl 3,5-dibromobenzoate 
• 708271-50-5 3,5-dibromo-2-methylamino-benzaldehyde 
• 1049106-45-7 3,5-dibromo-2-methylamino-benzoic acid methyl ester 

Relevant articles and documents

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Design, synthesis and optical response of pyridine-cored V-shaped stilbenoid dendrimers

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Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists

A 5,7-dichloro-3-phenyl-3-methyl-quinoline-2,4-dione (11a) has been identified in a random screen as a lead for 5-HT6 antagonist. During the lead optimization process, several analogs were synthesized and their biological activities were investigated. Within this series, several compounds display high binding affinity and selectivity for the 5-HT6 receptor. In particular, 3-(4-hydroxyphenyl)-3-methyl-quinoline-2,4-dione (12f) exhibits high affinity (Ki = 12.3 nM) for 5-HT6 receptor with good selectivity over other serotonin and dopamine (D1-D4) receptor subtypes. In a functional adenylyl cyclase stimulation assay, this compound exhibited considerable antagonistic activity (IC50 = 0.61 μM).

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The selective monobromination of various deactivated anilines using potassium bromide and sodium perborate as oxidant has been achieved. The use of ammonium molybdate as catalyst accelerates the rate of reaction but is not essential to obtain good yields and high selectivities. (C) 2000 Elsevier Science Ltd.

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